PERFORM Publications

Keyword search (4,164 papers available)

Title		Authors	PubMed ID
1	Perceived Partner Responsiveness is Associated with Longitudinal Changes in Circulating Inflammatory Biomarkers Among Caregiving Mothers in Midlife	Gouin JP; Sánchez-Carro Y; Cruz IP; MacNeil S;	41876038 PSYCHOLOGY
2	Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact	Seixas-Lima B; Rosa-Neto P; Phillips NA; Borrie M; Roncero CT; Lahiri D; Dori D; Eintracht S; Chertkow H;	41358624 PSYCHOLOGY
3	The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss	Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;	40831565 SOH
4	Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?	Turner L; Wanasinghe AI; Brunori P; Santosa S;	40533358 SOH
5	Sex Differences in the Association Between Subjective Social Status and Imaging Markers of Cardiac Inflammation and Fibrosis	Sánchez-Carro Y; Moukarzel M; Friedrich MG; Gouin JP; Luu JM;	40471966 PSYCHOLOGY
6	Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats	Meyer C; Schoettner K; Amir S;	39624490 PSYCHOLOGY
7	Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus	Plissonneau C; Santosa S;	39553621 SOH
8	Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium	Bamisi O; Oluwalabani AO; Arogundade TT; Olajide OJ;	39303770 PSYCHOLOGY
9	Cancer anorexia-cachexia syndrome is characterized by more than one inflammatory pathway	Bruno Gagnon	38481033 HKAP
10	Editorial: Neuroepigenetics and biological mechanisms of stress-induced socio-cognitive changes	Daniels WMU; Ajonijebu DC; Olajide OJ;	38445046 CSBN
11	Changes in Purpose in Life and Low-Grade Chronic Inflammation Across Older Adulthood	Giannis I; Wrosch C; Herriot H; Gouin JP;	37643057 CONCORDIA
12	Efficacy of topical versus oral analgesic medication compared to a placebo in injured athletes: A systematic review with meta-analysis	Nudo S; Jimenez-Garcia JA; Dover G;	37278322 CONCORDIA
13	Immunoinflammatory processes: Overlapping mechanisms between obesity and eating disorders?	Breton E; Fotso Soh J; Booij L;	35594735 PSYCHOLOGY
14	Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates	Cossette C; Chourey S; Ye Q; Reddy CN; Wang R; Poulet S; Slobodchikova I; Vuckovic D; Rokach J; Powell WS;	35158054 PERFORM
15	Altered immunometabolism in adipose tissue: a major contributor to the ageing process?	Delaney KZ; Gillespie ZE; Murphy J; Wang C;	34159597 PERFORM
16	Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids	Turner L; Santosa S;	33979430 PERFORM
17	Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease.	Olajide OJ, Suvanto ME, Chapman CA	33495355 PSYCHOLOGY
18	A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue.	Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S	32926866 PERFORM
19	Inhibitory potentials of Cymbopogon citratus oil against aluminium-induced behavioral deficits and neuropathology in rats.	Temitayo GI, Olawande B, Emmanuel YO, Timothy AT, Kehinde O, Susan LF, Ezra L, Joseph OO	32839358 PSYCHOLOGY
20	In Vivo Solid-Phase Microextraction for Sampling of Oxylipins in Brain of Awake, Moving Rats	Napylov A; Reyes-Garces N; Gomez-Rios G; Olkowicz M; Lendor S; Monnin C; Bojko B; Hamani C; Pawliszyn J; Vuckovic D;	31697450 CHEMBIOCHEM
21	Interpersonal capitalization moderates the associations of chronic caregiving stress and depression with inflammation.	Gouin JP, Wrosch C, McGrath J, Booij L	31744782 PSYCHOLOGY
22	Attachment style and changes in systemic inflammation following migration to a new country among international students.	Gouin JP, MacNeil S	30406717 PERFORM
23	In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.	Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS	28476332 PERFORM
24	From neutrophils to macrophages: differences in regional adipose tissue depots.	Dam V, Sikder T, Santosa S	26667065 PERFORM
25	Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII-independent manner.	Stopnicki B, Blain M, Cui QL, Kennedy TE, Antel JP, Healy LM, Darlington PJ	30444064 PERFORM

Title:	In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.
Authors:	Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28476332?dopt=Abstract
DOI:	10.1016/j.bcp.2017.04.031
Publication:	Biochemical pharmacology
Keywords:	5-Lipoxygenase products; 5-chloro-1-methyl-1H-indole-2-carbaldehyde (PubChem CID: 23004695); 5-oxo-ETE (PubChem CID: 5283159); 5S-HETE (PubChem CID: 5280733); BDMAEE (PubChem CID: 18204); BINOL (PubChem CID: 11762); Chiral analysis; Drug metabolism; Eicosanoids; Granulocytes; Inflammation; TBDMSCl (PubChem CID: 28928); indo-1 AM (PubChem CID: 123918); methyl 5-chloro-3-methyl-5-oxopentanoate (PubChem CID: 10888500); pentyl magnesium bromide (PubChem CID: 121513990); tBuOMe (PubChem CID: 15413);
PMID:	28476332	Category:	Biochem Pharmacol	Date Added:	2019-05-31
Dept Affiliation:	PERFORM 1 Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901-6982, USA. 2 Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1, Canada. 3 Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA. 4 Department of Chemistry and Biochemistry and PERFORM Centre, Concordia University, 7141 Sherbrooke St. W., Montréal, QC H4B 1R6, Canada. 5 Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre, 1001 Decarie Blvd, Montreal, QC H4A 3J1, Canada. Electronic address: william.powell@mcgill.ca.

Description:

In vivo a-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.

Biochem Pharmacol. 2017 08 15;138:107-118

Authors: Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS

Abstract

We have developed a selective indole antagonist (230) targeting the OXE receptor for the potent eosinophil chemoattractant 5-oxo-ETE (5-oxo-6,8,11,14-eicosatetraenoic acid), that may be useful for the treatment of eosinophilic diseases such as asthma. In previous studies we identified ?2-oxidation of the hexyl side chain of racemic 230 as a major metabolic route in monkeys, but also obtained evidence for another pathway that appeared to involve hydroxylation of the hexyl side chain close to the indole. The present study was designed to investigate the metabolism of the active S-enantiomer of 230 (S230) and to identify the novel hydroxy metabolite and its chirality. Following oral administration, S230 rapidly appeared in the blood along with metabolites formed by a novel and highly stereospecific a-hydroxylation pathway, resulting in the formation of aS-hydroxy-S230. The chirality of a-hydroxy-S230 was determined by the total synthesis of the relevant diastereomers. Of the four possible diastereomers of a-hydroxy-230 only aS-hydroxy-S230 has significant OXE receptor antagonist activity and only this diastereomer was found in significant amounts in blood following oral administration of S230. Other novel metabolites of S230 identified in plasma by LC-MS/MS were aS,?2-dihydroxy-S230 and glucuronides of S230 and ?2-hydroxy-S230. Thus the alkyl side chain of S230, which is essential for its antagonist activity, is also the major target of the metabolic enzymes that terminate its antagonist activity. Modification of this side chain might result in the development of related antagonists with improved metabolic stability and efficacy.

PMID: 28476332 [PubMed - indexed for MEDLINE]

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