BookR: School of Health Core Facilities Booking
PubMed Publications| Keyword search (4,163 papers available) |  |
"In vitro" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Elucidating the toxicity of methyl parathion, imazapic, isoxaflutole, and chlorantraniliprole on human hepatocarcinoma cells and bioinspired membranes | Dos Santos DM; Rubira RJG; Salzedas GP; Kobal MB; Moreira LG; Toledo KA; Aoki PHB; DeWolf C; Camacho SA; | 40020292 CONCORDIA |
| 2 | An Anatomically Shaped Mitral Valve for Hemodynamic Testing | Darwish A; Papolla C; Rieu R; Kadem L; | 38228812 ENCS |
| 3 | Impact of Mitral Regurgitation on the Flow in a Model of a Left Ventricle. | Papolla C, Darwish A, Kadem L, Rieu R | 33000444 ENCS |
| 4 | New recombinant fibrolytic enzymes for improved in vitro ruminal fiber degradability of barley straw. | Ribeiro GO, Badhan A, Huang J, Beauchemin KA, Yang W, Wang Y, Tsang A, McAllister TA | 30053012 CSFG |
| Title: | An Anatomically Shaped Mitral Valve for Hemodynamic Testing | ||||
| Authors: | Darwish A, Papolla C, Rieu R, Kadem L | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/38228812/ | ||||
| DOI: | 10.1007/s13239-024-00714-5 | ||||
| Publication: | Cardiovascular engineering and technology | ||||
| Keywords: | In vitro; Left atrium; Left ventricle; Mitral regurgitation; Mitral valve; Mitral valve prolapse; circulatory loop; | ||||
| PMID: | 38228812 | Category: | Date Added: | 2024-01-17 | |
| Dept Affiliation: |
ENCS
1 Laboratory of Cardiovascular Fluid Dynamics, Concordia University, Montreal, QC, H3G 1M8, Canada. lcfd@encs.concordia.ca. 2 Mechanical Power Engineering Department, Assiut University, Assiut, 71515, Egypt. lcfd@encs.concordia.ca. 3 Laboratory of Cardiovascular Fluid Dynamics, Concordia University, Montreal, QC, H3G 1M8, Canada. 4 Aix-Marseille University, LBA UMR T24, Marseille, France. |
||||
Description: |
In vitro modeling of the left heart relies on accurately replicating the physiological conditions of the native heart. The targeted physiological conditions include the complex fluid dynamics coming along with the opening and closing of the aortic and mitral valves. As the mitral valve possess a highly sophisticated apparatus, thence, accurately modeling it remained a missing piece in the perfect heart duplicator puzzle. In this study, we explore using a hydrogel-based mitral valve that offers a full representation of the mitral valve apparatus. The valve is tested using a custom-made mock circulatory loop to replicate the left heart. The flow analysis includes performing particle image velocimetry measurements in both left atrium and ventricle. The results showed the ability of the new mitral valve to replicate the real interventricular and atrial flow patterns during the whole cardiac cycle. Moreover, the investigated valve has a ventricular vortex formation time of 5.2, while the peak e- and a-wave ventricular velocities was 0.9 m/s and 0.4 m/s respectively. |
