PERFORM Publications

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Title		Authors	PubMed ID
1	Functional analysis of the protocatechuate branch of the β-ketoadipate pathway in Aspergillus niger	Sgro M; Chow N; Olyaei F; Arentshorst M; Geoffrion N; Ram AFJ; Powlowski J; Tsang A;	37399977 BIOLOGY
2	TRAPPC11-related muscular dystrophy with hypoglycosylation of alpha-dystroglycan in skeletal muscle and brain	Munot P; McCrea N; Torelli S; Manzur A; Sewry C; Chambers D; Feng L; Ala P; Zaharieva I; Ragge N; Roper H; Marton T; Cox P; Milev MP; Liang WC; Maruyama S; Nishino I; Sacher M; Phadke R; Muntoni F;	34648194 BIOLOGY
3	Chronic Neuroleptic-Induced Parkinsonism Examined with Positron Emission Tomography.	Galoppin M, Berroir P, Soucy JP, Suzuki Y, Lavigne GJ, Gagnon JF, Montplaisir JY, Stip E, Blanchet PJ	32353194 PERFORM
4	The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.	Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG	32087523 PSYCHOLOGY
5	Angiotensin-I-Converting Enzyme Inhibitory Activity of Coumarins from Angelica decursiva.	Ali MY, Seong SH, Jung HA, Choi JS	31683604 CHEMBIOCHEM
6	Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.	Sparks DW, Chapman CA	27146979 PSYCHOLOGY
7	Mining Enzyme Diversity of Transcriptome Libraries through DNA Synthesis for Benzylisoquinoline Alkaloid Pathway Optimization in Yeast.	Narcross L, Bourgeois L, Fossati E, Burton E, Martin VJ	27442619 BIOLOGY

Title:	The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.
Authors:	Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32087523?dopt=Abstract
DOI:	10.1016/j.psyneuen.2020.104606
Publication:	Psychoneuroendocrinology
Keywords:	Dihydrotestosterone; Estradiol; Preclinical; Rat; Sexual desire; Solicitation;
PMID:	32087523	Category:	Psychoneuroendocrinology	Date Added:	2020-02-23
Dept Affiliation:	PSYCHOLOGY 1 Andrology, Women's Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada. 2 Psychiatry Unit, Department of Health Sciences. University of Florence, Italy; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.). Human Physiology Section "Giuseppe Pagano", Corso Tukory 129, Palermo 90134, Italy. 3 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada; Centro De Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, VER 91193, Mexico. 4 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada. 5 Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.). Human Physiology Section "Giuseppe Pagano", Corso Tukory 129, Palermo 90134, Italy. 6 Psychiatry Unit, Department of Health Sciences. University of Florence, Italy. 7 Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; I.N.B.B., Biostructures and Biosystems National Institute, Viale Delle Medaglie d'Oro 305, Rome 00136, Italy. 8 Andrology, Women's Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; I.N.B.B., Biostructures and Biosystems National Institute, Viale Delle Medaglie d'Oro 305, Rome 00136, Italy. Electronic address: linda.vignozzi@unifi.it.

Description:

The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.

Psychoneuroendocrinology. 2020 Feb 07;115:104606

Authors: Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Abstract

It is still unclear whether Testosterone (T) increases sexual desire through a stimulation of the androgen receptor in relevant brain regions or through its conversion to estrogens. The aim of this study was to clarify the mechanisms of T facilitation of female sexual desire by assessing the effect of a non-aromatizable androgen (Dihydrotestosterone, DHT) in a validated animal model. Ovariectomized (OVX) Long-Evans rats were treated with oil (O) + O, 10 mcg Estradiol Benzoate (EB) + O, 10 mcg EB?+?500 mcg Progesterone (P), O?+?500 mcg DHT or 10 mcg EB?+?500 mcg DHT (n?=?12 per group). EB was administered 48?h, while P and DHT 4?h, prior to 4 sexual behavioral testing sessions in bisected unilevel pacing chambers. Appetitive behaviors (the frequencies of hops/darts and solicitations) were considered as the main outcome measure. Sexual receptivity indexes [lordosis magnitude, expressed as lordosis rating (LR), and lordosis quotient (LQ)], rejection responses, as well as mounts, intromissions and ejaculations received from the male were also coded. The probability of transition among sexual behaviors was evaluated by Transition Matrices; T-Pattern analysis was performed to detect hidden repeated temporal behavioral sequences. Preliminary analyses found no statistically significant differences between the O?+?O and EB?+?O groups, therefore we excluded the EB?+?O group from further analyses. Rats treated with EB?+?DHT displayed significantly more appetitive behaviors compared to negative controls (O?+?O and O?+?DHT), whereas no difference was observed between EB?+?DHT rats and positive controls (EB?+?P); noteworthy, a higher number of appetitive behaviors was observed in the O?+?DHT group compared to the O?+?O group. Furthermore, rats treated with EB?+?DHT showed significantly higher receptivity measures (LR and LQ) and received more mounts, intromissions and ejaculations compared to negative controls (O?+?O and O?+?DHT), to levels equivalent to EB?+?P. No differences were detected in female-male mounts or rejection responses among the 4 groups. Under a qualitative perspective, full solicitation was found exclusively in T-patterns of the EB?+?DHT group, which was also the only one to display T-patterns of higher order encompassing appetitive behaviors-only events. In conclusion, the administration of DHT in EB-primed OVX Long-Evans rats enhances sexual behavior measures. Specifically, DHT seems to stimulate sequences of appetitive behaviors separated from copulative/reproductive measures. Our data support an independent role of androgens in the facilitation of female sexual desire.

PMID: 32087523 [PubMed - as supplied by publisher]

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