Keyword search (4,163 papers available)

"Functional magnetic resonance imaging" Keyword-tagged Publications:

Title Authors PubMed ID
1 Sleep neuroimaging: Review and future directions Pereira M; Chen X; Paltarzhytskaya A; Pache?o Y; Muller N; Bovy L; Lei X; Chen W; Ren H; Song C; Lewis LD; Dang-Vu TT; Czisch M; Picchioni D; Duyn J; Peigneux P; Tagliazucchi E; Dresler M; 39940102
HKAP
2 Neural correlates of impulsivity in amphetamine use disorder Kaboodvand N; Shabanpour M; Guterstam J; 38991286
ENCS
3 Neurophysiology, Neuropsychology, and Epilepsy, in 2022: Hills We Have Climbed and Hills Ahead. Neurophysiology in epilepsy Frauscher B; Bénar CG; Engel JJ; Grova C; Jacobs J; Kahane P; Wiebe S; Zjilmans M; Dubeau F; 37119580
PERFORM
4 Bilingual language experience and the neural underpinnings of working memory Kousaie S; Chen JK; Baum SR; Phillips NA; Titone D; Klein D; 34728242
PSYCHOLOGY
5 Evaluation of a personalized functional near infra-red optical tomography workflow using maximum entropy on the mean Cai Z; Uji M; Aydin Ü; Pellegrino G; Spilkin A; Delaire É; Abdallah C; Lina JM; Grova C; 34342073
PERFORM
6 Modulation of premotor cortex response to sequence motor learning during escitalopram intake. Molloy EN; Mueller K; Beinhölzl N; Blöchl M; Piecha FA; Pampel A; Steele CJ; Scharrer U; Zheleva G; Regenthal R; Sehm B; Nikulin VV; Möller HE; Villringer A; Sacher J; 33148103
PSYCHOLOGY
7 Language learning experience and mastering the challenges of perceiving speech in noise Kousaie S; Baum S; Phillips NA; Gracco V; Titone D; Chen JK; Chai XJ; Klein D; 31284145
PSYCHOLOGY
8 Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity. Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L 28774705
PSYCHOLOGY

 

Title:Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.
Authors:Ismaylova EDi Sante JSzyf MNemoda ZYu WJPomares FBTurecki GGobbi GVitaro FTremblay REBooij L
Link:https://www.ncbi.nlm.nih.gov/pubmed/28774705?dopt=Abstract
DOI:10.1016/j.euroneuro.2017.07.005
Publication:European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Keywords:DNA methylationFrontal cortexFunctional magnetic resonance imagingResilienceSerotonin transporter
PMID:28774705 Category:Eur Neuropsychopharmacol Date Added:2019-06-20
Dept Affiliation: PSYCHOLOGY
1 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada.
2 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
3 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
4 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada.
5 Douglas Mental Health University Institute, Verdun, Canada; Department of Psychiatry, McGill University, Montreal, Canada.
6 Department of Psychiatry, McGill University, Montreal, Canada.
7 CHU Sainte-Justine Research Centre, Montreal, Canada; School of Psychoeducation, University of Montreal, Montreal, Canada.
8 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology and Pediatrics, University of Montreal, Montreal, Canada; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland.
9 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada; Department of Psychiatry, McGill University, Montreal, Canada. Electronic address: linda.booij@concordia.ca.

Description:

Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.

Eur Neuropsychopharmacol. 2017 10;27(10):1032-1041

Authors: Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L

Abstract

Early adversity can influence gene expression via epigenetic mechanisms, including DNA methylation. Peripheral tissues are essential in psychiatric epigenetics, as methylation generally cannot be assessed in the living human brain. Several magnetic resonance imaging (MRI) studies show associations of peripheral serotonin transporter gene (SLC6A4) methylation with function and/or structure of frontal-limbic circuits and brain's resting-state. Commonly used samples are derived from blood, saliva or buccal cells. However, little is known regarding which peripheral tissue is most strongly associated with human brain processes. The aim of the current study was to compare the extent of the association between peripheral SLC6A4 promoter methylation and frontal-limbic function, structure and resting-state in healthy individuals across peripheral tissues. Forty healthy prospectively-followed adults underwent anatomical, resting-state and functional MRI. Saliva-, blood- and buccal-derived DNA methylation was assessed by pyrosequencing. Blood-derived SLC6A4 methylation was positively associated with superior frontal gray matter (GM) volume and with right lateral parietal area (RLP)-frontal pole regional resting-state functional connectivity (rsFC). Saliva-derived SLC6A4 methylation was positively associated with superior frontal GM volume. Buccal-derived SLC6A4 methylation was positively associated with superior and inferior frontal and anterior cingulate cortical (ACC) GM volumes, and with RLP-ACC, frontal pole and medial prefrontal regional rsFC. Current results confirmed the relevance of peripheral methylation for frontal-limbic processes in humans. Buccal cells may be the most sensitive cell type when studying SLC6A4 promoter methylation and its associated risk for neural vulnerability and resilience for psychopathologies in which serotonin is implicated. These data should be further validated in clinical populations.

PMID: 28774705 [PubMed - indexed for MEDLINE]





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