PERFORM Publications

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Title		Authors	PubMed ID
1	Progesterone and allopregnanolone facilitate excitatory synaptic transmission in the infralimbic cortex via activation of membrane progesterone receptors	Rahaei N; Buynack LM; Kires L; Movasseghi Y; Chapman CA;	39722289 PSYCHOLOGY
2	Optogenetic stimulation of infralimbic cortex projections to the paraventricular thalamus attenuates context-induced renewal	Brown A; Chaudhri N;	36373226 PSYCHOLOGY
3	Calcium activity is a degraded estimate of spikes	Hart EE; Gardner MPH; Panayi MC; Kahnt T; Schoenbaum G;	36368324 PSYCHOLOGY
4	Corticostriatal suppression of appetitive Pavlovian conditioned responding	Villaruel FR; Martins M; Chaudhri N;	34880119 PSYCHOLOGY
5	Mechanisms of higher-order learning in the amygdala	Gostolupce D; Iordanova MD; Lay BPP;	34197867 PSYCHOLOGY
6	Adaptive behaviour under conflict: deconstructing extinction, reversal, and active avoidance learning.	Manning EE, Bradfield LA, Iordanova MD	33035525 CSBN
7	State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis.	Tremblay SA, Chapman CA, Courtemanche R	31736718 HKAP
8	Prefrontal Cortex and Multiparity in Lactation.	Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD	31437474 CSBN
9	17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo.	Shams WM, Sanio C, Quinlan MG, Brake WG	27256507 PSYCHOLOGY
10	Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors.	Voyer D, Lévesque D, Rompré PP	27267684 CSBN
11	Gating of the neuroendocrine stress responses by stressor salience in early lactating female rats is independent of infralimbic cortex activation and plasticity.	Hillerer KM, Woodside B, Parkinson E, Long H, Verlezza S, Walker CD	29397787 CSBN
12	Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.	Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L	28774705 PSYCHOLOGY
13	Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.	Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L	25741267 PERFORM

Title:	Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors.
Authors:	Voyer D, Lévesque D, Rompré PP
Link:	https://www.ncbi.nlm.nih.gov/pubmed/27267684?dopt=Abstract
DOI:	10.1016/j.neuropharm.2016.06.005
Publication:	Neuropharmacology
Keywords:	Accumbens; Amphetamine; ERK; Glutamate; Neurotensin; Prefrontal cortex; Ventral midbrain;
PMID:	27267684	Category:	Neuropharmacology	Date Added:	2019-06-20
Dept Affiliation:	CSBN 1 Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada. 2 Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; FRQ-S Research Group in Behavioral Neurobiology, Concordia University, Montréal, Quebec, Canada. Electronic address: pierre-paul.rompre@umontreal.ca.

Description:

Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors.

Neuropharmacology. 2017 01;112(Pt A):150-163

Authors: Voyer D, Lévesque D, Rompré PP

Abstract

Previous studies have shown that activation of ventral midbrain NMDA receptors is required to initiate sensitization by amphetamine. In view of the recent evidence that neurotensin modulates ventral midbrain glutamate neurotransmission, we tested the hypothesis that neurotensin is acting upstream to glutamate to initiate sensitization to the behavioral and neurochemical effects of amphetamine. During a first testing phase, adult male rats implanted with bilateral ventral midbrain cannulae were injected every second day for three days with D-[Tyr11]neurotensin (1.5 nmol/side), the preferred NMDA GluN2A/B antagonist, CPP (40 or 120 pmol/side), the selective GluN2B antagonist, Ro04-5595 (200 or 1200 pmol/side), CPP (40 or 120 pmol/side) + D-[Tyr11]neurotensin (1.5 nmol/side) or Ro04-5595 (200 or 1200 pmol/side) + D-[Tyr11]neurotensin (1.5 nmol/side) and locomotor activity was measured immediately after the injection. Five days after the last central injection, the locomotor response or the expression of phosphorylated extracellular signal-regulated kinases 1/2 (pERK1/2) in neurons of different limbic nuclei was measured following a systemic injection of amphetamine sulfate (0.75 mg/kg, i.p.). Results show that amphetamine induced significantly stronger locomotor activity and pERK1/2 expression in the nucleus accumbens shell and infralimbic cortex in neurotensin pre-exposed animals than in controls (vehicle pre-exposed). These sensitization effects initiated by neurotensin were prevented by CPP, but not Ro04-5595. These results support the hypothesis that neurotensin is stimulating glutamate neurotransmission to initiate neural changes that sub-serve amphetamine sensitization and that glutamate is acting on NMDA receptors that are mostly likely composed of GluN2A, but not GluN2B, subunits. This article is part of the Special Issue entitled 'Ionotropic glutamate receptors'.

PMID: 27267684 [PubMed - indexed for MEDLINE]

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