Keyword search (4,164 papers available)

"Fluconazole" Keyword-tagged Publications:

Title Authors PubMed ID
1 Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y; 38929106
BIOLOGY
2 Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections Feng Y; Lu H; Whiteway M; Jiang Y; 37918789
BIOLOGY
3 A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y; 36475771
BIOLOGY
4 Candida albicans targets that potentially synergize with fluconazole. Lu H, Shrivastava M, Whiteway M, Jiang Y 33587857
BIOLOGY

 

Title:Candida albicans targets that potentially synergize with fluconazole.
Authors:Lu HShrivastava MWhiteway MJiang Y
Link:https://www.ncbi.nlm.nih.gov/pubmed/33587857
DOI:10.1080/1040841X.2021.1884641
Publication:Critical reviews in microbiology
Keywords:Candida albicansFluconazolesynergistic targets
PMID:33587857 Category:Crit Rev Microbiol Date Added:2021-02-16
Dept Affiliation: BIOLOGY
1 Department of Pharmacology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
2 Department of Biology, Concordia University, Montreal, QC, Canada.

Description:

Candida albicans targets that potentially synergize with fluconazole.

Crit Rev Microbiol. 2021 Feb 15; :1-15

Authors: Lu H, Shrivastava M, Whiteway M, Jiang Y

Abstract

Fluconazole has characteristics that make it widely used in the clinical treatment of C. albicans infections. However, fluconazole has only a fungistatic activity in C. albicans, therefore, in the long-term treatment of C. albicans infection with fluconazole, C. albicans has the potential to acquire fluconazole resistance. A promising approach to increase fluconazole's efficacy is identifying potential targets of drugs that can enhance the antifungal effect of fluconazole, or even make the drug fungicidal. In this review, we systematically provide a global overview of potential targets of drugs synergistic with fluconazole in C. albicans, identify new avenues for research on fluconazole potentiation, and highlight the promise of combinatorial strategies with fluconazole in combatting C. albicans infections.

PMID: 33587857 [PubMed - as supplied by publisher]





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