Keyword search (4,164 papers available)

"Estrogens" Keyword-tagged Publications:

Title Authors PubMed ID
1 Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex Olajide OJ; Batallán Burrowes AA; da Silva IF; Bergdahl A; Chapman CA; 39617168
HKAP
2 The role of progesterone in memory bias during spatial navigation in females Eamonn L Gomez-Perales 36165431
PSYCHOLOGY
3 G protein-coupled estrogen receptor-1 enhances excitatory synaptic responses in the entorhinal cortex Batallán Burrowes AA; Sundarakrishnan A; Bouhour C; Chapman CA; 34399010
PSYCHOLOGY
4 Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats. Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG 28062232
PSYCHOLOGY
5 17β-estradiol locally increases phasic dopamine release in the dorsal striatum. Shams WM, Cossette MP, Shizgal P, Brake WG 29175028
CSBN

 

Title:Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.
Authors:Almey A,  Arena L,  Oliel J,  Shams WM,  Hafez N,  Mancinelli C,  Henning L,  Tsanev A,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/28062232?dopt=Abstract
DOI:10.1016/j.yhbeh.2016.12.010
Publication:Hormones and behavior
Keywords:Antipsychotic;  Estrogens;  Schizophrenia;  Set-shifting; 
PMID:28062232 Category:Horm Behav Date Added:2019-06-20
Dept Affiliation: PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: anne.almey@gmail.com.
2 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada.
3 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: waqqas19@gmail.com.
4 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: wayne.brake@concordia.ca.

Description:

Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.

Horm Behav. 2017 03;89:113-120

Authors: Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Abstract

There are sex differences associated with schizophrenia, as women exhibit later onset of the disorder, less severe symptomatology, and better response to antipsychotic medications. Estrogens are thought to play a role in these sex differences; estrogens facilitate the effects of antipsychotic medications to reduce the positive symptoms of schizophrenia, but it remains unclear whether estrogens protect against the cognitive symptoms of this disorder. Amphetamine sensitization is used to model some symptoms of schizophrenia in rats, including cognitive deficits like excessive perseveration and slower reversal learning. In this experiment female rats were administered a sensitizing regimen of amphetamine to mimic these cognitive symptoms. They were ovariectomized and administered either low or high estradiol replacement as well as chronic administration of the antipsychotic haloperidol, and were assessed in tests of perseveration and reversal learning. Results of these experiments demonstrated that, in amphetamine-sensitized rats, estradiol alone does not affect perseveration or reversal learning. However, low estradiol facilitates a 0.25mg/day dose of haloperidol to reduce perseveration and improve reversal learning. Combined high estradiol and 0.25mg/day haloperidol has no effect on perseveration or reversal learning, but high estradiol facilitates the effects of 0.13mg/day haloperidol to reduce perseveration and improve reversal learning. Thus, in amphetamine-sensitized female rats, 0.25mg/day haloperidol only improved perseveration and reversal learning when estradiol was low, while 0.13mg/day haloperidol only improved these cognitive processes when estradiol was high. These findings suggest that estradiol facilitates the effects of haloperidol to improve perseveration and reversal learning in a dose-dependent manner.

PMID: 28062232 [PubMed - indexed for MEDLINE]




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