PERFORM Publications

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Title		Authors	PubMed ID
1	Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex	Olajide OJ; Batallán Burrowes AA; da Silva IF; Bergdahl A; Chapman CA;	39617168 HKAP
2	The role of progesterone in memory bias during spatial navigation in females	Eamonn L Gomez-Perales	36165431 PSYCHOLOGY
3	Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons	Almey A; Milner TA; Brake WG;	35397175 CSBN
4	G protein-coupled estrogen receptor-1 enhances excitatory synaptic responses in the entorhinal cortex	Batallán Burrowes AA; Sundarakrishnan A; Bouhour C; Chapman CA;	34399010 PSYCHOLOGY
5	Estrogen receptor α and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum.	Almey A, Milner TA, Brake WG	27080432 PSYCHOLOGY
6	Modulation of spatial and response strategies by phase of the menstrual cycle in women tested in a virtual navigation task.	Hussain D, Hanafi S, Konishi K, Brake WG, Bohbot VD	27213559 PSYCHOLOGY
7	Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.	Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG	28062232 PSYCHOLOGY
8	17β-estradiol locally increases phasic dopamine release in the dorsal striatum.	Shams WM, Cossette MP, Shizgal P, Brake WG	29175028 CSBN
9	The Sexual Dimorphism of Lipid Kinetics in Humans.	Santosa S, Jensen MD	26191040 PERFORM

Title:	17β-estradiol locally increases phasic dopamine release in the dorsal striatum.
Authors:	Shams WM, Cossette MP, Shizgal P, Brake WG
Link:	https://www.ncbi.nlm.nih.gov/pubmed/29175028?dopt=Abstract
DOI:	10.1016/j.neulet.2017.11.039
Publication:	Neuroscience letters
Keywords:	Estrogens; Fast-scan cyclic voltammetry;
PMID:	29175028	Category:	Neurosci Lett	Date Added:	2019-06-20
Dept Affiliation:	CSBN 1 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: waqqas.shams@gmail.com. 2 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: mpy_cossette@hotmail.com. 3 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: peter.shizgal@concordia.ca. 4 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: wayne.brake@concordia.ca.

Description:

17ß-estradiol locally increases phasic dopamine release in the dorsal striatum.

Neurosci Lett. 2018 02 05;665:29-32

Authors: Shams WM, Cossette MP, Shizgal P, Brake WG

Abstract

Studies using in vivo microdialysis have shown that 17ß-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anesthetized (1.5mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum. Rats were ovariectomized and implanted with a silastic tube containing 5% E2 in cholesterol, previously shown to mimic low physiological serum concentrations of~20-25pg/mL. DA release was evoked every 1min by delivering biphasic electrical stimulation in the substantia nigra. Local infusions of E2 (244.8pg/µl) into the dorsal striatum increased the amplitude of the electrically evoked DA transients. Behaviorally significant stimuli and events trigger phasic release of DA. The present findings predict that E2 would boost such signaling in behaving subjects.

PMID: 29175028 [PubMed - indexed for MEDLINE]

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