Keyword search (4,164 papers available)

"Desire" Keyword-tagged Publications:

Title Authors PubMed ID
1 Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats. González Cautela BV; Quintana GR; Akerman J; Pfaus JG; 33242109
PSYCHOLOGY
2 The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol. Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG 32087523
PSYCHOLOGY
3 Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone. Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG 31447629
CSBN
4 Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial. Tuiten A, Michiels F, Böcker KB, Höhle D, van Honk J, de Lange RP, van Rooij K, Kessels R, Bloemers J, Gerritsen J, Janssen P, de Leede L, Meyer JJ, Everaerd W, Frijlink HW, Koppeschaar HP, Olivier B, Pfaus JG 30016917
CSBN
5 Comparing Subjective Ratings of Sexual Arousal and Desire in Partnered Sexual Activities from Women of Different Sexual Orientations Persson TJ; Ryder AG; Pfaus JG; 25808718
PSYCHOLOGY

 

Title:Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.
Authors:González Cautela BV,  Quintana GR,  Akerman J,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/33242109
DOI:10.1007/s00213-020-05728-0
Publication:Psychopharmacology
Keywords:Desire;  Orgasm;  SSRI;  Sexual side effects;  Treatment; 
PMID:33242109 Category:Psychopharmacology (Berl) Date Added:2020-11-27
Dept Affiliation: PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, Canada.
2 Escuela de Psicología y Filosofía, Universidad de Tarapacá, 1010069, Arica, Arica y Parinacota, Chile.
3 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, Canada. jpfaus@uv.mx.
4 Centro de Investigaciones Cerebrales, Universidad Veracruzana, CP 91193, Xalapa, VER, Mexico. jpfaus@uv.mx.

Description:

Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.

Psychopharmacology (Berl). 2020 Nov 26; :

Authors: González Cautela BV, Quintana GR, Akerman J, Pfaus JG

Abstract

RATIONALE: Sexual side effects of chronic treatment with selective serotonin reuptake inhibitors (SSRIs) in humans include anorgasmia and loss of sexual desire and/or arousal which interferes with treatment compliance. There are few options at present to reduce these effects. Because orgasm and desire are mediated in part by activation of sympathetic arousal, we asked whether the sympathomimetic effects of acute caffeine treatment could reverse these effects.

OBJECTIVE: The present study examined whether acute treatment with caffeine (CAF; 10 or 20 mg/kg, ip) versus vehicle could ameliorate the disruption of appetitive and consummatory measures of copulatory behavior produced by chronic fluoxetine (10 mg/kg, sc) in adult, sexually active female or male rats.

METHODS: Sexually experienced female or male rats received daily injections of FLU over a 24-day period and were tested for sexual behaviors five times at 4-day intervals during this period in bilevel pacing chambers. Females had been ovariectomized and given hormone replacement with estradiol benzoate and progesterone prior to each test. Males were left gonadally intact. Four days after the final FLU test, rats were randomly assigned to one of the three doses of CAF and received ip injections of CAF or the saline vehicle 60 min before testing.

RESULTS: Chronic FLU reduced solicitations and lordosis over time in females and reduced the number of ejaculations in males. Both doses of CAF restored solicitations and lordosis in females and ejaculations in males. On their own, both doses of CAF increased females' pacing behavior and the number of mounts and intromissions in the males.

CONCLUSIONS: Stimulation of sympathetic outflow by CAF may constitute a readily accessible on-demand treatment for the sexual side-effects of SSRIs.

PMID: 33242109 [PubMed - as supplied by publisher]




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