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PubMed Publications| Keyword search (4,163 papers available) |  |
"Coronavirus" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Upcycling face mask wastes generated during COVID-19 into value-added engineering materials: A review | Sina Pourebrahimi | 36055514 ENCS |
| 2 | Predicted coronavirus Nsp5 protease cleavage sites in the human proteome | Scott BM; Lacasse V; Blom DG; Tonner PD; Blom NS; | 35379171 ENCS |
| 3 | Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection | Safiabadi Tali SH; LeBlanc JJ; Sadiq Z; Oyewunmi OD; Camargo C; Nikpour B; Armanfard N; Sagan SM; Jahanshahi-Anbuhi S; | 33980687 IMAGING |
| 4 | The contribution of dry indoor built environment on the spread of Coronavirus: Data from various Indian states. | V AAR, R V, Haghighat F | 32834934 ENCS |
| 5 | Protocol for a partially nested randomised controlled trial to evaluate the effectiveness of the scleroderma patient-centered intervention network COVID-19 home-isolation activities together (SPIN-CHAT) program to reduce anxiety among at-risk scleroderma patients. | Thombs BD, Kwakkenbos L, Carrier ME, Bourgeault A, Tao L, Harb S, Gagarine M, Rice D, Bustamante L, Ellis K, Duchek D, Wu Y, Bhandari PM, Neupane D, Carboni-Jiménez A, Henry RS, Krishnan A, Sun Y, Levis B, He C, Turner KA, Benedetti A, Culos-Reed N, El-Baalbaki G, Hebblethwaite S, Bartlett SJ, Dyas L, Patten S, Varga J, Scleroderma Patient-centered Intervention Network (SPIN) COVID-19 Patient Advisory Team, SPIN Investigators | 32521358 PSYCHOLOGY |
| 6 | Protocol for a partially nested randomised controlled trial to evaluate the effectiveness of the scleroderma patient-centered intervention network COVID-19 home-isolation activities together (SPIN-CHAT) program to reduce anxiety among at-risk scleroderma patients. | Fortuné C, Gietzen A, Guillot G, Lewis N, Nielsen K, Richard M, Sauvé M, Welling J, SPIN Investigators, Baron M, Furst DE, Gottesman K, Malcarne V, Mayes MD, Mouthon L, Nielson WR, Riggs R, Wigley F, Assassi S, Boutron I, Ells C, van den Ende C, Fligelstone K, Frech T, Godard D, Harel D, Hinchcliff M, Hudson M, Johnson SR, Larche M, Leite C, Nguyen C, Pope J, Portales A, Rannou F, Reyna TSR, Schouffoer AA, Suarez-Almazor ME, Agard C, Albert A, André M, Arsenault G, Benzidia I, Bernstein EJ, Berthier S, Biss | 32419703 PSYCHOLOGY |
| Title: | Predicted coronavirus Nsp5 protease cleavage sites in the human proteome | ||||
| Authors: | Scott BM, Lacasse V, Blom DG, Tonner PD, Blom NS | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35379171/ | ||||
| DOI: | 10.1186/s12863-022-01044-y | ||||
| Publication: | BMC genomic data | ||||
| Keywords: | 3CLpro; COVID-19; Coronavirus; Human proteins; Human proteome; Mpro; Nsp5; Protease; SARS-CoV-2; | ||||
| PMID: | 35379171 | Category: | Date Added: | 2022-04-05 | |
| Dept Affiliation: |
ENCS
1 Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD, USA. ben_scott@outlook.com. 2 Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA. ben_scott@outlook.com. 3 Centre for Applied Synthetic Biology, Concordia University, Montreal, Quebec, Canada. ben_scott@outlook.com. 4 Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. 5 Department of Applied Mathematics and Computer Science, Technical University of Denmark, Lyngby, Denmark. 6 Statistical Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD, USA. 7 Department of Bioengineering, Technical University of Denmark, Kongens Lyngby, Denmark. |
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Description: |
Background: The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several coronaviruses have also been found to cleave host proteins, disrupting molecular pathways involved in innate immunity. Nsp5 from the recently emerged SARS-CoV-2 virus interacts with and can cleave human proteins, which may be relevant to the pathogenesis of COVID-19. Based on the continuing global pandemic, and emerging understanding of coronavirus Nsp5-human protein interactions, we set out to predict what human proteins are cleaved by the coronavirus Nsp5 protease using a bioinformatics approach. Results: Using a previously developed neural network trained on coronavirus Nsp5 cleavage sites (NetCorona), we made predictions of Nsp5 cleavage sites in all human proteins. Structures of human proteins in the Protein Data Bank containing a predicted Nsp5 cleavage site were then examined, generating a list of 92 human proteins with a highly predicted and accessible cleavage site. Of those, 48 are expected to be found in the same cellular compartment as Nsp5. Analysis of this targeted list of proteins revealed molecular pathways susceptible to Nsp5 cleavage and therefore relevant to coronavirus infection, including pathways involved in mRNA processing, cytokine response, cytoskeleton organization, and apoptosis. Conclusions: This study combines predictions of Nsp5 cleavage sites in human proteins with protein structure information and protein network analysis. We predicted cleavage sites in proteins recently shown to be cleaved in vitro by SARS-CoV-2 Nsp5, and we discuss how other potentially cleaved proteins may be relevant to coronavirus mediated immune dysregulation. The data presented here will assist in the design of more targeted experiments, to determine the role of coronavirus Nsp5 cleavage of host proteins, which is relevant to understanding the molecular pathology of coronavirus infection. |
