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PubMed Publications| Keyword search (4,164 papers available) |  |
"Cognitive behavioral therapy for insomni" Keyword-tagged Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Efficacy of cognitive behavioral therapy for insomnia and lemborexant medication for different subtypes of chronic insomnia: study protocol for a randomized controlled trial | Chen SJ; Ivers H; Dang-Vu TT; Shapiro CM; Carney CE; Robillard R; Morin CM; | 40346496 HKAP |
| Title: | Efficacy of cognitive behavioral therapy for insomnia and lemborexant medication for different subtypes of chronic insomnia: study protocol for a randomized controlled trial | ||||
| Authors: | Chen SJ, Ivers H, Dang-Vu TT, Shapiro CM, Carney CE, Robillard R, Morin CM | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40346496/ | ||||
| DOI: | 10.1186/s12888-025-06878-1 | ||||
| Publication: | BMC psychiatry | ||||
| Keywords: | Cognitive behavioral therapy for insomnia; Insomnia phenotypes; Pharmacotherapy; Treatment; | ||||
| PMID: | 40346496 | Category: | Date Added: | 2025-05-10 | |
| Dept Affiliation: |
HKAP
1 École de Psychologie, Université Laval, 2325 Rue Des Bibliothèques, Québec, Québec, G1V 0A6, Canada. 2 Centre de recherche CERVO/Brain Research Center, 2301 Av. D'Estimauville, Québec, Québec, G1E 1T2, Canada. 3 Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. 4 Department of Health, Kinesiology and Applied Physiology, Concordia University, 7141 Sherbrooke Street West, Montréal, Québec, H4B 1R6, Canada. 5 Centre de Recherche de L'Institut Universitaire de Gériatrie de Montréal (CRIUGM), CIUSSS du Centre-Sud-de-L'île-de-Montréal, 4565 Queen Mary Road, Montréal, Québec, H3W 1W5, Canada. 6 Medical Sciences, University of Toronto, 399 Bathurst St, MP7, 421, Toronto, Ontario, M5T 2S8, Canada. 7 Department of Psychology, Toronto Metropolitan University, 350 Victoria Street, Toronto, Ontario, M5B 2K3, Canada. 8 School of Psychology, University of Ottawa, 136 J |
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Description: |
Introduction: Insomnia is a prevalent yet under-characterized disorder, particularly regarding the heterogeneity of patients and their associated responses to different treatment modalities. This often leads to suboptimal management. There is a need to consider personalized approaches tailored to the characteristics of insomnia phenotypes with regard to objective evidence of shortened sleep duration (< 6 h). This study will examine whether there is a differential treatment response to cognitive behavioral therapy for insomnia (CBT-I) versus pharmacotherapy (lemborexant) as a function of insomnia phenotypes (i.e., ± 6 h of sleep). Methods: This study is a three-arm pragmatic randomized clinical trial, which will enroll 90 adults with chronic insomnia disorder and anxiety/depressive symptoms. Eligible participants will be randomized to one of three conditions (1:1:1) involving CBT-I, lemborexant (Dual Orexin Receptor Antagonist) or placebo medication. Treatment outcomes will be assessed at post-treatment and 6-month follow-up. Insomnia symptom severity as measured by the Insomnia Severity Index will serve as the primary outcome for treatment comparisons. Secondary outcomes will include daily sleep/wake variables derived from the Consensus Sleep Diary, subjective measures of fatigue, mood, mental well-being, functional impairments, and sleep-related beliefs and attitudes. In addition, changes in cognitive performance will be examined as an exploratory outcome. Sleep reactivity and arousal level will be evaluated as potential mediators of treatment-related changes in CBT-I and pharmacotherapy. Discussion: This study will contribute to the development of personalized medicine for managing different insomnia phenotypes and will have implication for knowledge mobilization of sleep research. Trial registration: ClinicalTrials.gov. Identifier: NCT06779149. Registered on 12 January 2025. |
