PERFORM Publications

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Title		Authors	PubMed ID
1	Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans	Zhen C; Wang L; Feng Y; Whiteway M; Hang S; Yu J; Lu H; Jiang Y;	38995235 BIOLOGY
2	Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species	Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y;	38929106 BIOLOGY
3	Antimicrobial photodynamic therapy against a dual-species cariogenic biofilm using a ruthenium-loaded resin-based dental material	Leite ML; Comeau P; Aghakeshmiri S; Lange D; Rodrigues LKA; Branda N; Manso AP;	38395246 ENCS
4	A Systematic Evaluation of Curcumin Concentrations and Blue Light Parameters towards Antimicrobial Photodynamic Therapy against Cariogenic Microorganisms	Comeau P; Manso A;	38140048 ENCS
5	Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections	Feng Y; Lu H; Whiteway M; Jiang Y;	37918789 BIOLOGY
6	Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds	Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT;	37888959 BIOLOGY
7	The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans	Shrivastava M; Kouyoumdjian GS; Kirbizakis E; Ruiz D; Henry M; Vincent AT; Sellam A; Whiteway M;	37791798 BIOLOGY
8	Genome sequencing of 15 acid-tolerant yeasts	Bagley JA; Pyne ME; Exley K; Kevvai K; Wang Q; Whiteway M; Martin VJJ;	37747226 BIOLOGY
9	A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols	Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y;	36475771 BIOLOGY
10	A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies	Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT;	35972285 BIOLOGY
11	Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate	Feng Y; Zhang Y; Li J; Omran RP; Whiteway M; Feng J;	35886903 BIOLOGY
12	Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions	Godoy P; Darlington PJ; Whiteway M;	35450285 PERFORM
13	SAGA Complex Subunits in Candida albicans Differentially Regulate Filamentation, Invasiveness, and Biofilm Formation	Rashid S; Correia-Mesquita TO; Godoy P; Omran RP; Whiteway M;	35350439 BIOLOGY
14	The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans	Omran RP; Ramírez-Zavala B; Aji Tebung W; Yao S; Feng J; Law C; Dumeaux V; Morschhäuser J; Whiteway M;	34849863 PERFORM
15	Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target	Li W; Shrivastava M; Lu H; Jiang Y;	33989979 BIOLOGY
16	Signal-mediated localization of Candida albicans pheromone response pathway components	Costa ACBP; Omran RP; Law C; Dumeaux V; Whiteway M;	33793759 PERFORM
17	Candida albicans targets that potentially synergize with fluconazole.	Lu H, Shrivastava M, Whiteway M, Jiang Y	33587857 BIOLOGY
18	Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans.	Yao S, Feng Y, Islam A, Shrivastava M, Gu H, Lu Y, Sheng J, Whiteway M, Feng J	33363697 BIOLOGY
19	Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans.	Feng J, Yao S, Dong Y, Hu J, Whiteway M, Feng J	32075883 BIOLOGY
20	RNA sequencing reveals an additional Crz1-binding motif in promoters of its target genes in the human fungal pathogen Candida albicans.	Xu H, Fang T, Omran RP, Whiteway M, Jiang L	31900175 BIOLOGY
21	Start-up of oxygen-limited autotrophic partial nitrification-anammox process for treatment of nitrite-free wastewater in a single-stage hybrid bioreactor.	Hosseinpour B, Saborimanesh N, Yerushalmi L, Walsh D, Mulligan CN	31378146 CSFG
22	The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans.	Tebbji F, Chen Y, Sellam A, Whiteway M	29152582 BIOLOGY
23	Chemogenomic Profiling of the Fungal Pathogen Candida albicans.	Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M	29203491 BIOLOGY
24	MAP Kinase Regulation of the Candida albicans Pheromone Pathway.	Rastghalam G, Omran RP, Alizadeh M, Fulton D, Mallick J, Whiteway M	30787119 BIOLOGY
25	The evolutionary rewiring of the ribosomal protein transcription pathway modifies the interaction of transcription factor heteromer Ifh1-Fhl1 (interacts with forkhead 1-forkhead-like 1) with the DNA-binding specificity element.	Mallick J, Whiteway M	23625919 BIOLOGY
26	Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response.	Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M	30530734 PERFORM

Title:	Candida albicans targets that potentially synergize with fluconazole.
Authors:	Lu H, Shrivastava M, Whiteway M, Jiang Y
Link:	https://www.ncbi.nlm.nih.gov/pubmed/33587857
DOI:	10.1080/1040841X.2021.1884641
Publication:	Critical reviews in microbiology
Keywords:	Candida albicans; Fluconazole; synergistic targets;
PMID:	33587857	Category:	Crit Rev Microbiol	Date Added:	2021-02-16
Dept Affiliation:	BIOLOGY 1 Department of Pharmacology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Biology, Concordia University, Montreal, QC, Canada.

Description:

Candida albicans targets that potentially synergize with fluconazole.

Crit Rev Microbiol. 2021 Feb 15; :1-15

Authors: Lu H, Shrivastava M, Whiteway M, Jiang Y

Abstract

Fluconazole has characteristics that make it widely used in the clinical treatment of C. albicans infections. However, fluconazole has only a fungistatic activity in C. albicans, therefore, in the long-term treatment of C. albicans infection with fluconazole, C. albicans has the potential to acquire fluconazole resistance. A promising approach to increase fluconazole's efficacy is identifying potential targets of drugs that can enhance the antifungal effect of fluconazole, or even make the drug fungicidal. In this review, we systematically provide a global overview of potential targets of drugs synergistic with fluconazole in C. albicans, identify new avenues for research on fluconazole potentiation, and highlight the promise of combinatorial strategies with fluconazole in combatting C. albicans infections.

PMID: 33587857 [PubMed - as supplied by publisher]

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