PERFORM Publications

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Title		Authors	PubMed ID
1	Association between risk of obstructive sleep apnea, inflammation and cognition after 45 years old in the Canadian Longitudinal Study on Aging	Cynthia Thompson	35245788 HKAP
2	Behavioural, physical, and psychological predictors of cortisol and C-reactive protein in breast cancer survivors: A longitudinal study	Lambert M; Sabiston CM; Wrosch C; Brunet J;	34589720 PSYCHOLOGY
3	An investigation into socio-demographic-, health-, and cancer-related factors associated with cortisol and C-reactive protein levels in breast cancer survivors: a longitudinal study.	Lambert M, Sabiston CM, Wrosch C, Brunet J	32488733 PSYCHOLOGY
4	Life after breast cancer: moving on, sitting down or standing still? A prospective study of Canadian breast cancer survivors.	Sabiston CM, Wrosch C, Fong AJ, Brunet J, Gaudreau P, O'Loughlin J, Meterissian S	30056387 PSYCHOLOGY

Title:	An investigation into socio-demographic-, health-, and cancer-related factors associated with cortisol and C-reactive protein levels in breast cancer survivors: a longitudinal study.
Authors:	Lambert M, Sabiston CM, Wrosch C, Brunet J
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32488733?dopt=Abstract
DOI:	10.1007/s12282-020-01113-z
Publication:	Breast cancer (Tokyo, Japan)
Keywords:	Breast cancer survivors; C-reactive protein; Correlates; Cortisol;
PMID:	32488733	Category:	Breast Cancer	Date Added:	2020-06-04
Dept Affiliation:	PSYCHOLOGY 1 School of Psychology, University of Ottawa, Ontario, Canada. 2 Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Canada. 3 Department of Psychology, Concordia University, Montreal, Canada. 4 School of Human Kinetics, University of Ottawa, Montpetit Hall, Room 339, Ottawa, ON, K1N 6N5, Canada. jennifer.brunet@uottawa.ca.

Description:

An investigation into socio-demographic-, health-, and cancer-related factors associated with cortisol and C-reactive protein levels in breast cancer survivors: a longitudinal study.

Breast Cancer. 2020 Jun 01;:

Authors: Lambert M, Sabiston CM, Wrosch C, Brunet J

Abstract

BACKGROUND: Breast cancer survivors (BCS) may exhibit dysregulated patterns of cortisol and C-reactive protein (CRP). The aims of this study were to describe BCS' cortisol and CRP levels over a 1-year period after treatment, and assess how levels relate to socio-demographic- (age, education level, marital status), health- (body mass index [BMI] category, menopausal status), and cancer-related factors (cancer stage, chemotherapy exposure, time since diagnosis).

METHODS: Participants (N?=?201) provided data at 3 months post-treatment (T1) and again 3, 6, 9, and 12 months later (T2-T5). At T1, participants completed self-report questionnaires and had their weight and height measured by a trained technician. At T1-T5, they provided five saliva samples at awakening, 30 min after awakening, 2:00 pm, 4:00 pm, and before bedtime on two nonconsecutive days to measure diurnal cortisol, and provided capillary whole blood to measure CRP. Data were analyzed using repeated-measure analyses of variance (ANOVAs) and mixed-design ANOVAs.

RESULTS: Diurnal cortisol and CRP levels fluctuated over time. In univariate models, older age and post-menopausal status were associated with higher cortisol and CRP levels, higher cancer stage and chemotherapy were associated with lower cortisol levels, and higher BMI category was associated with higher CRP levels. In adjusted models, age was no longer associated with CRP levels and shorter time since diagnosis was significantly associated with higher CRP levels.

CONCLUSIONS: Socio-demographic-, health-, and cancer-related factors may help identify BCS at risk of physiological dysregulation who need intervention. Identifying modifiable factors associated with cortisol and CRP will inform cancer care interventions.

PMID: 32488733 [PubMed - as supplied by publisher]

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