Keyword search (4,163 papers available)

"Bubble dynamics" Keyword-tagged Publications:

Title Authors PubMed ID
1 The effect of micro-vessel viscosity on the resonance response of a two-microbubble system Yusefi H; Helfield B; 39705920
BIOLOGY
2 The influence of inter-bubble spacing on the resonance response of ultrasound contrast agent microbubbles Yusefi H; Helfield B; 36223708
BIOLOGY

 

Title:The influence of inter-bubble spacing on the resonance response of ultrasound contrast agent microbubbles
Authors:Yusefi HHelfield B
Link:https://pubmed.ncbi.nlm.nih.gov/36223708/
DOI:10.1016/j.ultsonch.2022.106191
Publication:Ultrasonics sonochemistry
Keywords:Bubble dynamicsCavitationFinite elementNanobubblesNon-spherical vibrationNonlinear
PMID:36223708 Category: Date Added:2022-10-27
Dept Affiliation: BIOLOGY
1 Department of Physics, Concordia University, Montreal, Quebec H4B 1R6, Canada.
2 Department of Physics, Concordia University, Montreal, Quebec H4B 1R6, Canada; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada. Electronic address: brandon.helfield@concordia.ca.

Description:

Ultrasound-driven microbubbles, typically between 1 and 8 µm in diameter, are resonant scatterers that are employed as diagnostic contrast agents and emerging as potentiators of targeted therapies. Microbubbles are administered in populations whereby their radial dynamics - key to their effectiveness - are greatly affected by intrinsic (e.g. bubble size) and extrinsic (e.g. boundaries) factors. In this work, we aim to understand how two neighbouring microbubbles influence each other. We developed a finite element model of a system of two individual phospholipid-encapsulated microbubbles vibrating in proximity to each other to study the effect of inter-bubble distance on microbubble radial resonance response. For the case of two equal-sized and identical bubbles, each bubble exhibits a decrease between 7 and 10% in the frequency of maximum response (fMR) and an increase in amplitude of maximum response (AMR) by 9-11% as compared to its isolated response in free-space, depending on the bubble size examined. For a system of two unequal-sized microbubbles, the large bubble shows no significant change, however the smaller microbubble shows an increase in fMR by 7-11% and a significant decrease in AMR by 38-52%. Furthermore, in very close proximity the small bubble shows a secondary off-resonance peak at the corresponding fMR of its larger companion microbubble. Our work suggests that frequency-dependent microbubble response is greatly affected by the presence of another bubble, which has implications in both imaging and therapy applications. Furthermore, our work suggests a mechanism by which nanobubbles show significant off-resonance vibrations in the clinical frequency range, a behaviour that has been observed experimentally but heretofore unexplained.





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