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PubMed Publications| Keyword search (4,164 papers available) |  |
"Bacteria" Keyword-tagged Publications:
| Title: | Dual acting acid-cleavable self-assembling prodrug from hyaluronic acid and ciprofloxacin: A potential system for simultaneously targeting bacterial infections and cancer | ||||
| Authors: | Ibrahim UH, Devnarain N, Mohammed M, Omolo CA, Gafar MA, Salih M, Pant A, Shunmugam L, Mocktar C, Khan R, Oh JK, Govender T | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/36150574/ | ||||
| DOI: | 10.1016/j.ijbiomac.2022.09.173 | ||||
| Publication: | International journal of biological macromolecules | ||||
| Keywords: | Antibacterial; Anticancer; Ciprofloxacin; Hyaluronic acid; Micelles; Prodrug; Self-assembly; pH-responsive; | ||||
| PMID: | 36150574 | Category: | Date Added: | 2022-09-24 | |
| Dept Affiliation: |
CHEMBIOCHEM
1 Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa. 2 Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa; United States International University-Africa, School of Pharmacy and Health Sciences, Department of Pharmaceutics, P. O. Box 14634-00800, Nairobi, Kenya. Electronic address: comolo@usiu.ac.ke. 3 Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa. 4 Department of Chemistry and Biochemistry, School of Arts and Sciences, Concordia University, 7141 Sherbrooke St. W., Montreal, QC, Canada. 5 Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa. Electronic address: govenderth@ukzn.ac.za |
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Description: |
The incidence and of bacterial infections, and resulting mortality, among cancer patients is growing dramatically, worldwide. Several therapeutics have been reported to have dual anticancer and antibacterial activity. However, there is still an urgent need to develop new drug delivery strategies to improve their clinical efficacy. Therefore, this study aimed to develop a novel acid cleavable prodrug (HA-Cip) from ciprofloxacin and hyaluronic acid to simultaneously enhance the anticancer and antibacterial properties of Cip as a superior drug delivery system. HA-Cip was synthesised and characterised (FT-IR, HR-MS, and H1 NMR). HA-Cip generated stable micelles with an average particle size, poly dispersion index (PDI) and zeta potential (ZP) of 237.89 ± 25.74 nm, 0.265 ± 0.013, and -17.82 ± 1.53 mV, respectively. HA-Cip showed =80 % cell viability against human embryonic kidney 293 cells (non-cancerous cells), ?0.3 % haemolysis; and a faster pH-responsive ciprofloxacin release at pH 6.0. HA-Cip showed a 5.4-fold improvement in ciprofloxacin in vitro anticancer activity against hepatocellular cancer (HepG2) cells; and enhanced in vitro antibacterial activity against Escherichia coli and Klebsiella pneumoniae at pH 6.0. Our findings show HA-Cip as a promising prodrug for targeted delivery of ciprofloxacin to efficiently treat bacterial infections associated, and/or co-existing, with cancer. |
