Keyword search (4,164 papers available)

"Accumbens" Keyword-tagged Publications:

Title Authors PubMed ID
1 Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats Algallal HE; Laplante I; Casale D; Najafipashaki S; Pomerleau A; Paquette T; Samaha AN; 41372546
PSYCHOLOGY
2 Neural correlates of recall and extinction in a rat model of appetitive Pavlovian conditioning Brown A; Villaruel FR; Chaudhri N; 36496079
PSYCHOLOGY
3 The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands Howland JG; Ito R; Lapish CC; Villaruel FR; 35131398
PSYCHOLOGY
4 Corticostriatal suppression of appetitive Pavlovian conditioned responding Villaruel FR; Martins M; Chaudhri N; 34880119
PSYCHOLOGY
5 Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior. Lafferty CK, Britt JP 32269514
CSBN
6 Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Lafferty CK, Yang AK, Mendoza JA, Britt JP 32187545
CSBN
7 Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability. Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP 31699294
CSBN
8 Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors. Voyer D, Lévesque D, Rompré PP 27267684
CSBN
9 Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment. Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN 28522313
CSBN

 

Title:Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.
Authors:Yang AK,  Mendoza JA,  Lafferty CK,  Lacroix F,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/31699294?dopt=Abstract
DOI:10.1016/j.biopsych.2019.09.007
Publication:Biological psychiatry
Keywords:Feeding behavior;  Hedonic processing;  Hippocampus;  Nucleus accumbens;  Optogenetics;  Palatability; 
PMID:31699294 Category:Biol Psychiatry Date Added:2019-11-09
Dept Affiliation: CSBN
1 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
2 Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
3 Department of Psychology, McGill University, Montreal, Quebec, Canada.
4 Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability.

Biol Psychiatry. 2019 Sep 19;:

Authors: Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP

Abstract

BACKGROUND: Insight into the neural basis of hedonic processing has come from studies of food palatability in rodents. Pharmacological manipulations of the nucleus accumbens shell (NAcSh) have repeatedly been demonstrated to increase hedonic taste reactivity, yet the contribution of specific NAcSh circuit components is unknown.

METHODS: Bidirectional optogenetic manipulations were targeted to the principal NAcSh projection neurons and afferent pathways in mice during free feeding assays. Number of licks per bout of consumption was used as a measure of food palatability as it was confirmed to track sucrose concentration and subjective flavor preferences.

RESULTS: Photoinhibition of NAcSh neurons, whether general or cell-type specific, was found to alter consumption without affecting its hedonic impact. Among the principal excitatory afferent pathways, we showed that ventral hippocampal (vHipp) input alone enhances palatability upon low-frequency photostimulation time-locked to consumption. This enhancement in palatability was independent of opioid signaling and not recapitulated by NAcSh or dopamine neuron photostimulation. We further demonstrated that vHipp input photostimulation is sufficient to condition a flavor preference, while its inhibition impedes sucrose-driven flavor preference conditioning.

CONCLUSIONS: These results demonstrate a novel contribution of vHipp-NAcSh pathway activity to palatability that may relate to its innervation of a particular region or neuronal ensemble in the NAcSh. These findings are consistent with the evidence that vHipp-NAcSh activity is relevant to the pathophysiology of anhedonia and depression as well as the increasing appreciation of hippocampal involvement in people's food pleasantness ratings, hunger, and weight.

PMID: 31699294 [PubMed - as supplied by publisher]




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