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PubMed Publications| Keyword search (4,164 papers available) |  |
Concordia Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an α7 Nicotinic Acetylcholine Receptor-Dependent Manner | Gholizadeh F; Hajiaghayi M; Rahbari N; Choi JS; Heidt S; Como A; Kazerouni M; Kargar M; Pinard-LaRoche A; Shih SCC; Darlington PJ; | 41928597 SOH |
| 2 | Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner | Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ; | 41906691 SOH |
| 3 | Strengthening and Targeted Rehabilitation for Optimal Neuromuscular Gains for chronic BACK pain (STRONG-BACK): protocol for a randomised controlled trial in participants with primary nociceptive pain drivers | Fortin M; Rosenstein B; Bertrand C; Vaillancourt N; Wright A; Montpetit C; Macedo L; Elliott J; Cook CE; Tousignant-Laflamme Y; Ma J; Pagé MG; Dover G; Dang-Vu TT; Weber MH; | 41876162 SOH |
| 4 | A Fully Virtual Graded Exertion Test Is Safe and Feasible in Symptomatic and Asymptomatic Children With Concussion | Coupal J; Shabanova D; Gagnon I; Grilli L; Beaulieu C; Teel E; | 41816309 SOH |
| 5 | Achilles tendon ultrasound-derived properties of the dominant and non-dominant jumping leg of university basketball athletes: relation with performance, range of motion, and injury | Soontjens O; Busner J; Fortin M; | 41783785 SOH |
| 6 | Exploring correlates of weight bias among university students in diverse programs | Jeanningros A; Côté M; Forouhar V; Aimé A; Lavallière M; Blackburn P; Maïano C; Alberga AS; Baillot A; | 41718586 SOH |
| 7 | Beyond the wound: A scoping review of the psychosocial impact of diabetes-related foot ulcers | Hanlon M; McGuire BE; MacGilchrist C; Kirwan E; Neachtain DN; Dhatariya K; Blanchette V; Durand H; Dragomir A; McIntosh C; | 41721498 SOH |
| 8 | The effect of postoperative rehabilitation on outcomes in patients with degenerative cervical myelopathy (DCM): A systematic review | Montpetit C; Kobaisi A; Lantz JM; Chauhan RV; Anderson DB; Fortin M; | 41693706 SOH |
| 9 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 10 | How vigilance states influence source imaging of physiological brain oscillations: evidence from intracranial EEG | Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B; | 41687693 SOH |
| 11 | The effectiveness of Cognitive behavioral therapy for insomnia on sleep EEG hyperarousal: a multicentric polysomnographic study | Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L; | 41688421 SOH |
| 12 | Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease | Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41680492 SOH |
| 13 | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults | Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41543005 SOH |
| 14 | Aquatic therapy compared to standard care for chronic low back pain: a randomized controlled trial | Vaillancourt N; Montpetit C; Rosenstein B; Fortin M; | 41527881 SOH |
| 15 | The ELEVATE-LBP consortium: exercise &, evidence to lead effective vital action in translating excellence for low back pain prevention | Sheeran L; McIlroy S; Wong AYL; Anderson DB; Samartzis D; Bogaert L; Domokos B; Spang C; Fortin M; Hodges PW; Bizzini M; Dvorák J; | 41507623 SOH |
| 16 | Preexisting Mental Health Disorders Are Associated With Acute Clinical Presentation and Longitudinal Recovery Trajectories in Adolescents With Concussion | Iuliano SG; Gagnon IJ; Iverson GL; Cook NE; Zemek R; Teel EF; | 41505351 SOH |
| 17 | The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function | Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 41452711 SOH |
| 18 | Pontine Functional Connectivity Gradients | Rousseau PN; Bazin PL; Steele CJ; | 41420671 SOH |
| 19 | Patterns of Structural Disconnection Driving Proprioceptive Deficits in Chronic Stroke | Kaeja M; Gajiyeva L; Iturria-Medina Y; Villringer A; Sehm B; Steele C; | 41392885 SOH |
| 20 | Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition | Potvin-Jutras Z; Tremblay PL; Mohammadi H; Villeneuve S; Spreng RN; Gauthier CJ; | 41353310 SOH |
| 21 | The Effect of a 10-Week Electromyostimulation Intervention with the StimaWELL 120MTRS System on Multifidus Morphology and Function in Chronic Low Back Pain Patients: A Randomized Controlled Trial | Wolfe D; Rosenstein B; Dover G; Boily M; Fortin M; | 41283552 SOH |
| 22 | Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy | Xie K; Sahlas E; Ngo A; Chen J; Arafat T; Royer J; Zhou Y; Rodríguez-Cruces R; Dascal A; Caldairou B; Fadaie F; Barnett A; Audrain S; Larivière S; Caciagli L; Pana R; Weil AG; Grova C; Frauscher B; Schrader DV; Zhang Z; Concha L; Bernasconi A; Bernasconi N; Bernhardt BC; | 41258102 SOH |
| 23 | Effects of cognitive-behavioral therapy for insomnia during sedative-hypnotics withdrawal on sleep and cognition in older adults | Barbaux L; Cross NE; Perrault AA; Es-Sounni M; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Tannenbaum C; Guimond A; Grenier S; Gouin JP; Dang-Vu TT; | 41092866 SOH |
| 24 | Cerebral small vessel disease lesion segmentation methods: A systematic review | Phelps J; Singh M; McCreary CR; Dallaire-Théroux C; Stein RG; Potvin-Jutras Z; Guan DX; Wu JD; Metz A; Smith EE; | 41080650 SOH |
| 25 | The legality of weight discrimination in Canada: an environmental scan of case law and the limits of Canadian legislation | Nutter S; Waugh R; McEachran E; Toor A; Shelley J; Alberga AS; Forhan M; Kirk SF; Nagpal TS; Patton I; Ramos Salas X; Russell-Mayhew S; | 41029703 SOH |
| 26 | The PREVENT-AD cohort: Accelerating Alzheimer s disease research and treatment in Canada and beyond | Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Fajardo Valdez A; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda-Brown C; Tardif CL; Gauthier CJ; Descoteaux M; Dadar M; Vachon-Presseau É; Baril AA; Ducharme S; Montembeault M; Geddes MR; Soucy JP; Rajah N; Laforce R; Bocti C; Davatzikos C; Bellec L; Rosa-Neto P; Baillet S; Evans AC; Collins DL; Chakravarty MM; Blennow K; Zetterbe | 41020412 SOH |
| 27 | Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial | Pieruccini-Faria F; Son S; Zou G; Almeida QJ; Middleton LE; Bray NW; Lussier M; Shoemaker JK; Speechley M; Liu-Ambrose T; Burhan AM; Camicioli R; Li KZH; Fraser S; Berryman N; Bherer L; Montero-Odasso M; | 40966614 SOH |
| 28 | BOLD Long-Range Temporal Correlations Reflect Changes in Language and Depression Across Intensive Aphasia Therapy | Jäger AP; Steele CJ; Dreyer FR; Osterloh MR; Sadlon A; Nikulin V; Mohr B; Pulvermüller F; | 40927858 SOH |
| 29 | Development and Application of Children s Sex- and Age-Specific Fat-Mass and Muscle-Mass Reference Curves From Dual-Energy X-Ray Absorptiometry Data for Predicting Cardiometabolic Risk | Saputra ST; Van Hulst A; Henderson M; Brugiapaglia S; Faustini C; Kakinami L; | 40878792 SOH |
| 30 | Multivariate white matter microstructure alterations in older adults with coronary artery disease | Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ; | 40829939 SOH |
| 31 | The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss | Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S; | 40831565 SOH |
| 32 | Prioritising methodological research questions for scoping reviews, mapping reviews and evidence and gap maps for health research: a protocol for PROSPECT Delphi study | Pollock D; Hasanoff S; McBride G; Kanukula R; Tricco AC; Khalil H; Campbell F; Jia RM; Alexander L; Peters M; Vieira AM; Aromataris E; Nunn J; Saran A; Evans C; Godfrey C; Pieper D; de Moraes ÉB; Biesty L; Colquhoun H; Devane D; Toomey E; Clyne B; Davies E; Munn Z; | 40759523 SOH |
| 33 | The longitudinal effects of global and regional brain measurements on cognitive abilities | Hosseininasabnajar F; Kakinami L; | 40739300 SOH |
| 34 | Assessing quantitative MRI techniques using multimodal comparisons | Carter F; Anwander A; Johnson M; Goucha T; Adamson H; Friederici AD; Lutti A; Gauthier CJ; Weiskopf N; Bazin PL; Steele CJ; | 40705745 SOH |
| 35 | Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities? | Turner L; Wanasinghe AI; Brunori P; Santosa S; | 40533358 SOH |
| 36 | Visual Features in Stereo-Electroencephalography to Predict Surgical Outcome: A Multicenter Study | Abdallah C; Thomas J; Aron O; Avigdor T; Jaber K; Doležalová I; Mansilla D; Nevalainen P; Parikh P; Singh J; Beniczky S; Kahane P; Minotti L; Chabardes S; Colnat-Coulbois S; Maillard L; Hall J; Dubeau F; Gotman J; Grova C; Frauscher B; | 40519108 SOH |
| 37 | Morphological characteristics of the thoracolumbar fascia: relationship to chronic low back pain and back extension strength | Caron FP; Martin Smith C; Naghdi N; Iorio OC; Bertrand C; Fortin M; | 40498329 SOH |
| 38 | What is the role of non-surgical clinicians in the assessment and management of degenerative cervical myelopathy? - Insights from the RECODE-DCM peri-operative rehabilitation incubator | Chauhan RV; Demetriades AK; Boerger TF; Lantz JM; Treanor C; Kalsi-Ryan S; Kumar V; Wood L; Plener J; Wilson N; Fortin M; Ammendolia C; Paus A; Dhillon RS; Davies B; Fehlings MG; Anderson DB; | 40487873 SOH |
| 39 | Spectral and network investigation reveals distinct power and connectivity patterns between phasic and tonic REM sleep | Avigdor T; Peter-Derex L; Ho A; Schiller K; Wang Y; Abdallah C; Delaire E; Jaber K; Travnicek V; Grova C; Frauscher B; | 40394955 SOH |
| 40 | NIRSTORM: a Brainstorm extension dedicated to functional near-infrared spectroscopy data analysis, advanced 3D reconstructions, and optimal probe design | Delaire É; Vincent T; Cai Z; Machado A; Hugueville L; Schwartz D; Tadel F; Cassani R; Bherer L; Lina JM; Pélégrini-Issac M; Grova C; | 40375973 SOH |
| 41 | Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear-Avoidance Beliefs, Insomnia, and Spinal Degenerative Changes | Pinto SM; Cheung JPY; Samartzis D; Karppinen J; Zheng YP; Pang MYC; Fortin M; Wong AYL; | 40376565 SOH |
| 42 | Multiscale gradients of corticopontine structural connectivity | Rousseau PN; Bazin PL; Steele CJ; | 40355513 SOH |
| 43 | Aquatic exercise versus standard care on paraspinal muscle morphology and function in chronic low back pain patients: a randomized controlled trial | Rosenstein B; Montpetit C; Vaillancourt N; Dover G; Weiss C; Papula LA; Melek A; Fortin M; | 40328824 SOH |
| 44 | Mechanism of Injury and Clinical Recovery Outcomes Following Pediatric Concussion | Gudymenko A; Iuliano SG; Gagnon IJ; Iverson GL; Cook NE; Zemek R; Teel EF; | 40244878 SOH |
| 45 | Overweight and obesity in early childhood and obesity at 10 years of age: a comparison of World Health Organization definitions | Van Hulst A; Zheng S; Argiropoulos N; Ybarra M; Ball GDC; Kakinami L; | 40140102 SOH |
| 46 | Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility | Potvin-Jutras Z; Intzandt B; Mohammadi H; Liu P; Chen JJ; Gauthier CJ; | 40079560 SOH |
| 47 | Comparison of Combined Motor Control Training and Isolated Extensor Strengthening Versus General Exercise on Lumbar Paraspinal Muscle Health and Associations With Patient-Reported Outcome Measures in Chronic Low Back Pain Patients: A Randomized Controlled Trial | Rosenstein B; Rye M; Roussac A; Naghdi N; Macedo LG; Elliott J; DeMont R; Weber MH; Pepin V; Dover G; Fortin M; | 40066720 SOH |
| 48 | Combating childhood overweight and obesity: The role of Olympic Movement and bodily movement | Tam BT; Wan K; Santosa S; Cai Z; | 39991475 SOH |
| 49 | A database of magnetic resonance imaging-transcranial ultrasound co-registration | Alizadeh M; Collins DL; Kersten-Oertel M; Xiao Y; | 39920905 SOH |
| 50 | Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans | Costa DN; Santosa S; Jensen MD; | 39869194 SOH |
| 51 | Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach | Ali OBK; Vidal A; Grova C; Benali H; | 39804928 SOH |
| 52 | Patterns of Cerebellar-Cortical Structural Covariance Mirror Anatomical Connectivity of Sensorimotor and Cognitive Networks | Alasmar Z; Chakravarty MM; Penhune VB; Steele CJ; | 39791308 SOH |
| 53 | Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement | Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L; | 39739397 SOH |
| 54 | Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology | Hrtonova V; Nejedly P; Travnicek V; Cimbalnik J; Matouskova B; Pail M; Peter-Derex L; Grova C; Gotman J; Halamek J; Jurak P; Brazdil M; Klimes P; Frauscher B; | 39608298 SOH |
| 55 | Feeling safe: a critical look at the effect of neighborhood safety features and perceptions on childhood symptoms of depression | Infantino E; Barnett TA; Côté-Lussier C; Van Hulst A; Henderson M; Mathieu ME; Sabiston C; Kakinami L; | 39604905 SOH |
| 56 | The Immediate Effect of a Single Treatment of Neuromuscular Electrical Stimulation with the StimaWELL 120MTRS System on Multifidus Stiffness in Patients with Chronic Low Back Pain | Wolfe D; Dover G; Boily M; Fortin M; | 39594260 SOH |
| 57 | Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus | Plissonneau C; Santosa S; | 39553621 SOH |
| 58 | Weight-control compensatory behaviors patterns and correlates: a scoping review | Yuan TY; Bouzari N; Bains A; Cohen TR; Kakinami L; | 39469249 SOH |
| 59 | Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility | Potvin-Jutras Z; Intzandt B; Mohammadi H; Liu P; Chen JJ; Gauthier CJ; | 39416007 SOH |
| 60 | The effects of a 12-week combined motor control exercise and isolated lumbar extension intervention on lumbar multifidus muscle stiffness in individuals with chronic low back pain | Tornblom A; Naghdi N; Rye M; Montpetit C; Fortin M; | 39258113 SOH |
| 61 | Open access segmentations of intraoperative brain tumor ultrasound images | Behboodi B; Carton FX; Chabanas M; de Ribaupierre S; Solheim O; Munkvold BKR; Rivaz H; Xiao Y; Reinertsen I; | 39047165 SOH |
| 62 | Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region | Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S; | 39045668 SOH |
| 63 | EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy | Afnan J; Cai Z; Lina JM; Abdallah C; Delaire E; Avigdor T; Ros V; Hedrich T; von Ellenrieder N; Kobayashi E; Frauscher B; Gotman J; Grova C; | 38994740 SOH |
| 64 | A spatial perturbation framework to validate implantation of the epileptogenic zone | Jaber K; Avigdor T; Mansilla D; Ho A; Thomas J; Abdallah C; Chabardes S; Hall J; Minotti L; Kahane P; Grova C; Gotman J; Frauscher B; | 38897997 SOH |
| 65 | Comparing assessment methods of low back pain related disability in student circus artists: A cross-sectional study | Rossini B; Anstruther M; Fortin M; | 38848166 SOH |
| 66 | Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status | Wearn A; Tremblay SA; Tardif CL; Leppert IR; Gauthier CJ; Baracchini G; Hughes C; Hewan P; Tremblay-Mercier J; Rosa-Neto P; Poirier J; Villeneuve S; Schmitz TW; Turner GR; Spreng RN; | 38830849 SOH |
| 67 | DEXA Body Composition Asymmetry Analysis and Association to Injury Risk and Low Back Pain in University Soccer Players | Vaillancourt N; Montpetit C; Carile V; Fortin M; | 38791774 SOH |
| 68 | Arthritis is associated with high nutritional risk among older Canadian adults from the Canadian Longitudinal Study on Aging | Bennett R; Demmers TA; Plourde H; Arrey K; Armour B; Ferland G; Kakinami L; | 38734730 SOH |
| 69 | Paraspinal Muscle Changes in Individuals with and without Chronic Low Back Pain over a 4-Month Period: A Longitudinal MRI Study | Anstruther M; Sean M; Tétreault P; Fortin M; | 38541216 SOH |
| 70 | MVComp toolbox: MultiVariate Comparisons of brain MRI features accounting for common information across metrics | Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ; | 38463982 SOH |
| 71 | Decreased long-range temporal correlations in the resting-state functional magnetic resonance imaging blood-oxygen-level-dependent signal reflect motor sequence learning up to 2 weeks following training | Jäger AP; Bailey A; Huntenburg JM; Tardif CL; Villringer A; Gauthier CJ; Nikulin V; Bazin PL; Steele CJ; | 38124341 SOH |
| 72 | Effect of aquatic exercise versus standard care on paraspinal and gluteal muscles morphology in individuals with chronic low back pain: a randomized controlled trial protocol | Rosenstein B; Montpetit C; Vaillancourt N; Dover G; Khalini-Mahani N; Weiss C; Papula LA; Melek A; Fortin M; | 38110922 SOH |
| 73 | PILLAR: ParaspInaL muscLe segmentAtion pRoject - a comprehensive online resource to guide manual segmentation of paraspinal muscles from magnetic resonance imaging | Anstruther M; Rossini B; Zhang T; Liang T; Xiao Y; Fortin M; | 37996857 SOH |
| 74 | Compensatory health motivations and behaviors scale: Development, evaluation, psychometric properties and a preliminary validation | Sedemedes K; Knäuper B; Sadikaj G; Yuan TY; Wrosch C; Santosa S; Alberga AS; Kakinami L; | 37804879 SOH |
| 75 | Improvements in cardiorespiratory fitness, muscle strength and body composition to modest weight loss are similar in those with adult- versus childhood-onset obesity | Lucas Guimarães Almeida | 37794721 SOH |
| Title: | Development and Application of Children s Sex- and Age-Specific Fat-Mass and Muscle-Mass Reference Curves From Dual-Energy X-Ray Absorptiometry Data for Predicting Cardiometabolic Risk | ||||
| Authors: | Saputra ST, Van Hulst A, Henderson M, Brugiapaglia S, Faustini C, Kakinami L | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40878792/ | ||||
| DOI: | 10.1111/ijpo.70051 | ||||
| Publication: | Pediatric obesity | ||||
| Keywords: | adiposity; cardiometabolic risk; dual‐; energy x‐; ray absorptiometry; reference curves; youth; | ||||
| PMID: | 40878792 | Category: | Date Added: | 2025-08-29 | |
| Dept Affiliation: |
SOH
1 Department of Mathematics and Statistics, Concordia University, Quebec, Canada. 2 Ingram School of Nursing, McGill University, Quebec, Canada. 3 Centre de Recherche CHU Sainte-Justine, Université de Montréal, Quebec, Canada. 4 Department of Pediatrics, Université de Montréal, Quebec, Canada. 5 School of Public Health, Department of Social and Preventive Medicine, Université de Montréal, Montréal, Quebec, Canada. 6 School of Health, Concordia University, Quebec, Canada. |
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Description: |
Background: A dual-energy x-ray absorptiometry (DXA)-derived phenotype classification based on fat mass and muscle mass has been developed for adults. We extended this to a paediatric population. Methods: Children's (= 17 years) DXA data in NHANES (n = 6120) were used to generate sex- and age-specific deciles of appendicular skeletal muscle mass index and fat mass index with the Lambda Mu Sigma method. Four phenotypes (high [H] or low [L], adiposity [A] and muscle mass [M]: HA-HM, HA-LM, LA-HM, LA-LM) were identified based on being above/below the median compared to same-sex and same-age peers. These reference curves were applied to the QUALITY cohort (n = 630, 8-10 years of age in 2005) to assess whether the phenotypes correctly identified cardiometabolic risk at baseline, follow-up (2008-2010), and their longitudinal changes. Multiple linear regression models were adjusted for age, sex, and Tanner's stage. Results: Compared to the LA-HM reference group, the HA-HM phenotype was associated with less favourable HDL, triglycerides, and HOMA-IR at baseline and first follow-up, but not in their changes. The HA-LM phenotype was associated with less favourable HOMA-IR at baseline and first follow-up. Conclusions: Results suggest that phenotypes based on fat and muscle mass may have clinical utility in children and should be further investigated. |
