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Title		Authors	PubMed ID
1	A high-fidelity simulator for evaluation of hemodynamic response during cardiopulmonary resuscitation in hypogravity environments	Lord Z; Andrade C; Leroux L; Kadem L;	41741473 CHEMISTRY
2	Transcriptomic analysis suggests the inhibition of DNA damage repair in green alga Raphidocelis subcapitata exposed to roxithromycin.	Guo J, Bai Y, Chen Z, Mo J, Li Q, Sun H, Zhang Q	32505758 CHEMISTRY
3	Four Aromatic Intradiol Ring Cleavage Dioxygenases from Aspergillus niger.	Semana P, Powlowski J	31540981 CHEMISTRY
4	How Well Does the Hole-Burning Action Spectrum Represent the Site-Distribution Function of the Lowest-Energy State in Photosynthetic Pigment-Protein Complexes?	Zazubovich V, Jankowiak R	31265294 CHEMISTRY
5	Virtual screening, docking, and dynamics of potential new inhibitors of dihydrofolate reductase from Yersinia pestis.	Bastos Lda C, de Souza FR, Guimarães AP, Sirouspour M, Cuya Guizado TR, Forgione P, Ramalho TC, França TC	26494420 CHEMISTRY
6	Docking and molecular dynamics studies of peripheral site ligand-oximes as reactivators of sarin-inhibited human acetylcholinesterase.	de Almeida JS, Cuya Guizado TR, Guimarães AP, Ramalho TC, Gonçalves AS, de Koning MC, França TC	26612005 CHEMISTRY
7	O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.	O'Flaherty DK, Wilds CJ	26692563 CHEMISTRY
8	A bio-inspired synthesis of oxindoles by catalytic aerobic dual C-H functionalization of phenols.	Huang Z, Askari MS, Esguerra KVN, Dai TY, Kwon O, Ottenwaelder X, Lumb JP	29861988 CHEMISTRY
9	The Chemical Ecology of Predatory Soil Bacteria.	Findlay BL	27035738 CHEMISTRY
10	Mechanistic studies of new oximes reactivators of human butyryl cholinesterase inhibited by cyclosarin and sarin.	de Lima WE, Francisco A, da Cunha EF, Radic Z, Taylor P, França TC, Ramalho TC	27125569 CHEMISTRY

Title:	O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.
Authors:	O'Flaherty DK, Wilds CJ
Link:	https://www.ncbi.nlm.nih.gov/pubmed/26692563?dopt=Abstract
DOI:	10.1002/asia.201501253
Publication:	Chemistry, an Asian journal
Keywords:	DNA damage; DNA repair; O6-alkylguanine DNA alkyltransferase; intrastrand cross-link; oligonucleotides;
PMID:	26692563	Category:	Chem Asian J	Date Added:	2019-06-20
Dept Affiliation:	CHEMISTRY 1 Department of Chemistry&Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montréal, Québec (Canada. 2 Department of Chemistry&Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montréal, Québec (Canada. Chris.Wilds@concordia.ca.

Description:

O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.

Chem Asian J. 2016 Feb 18;11(4):576-83

Authors: O'Flaherty DK, Wilds CJ

Abstract

Oligonucleotides containing an alkylene intrastrand cross-link (IaCL) between the O(6) -atoms of two consecutive 2'-deoxyguanosines (dG) were prepared by solid-phase synthesis. UV thermal denaturation studies of duplexes containing butylene and heptylene IaCL revealed a 20?°C reduction in stability compared to the unmodified duplexes. Circular dichroism profiles of these IaCL DNA duplexes exhibited signatures consistent with B-form DNA. Human O(6) -alkylguanine DNA alkyltransferase (hAGT) was capable of repairing both IaCL containing duplexes with slightly greater efficiency towards the heptylene analog. Interestingly, repair efficiencies of hAGT towards these IaCL were lower compared to O(6) -alkylene linked IaCL lacking the 5'-3'-phosphodiester linkage between the connected 2'-deoxyguanosine residues. These results demonstrate that the proficiency of hAGT activity towards IaCL at the O(6) -atom of dG is influenced by the backbone phosphodiester linkage between the cross-linked residues.

PMID: 26692563 [PubMed - indexed for MEDLINE]

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