PERFORM Publications

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Title		Authors	PubMed ID
1	Behavioral weight management interventions in metabolic and bariatric surgery: A systematic review and meta-analysis investigating optimal delivery timing.	Julien CA, Lavoie KL, Ribeiro PAB, Dragomir AI, Mercier LA, Garneau PY, Pescarus R, Bacon SL	33403754 HKAP
2	Obesity and ageing: Two sides of the same coin.	Tam BT, Morais JA, Santosa S	32020741 PERFORM
3	Addressing weight bias and discrimination: moving beyond raising awareness to creating change.	Ramos Salas X, Alberga AS, Cameron E, Estey L, Forhan M, Kirk SFL, Russell-Mayhew S, Sharma AM	28994243 HKAP
4	From neutrophils to macrophages: differences in regional adipose tissue depots.	Dam V, Sikder T, Santosa S	26667065 PERFORM

Title:	Obesity and ageing: Two sides of the same coin.
Authors:	Tam BT, Morais JA, Santosa S
Link:	https://www.ncbi.nlm.nih.gov/pubmed/32020741?dopt=Abstract
DOI:	10.1111/obr.12991
Publication:	Obesity reviews : an official journal of the International Association for the Study of Obesity
Keywords:	age-related diseases; ageing; obesity;
PMID:	32020741	Category:	Obes Rev	Date Added:	2020-02-06
Dept Affiliation:	PERFORM 1 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Quebec, Montreal, Canada. 2 Metabolism, Obesity, and Nutrition Lab, PERFORM Centre, Concordia University, Quebec, Montreal, Canada. 3 Division of Geriatric Medicine and Research Institute, McGill University Health Centre, Quebec, Montreal, Canada. 4 Research Centre, Centre intégré universitarie de santé et de services sociaux du Nord-de-I'Île-de-Montréal, Hôpital du Sacré-Cœur de Monréal (CIUSS-NIM, HSCM), Quebec, Montreal, Canada.

Description:

Obesity and ageing: Two sides of the same coin.

Obes Rev. 2020 Feb 05;:

Authors: Tam BT, Morais JA, Santosa S

Abstract

Conditions and comorbidities of obesity mirror those of ageing and age-related diseases. Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic integrity, impaired mitochondrial function, accumulation of intracellular macromolecules, weakened immunity, shifts in tissue and body composition, and enhanced systemic inflammation. Moreover, it has been shown that obesity reduces life expectancy by 5.8 years in men and 7.1 years in women after the age of 40. Shorter life expectancy could be because obesity holistically accelerates ageing at multiple levels. Besides jeopardizing nuclear DNA and mitochondrial DNA integrity, obesity modifies the DNA methylation pattern, which is associated with epigenetic ageing in different tissues. Additionally, other signs of ageing are seen in individuals with obesity including telomere shortening, systemic inflammation, and functional declines. This review aims to show how obesity and ageing are "two sides of the same coin" through discussing how obesity predisposes an individual to age-related conditions, illness, and disease. We will further demonstrate how the mechanisms that perpetuate the early-onset of chronic diseases in obesity parallel those of ageing.

PMID: 32020741 [PubMed - as supplied by publisher]

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