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"Neuroscience" Category Publications:

Title Authors PubMed ID
1 TMS and H1-MRS measures of excitation and inhibition following lorazepam administration. Ferland MC, Therrien-Blanchet JM, Proulx S, Klees-Themens G, Bacon BA, Vu TTD, Théoret H 33246064
PERFORM
2 Prefrontal Cortex and Multiparity in Lactation. Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD 31437474
CSBN
3 17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo. Shams WM, Sanio C, Quinlan MG, Brake WG 27256507
PSYCHOLOGY
4 Effect of electrolytic lesions of the dorsal diencephalic conduction system on the distribution of Fos-like immunoreactivity induced by rewarding electrical stimulation. Fakhoury M, Voyer D, Lévesque D, Rompré PP 27514573
CSBN
5 Dopamine Signaling Is Critical for Supporting Cue-Driven Behavioral Control. Iordanova MD 31103706
PSYCHOLOGY
6 Dopaminergic enhancement of excitatory synaptic transmission in layer II entorhinal neurons is dependent on D₁-like receptor-mediated signaling. Glovaci I, Caruana DA, Chapman CA 24220689
PSYCHOLOGY
7 Serotonin 5-HT1A Receptor-Mediated Reduction of Excitatory Synaptic Transmission in Layers II/III of the Parasubiculum. Carter F, Chapman CA 30902681
PSYCHOLOGY

 

Title:Serotonin 5-HT1A Receptor-Mediated Reduction of Excitatory Synaptic Transmission in Layers II/III of the Parasubiculum.
Authors:Carter F,  Chapman CA
Link:https://www.ncbi.nlm.nih.gov/pubmed/30902681?dopt=Abstract
Publication:
Keywords:
PMID:30902681 Category:Neuroscience Date Added:2019-05-31
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Québec, Canada H4B 1R6.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Québec, Canada H4B 1R6. Electronic address: andrew.chapman@concordia.ca.

Description:

Serotonin 5-HT1A Receptor-Mediated Reduction of Excitatory Synaptic Transmission in Layers II/III of the Parasubiculum.

Neuroscience. 2019 May 15;406:325-332

Authors: Carter F, Chapman CA

Abstract

Serotonin (5-HT) has important effects on cognitive function within the hippocampal region where it modulates membrane potential and excitatory and inhibitory synaptic transmission. Here, we investigated how 5-HT modulates excitatory synaptic strength in layers II/III of the parasubiculum in rat brain slices. Bath-application of 1 or 10?µM 5-HT resulted in a strong, dose-dependent, and reversible reduction in the amplitude of field excitatory postsynaptic potentials (fEPSPs) recorded in the parasubiculum. The 5-HT reuptake blocker citalopram (10?µM) also reduced fEPSP amplitudes, indicating that 5-HT released within the slice inhibits synaptic transmission. The reduction of fEPSPs induced by 5-HT was blocked by the 5-HT1A receptor blocker NAN-190 (10?µM), but not by the 5-HT7 receptor blocker SB-269970 (10?µM). Moreover, the 5-HT1A agonist 8-OH-DPAT induced a reduction of fEPSP amplitude similar to that induced by 5-HT. The reduction was prevented by the 5-HT1A receptor blocker NAN-190. The reduction in fEPSPs induced by either 5-HT or by 8-OH-DPAT was accompanied by an increase in paired-pulse ratio, suggesting that it is due mainly to reduced glutamate release. Our data suggest that the effects of serotonin on cognitive function may depend in part upon a 5-HT1A-mediated reduction of excitatory synaptic transmission in the parasubiculum. This may also affect synaptic processing in the entorhinal cortex, which receives the major output projection of the parasubiculum.

PMID: 30902681 [PubMed - in process]




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