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"J Psychiatry Neurosci" Category Publications:

Title Authors PubMed ID
1 Why did the kitten cross the road? A meditation on positive versus negative reinforcement in addiction. Leyton M 33497168
CSBN
2 Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans. Smart K, Nagano-Saito A, Milella MS, Sakae DY, Favier M, Vigneault E, Louie L, Hamilton A, Ferguson SSG, Rosa-Neto P, Narayanan S, El Mestikawy S, Leyton M, Benkelfat C 32559027
CSBN
3 Cannabis legalization: Did we make a mistake? Update 2019 Leyton M 31452361
PSYCHOLOGY
4 Legalizing marijuana. Leyton M 26898727
CSBN
5 Cocaine cue-induced dopamine release in the human prefrontal cortex. Milella MS, Fotros A, Gravel P, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Reader AJ, Dagher A, Benkelfat C, Leyton M 26900792
CSBN
6 Are people with psychiatric disorders violent? Leyton M 29688170
CSBN
7 Are people with psychiatric disorders violent? Leyton M 29947604
CSBN
8 Neuroimaging tests for clinical psychiatry: Are we there yet? Leyton M, Kennedy SH 28639935
IMAGING
9 A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E 30693739
PSYCHOLOGY

 

Title:Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans.
Authors:Smart K,  Nagano-Saito A,  Milella MS,  Sakae DY,  Favier M,  Vigneault E,  Louie L,  Hamilton A,  Ferguson SSG,  Rosa-Neto P,  Narayanan S,  El Mestikawy S,  Leyton M,  Benkelfat C
Link:https://www.ncbi.nlm.nih.gov/pubmed/32559027?dopt=Abstract
DOI:10.1503/jpn.190162
Publication:Journal of psychiatry & neuroscience : JPN
Keywords:
PMID:32559027 Category:J Psychiatry Neurosci Date Added:2020-06-20
Dept Affiliation: CSBN
1 From the Department of Psychiatry, McGill University, Montreal, Que. (Smart, Nagano-Saito, Milella, Sakae, Favier, Vigneault, Louie, Rosa-Neto, El Mestikawy, Leyton, Benkelfat); the Douglas Mental Health University Institute, McGill University, Montreal, Que. (Smart, Sakae, Favier, Vigneault, Rosa-Neto, El Mestikawy); the Department of Cellular and Molecular Medicine, University of Ottawa, Ont. (Hamilton, Ferguson); the McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Que. (Rosa-Neto, Narayanan, Leyton, Benkelfat); the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Que. (Rosa-Neto, Narayanan, Leyton, Benkelfat); and the Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Que. (Leyton).

Description:

Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans.

J Psychiatry Neurosci. 2020 Jun 19;45(4):190162

Authors: Smart K, Nagano-Saito A, Milella MS, Sakae DY, Favier M, Vigneault E, Louie L, Hamilton A, Ferguson SSG, Rosa-Neto P, Narayanan S, El Mestikawy S, Leyton M, Benkelfat C

Abstract

Background: Glutamate transmission is implicated in drug-induced behavioural sensitization and the associated long-lasting increases in mesolimbic output. Metabotropic glutamate type 5 (mGlu5) receptors might be particularly important, but most details are poorly understood.

Methods: We first assessed in mice (n = 51, all male) the effects of repeated dextroamphetamine administration (2.0 mg/kg, i.p.) on locomotor activity and binding of the mGlu5 ligand [3H]ABP688. In a parallel study, in 19 stimulant-drug-naïve healthy human volunteers (14 female) we administered 3 doses of dextroamphetamine (0.3 mg/kg, p.o.) or placebo, followed by a fourth dose 2 weeks later. We measured [11C]ABP688 binding using positron emission tomography before and after the induction phase. We assessed psychomotor and behavioural sensitization using speech rate, eye blink rate and self-report. We measured the localization of mGlu5 relative to synaptic markers in mouse striatum using immunofluorescence.

Results: We observed amphetamine-induced psychomotor sensitization in mice and humans. We did not see group differences in mGlu5 availability following 3 pre-challenge amphetamine doses, but group differences did develop in mice administered 5 doses. In mice and humans, individual differences in mGlu5 binding after repeated amphetamine administration were negatively correlated with the extent of behavioural sensitization. In drug-naïve mice, mGlu5 was expressed at 67% of excitatory synapses on dendrites of striatal medium spiny neur.

Limitations: Correlational results should be interpreted as suggestive because of the limited sample size. We did not assess sex differences.

Conclusion: Together, these results suggest that changes in mGlu5 availability are not part of the earliest neural adaptations in stimulant-induced behavioural sensitization, but low mGlu5 binding might identify a higher propensity for sensitization.

PMID: 32559027 [PubMed - as supplied by publisher]




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