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Title		Authors	PubMed ID
1	Description, evaluation and scale-up potential of a model for rapid access to early intervention for psychosis.	MacDonald K, Malla A, Joober R, Shah JL, Goldberg K, Abadi S, Doyle M, Iyer SN	29582562 CONCORDIA
2	Early parent-child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16-year prospective cohort study.	Doucette S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A	25356767 PSYCHOLOGY
3	Early exposure to parental bipolar disorder and risk of mood disorder: the Flourish Canadian prospective offspring cohort study.	Goodday S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A	26486425 PSYCHOLOGY

Title:	Early exposure to parental bipolar disorder and risk of mood disorder: the Flourish Canadian prospective offspring cohort study.
Authors:	Goodday S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A
Link:	https://www.ncbi.nlm.nih.gov/pubmed/26486425?dopt=Abstract
DOI:	10.1111/eip.12291
Publication:	Early intervention in psychiatry
Keywords:	bipolar disorder; early development; high-risk offspring; mood disorder; sensitive period;
PMID:	26486425	Category:	Early Interv Psychiatry	Date Added:	2019-06-07
Dept Affiliation:	PSYCHOLOGY 1 Department of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. 2 Department of Mathematics & Statistics, University of Guelph, Guelph, Canada. 3 Department of Psychiatry, University of Toronto, Toronto, Canada. 4 Mood Disorders Centre of Ottawa, University of Ottawa Health Services, Ottawa, Ontario, Canada. 5 Department of Psychology, Concordia University, Montreal, Quebec, Canada. 6 Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.

Description:

Early exposure to parental bipolar disorder and risk of mood disorder: the Flourish Canadian prospective offspring cohort study.

Early Interv Psychiatry. 2018 04;12(2):160-168

Authors: Goodday S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A

Abstract

AIM: Exposure to postnatal parental depression is associated with offspring mood disorder later in life; however, little is known about exposure to parental bipolar disorder (BD) and subsequent risk of psychopathology. The aim of this study was to determine the association between the duration, severity and timing of exposure to parental BD in early childhood and subsequent risk of mood disorder.

METHODS: 189 offspring of a parent with BD completed annual assessments following Kiddie Schedule for Affective Disorders (KSADS) format semistructured interviews as part of an ongoing 16-year prospective cohort study. Clinical data from the affected parents were collected over the first decade of their offspring's life using SADS-L format semistructured interviews and coded using the Affective Morbidity Index (AMI).

RESULTS: A longer duration of exposure to parental BD was associated with a 1.5-fold risk of any psychopathology (95% confidence interval (CI): 1.0-2.3) and a 2.5-fold increased risk of substance use disorders (95% CI: 1.2-5.3). Exposure during the first 2 years of life was significantly associated with the risk of mood disorder (hazard ratio (HR): 1.1, 95% CI: 1.0-1.2), whereas exposure later in childhood was not.

CONCLUSIONS: The duration of exposure to active parental BD in childhood is an important risk factor for the subsequent development of mood and non-mood psychopathology risk in offspring. These findings emphasize the importance of effective treatment of parents with BD to help both themselves and their children, especially early in development.

PMID: 26486425 [PubMed - in process]

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