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PubMed Publications| Keyword search (4,163 papers available) |  |
"Chembiochem" Category Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing. | Copp W, Pontarelli A, Wilds CJ | 33506614 CHEMBIOCHEM |
| 2 | AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker. | O'Flaherty DK, Wilds CJ | 28980757 CHEMBIOCHEM |
| 3 | O4 -Alkylated-2-Deoxyuridine Repair by O6 -Alkylguanine DNA Alkyltransferase is Augmented by a C5-Fluorine Modification | Lauralicia Sacre | 29243336 CERMM |
| Title: | O4 -Alkylated-2-Deoxyuridine Repair by O6 -Alkylguanine DNA Alkyltransferase is Augmented by a C5-Fluorine Modification | ||||
| Authors: | Lauralicia Sacre | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/29243336/ | ||||
| DOI: | 10.1002/cbic.201700660 | ||||
| Publication: | Chembiochem : a European journal of chemical biology | ||||
| Keywords: | |||||
| PMID: | 29243336 | Category: | Chembiochem | Date Added: | 2019-05-31 |
| Dept Affiliation: |
CERMM
1 Department of Chemistry and Biochemistry and, Centre for Research in Molecular Modeling (CERMM), Concordia University, 7141 Sherbrooke St. West, Montréal, Québec, H4B 1R6, Canada. 2 Present address: Howard Hughes Medical Institute, Department of Molecular Biology and, Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA. |
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Description: |
Oligonucleotides containing various adducts, including ethyl, benzyl, 4-hydroxybutyl and 7-hydroxyheptyl groups, at the O4 atom of 5-fluoro-O4 -alkyl-2'-deoxyuridine were prepared by solid-phase synthesis. UV thermal denaturation studies demonstrated that these modifications destabilised the duplex by approximately 10 °C, relative to the control containing 5-fluoro-2'-deoxyuridine. Circular dichroism spectroscopy revealed that these modified duplexes all adopted a B-form DNA structure. O6... |
