Keyword search (4,163 papers available)

"de Zavalia N" Authored Publications:

Title Authors PubMed ID
1 Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner de Zavalia N; Schoettner K; Goldsmith JA; Solis P; Ferraro S; Parent G; Amir S; 34702951
PSYCHOLOGY
2 In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders Ferraro S; de Zavalia N; Belforte N; Amir S; 34650409
CSBN
3 The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R 31522764
CSBN
4 Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain. Frederick A, Goldsmith J, de Zavalia N, Amir S 28423013
BIOLOGY
5 Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N 25915475
CSBN
6 Exploring the role of locomotor sensitization in the circadian food entrainment pathway. Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S 28301599
PSYCHOLOGY
7 mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R; 29555746
CSBN

 

Title:Light-regulated translational control of circadian behavior by eIF4E phosphorylation.
Authors:Cao R,  Gkogkas CG,  de Zavalia N,  Blum ID,  Yanagiya A,  Tsukumo Y,  Xu H,  Lee C,  Storch KF,  Liu AC,  Amir S,  Sonenberg N
Link:https://www.ncbi.nlm.nih.gov/pubmed/25915475?dopt=Abstract
Publication:
Keywords:
PMID:25915475 Category:Nat Neurosci Date Added:2019-05-31
Dept Affiliation: CSBN
1 Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Canada.
2 Patrick Wild Centre, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Canada.
4 Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
5 Department of Biological Sciences, University of Memphis, Memphis, Tennessee, USA.
6 Department of Biomedical Sciences, Neuroscience Program, College of Medicine, Florida State University, Tallahassee, Florida, USA.

Description:

Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

Nat Neurosci. 2015 Jun;18(6):855-62

Authors: Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Abstract

The circadian (~24 h) clock is continuously entrained (reset) by ambient light so that endogenous rhythms are synchronized with daily changes in the environment. Light-induced gene expression is thought to be the molecular mechanism underlying clock entrainment. mRNA translation is a key step of gene expression, but the manner in which clock entrainment is controlled at the level of mRNA translation is not well understood. We found that a light- and circadian clock-regulated MAPK/MNK pathway led to phosphorylation of the cap-binding protein eIF4E in the mouse suprachiasmatic nucleus of the hypothalamus, the locus of the master circadian clock in mammals. Phosphorylation of eIF4E specifically promoted translation of Period 1 (Per1) and Period 2 (Per2) mRNAs and increased the abundance of basal and inducible PER proteins, which facilitated circadian clock resetting and precise timekeeping. Together, these results highlight a critical role for light-regulated translational control in the physiology of the circadian clock.

PMID: 25915475 [PubMed - indexed for MEDLINE]




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