Keyword search (4,164 papers available)

"Yang AK" Authored Publications:

Title Authors PubMed ID
1 Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Lafferty CK, Yang AK, Mendoza JA, Britt JP 32187545
CSBN
2 Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability. Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP 31699294
CSBN
3 Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value. Mendoza JA, Lafferty CK, Yang AK, Britt JP 31693885
CSBN
4 Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption. Reed SJ, Lafferty CK, Mendoza JA, Yang AK, Davidson TJ, Grosenick L, Deisseroth K, Britt JP 30146308
PSYCHOLOGY

 

Title:Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.
Authors:Mendoza JA,  Lafferty CK,  Yang AK,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/31693885?dopt=Abstract
DOI:10.1016/j.celrep.2019.09.077
Publication:Cell reports
Keywords:calcium imaging;  dopamine;  expected value;  motivation;  optogenetics;  overexpectation;  reinforcement learning;  reward prediction error;  ventral tegmental area; 
PMID:31693885 Category:Cell Rep Date Added:2019-11-07
Dept Affiliation: CSBN
1 Department of Psychology, McGill University, Montreal, QC H3A 1B1, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada.
2 Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada.
3 Department of Psychology, McGill University, Montreal, QC H3A 1B1, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada; Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: jonathan.britt@mcgill.ca.

Description:

Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value.

Cell Rep. 2019 Nov 05;29(6):1429-1437.e3

Authors: Mendoza JA, Lafferty CK, Yang AK, Britt JP

Abstract

Cue-evoked midbrain dopamine (DA) neuron activity reflects expected value, but its influence on reward assessment is unclear. In mice performing a trial-based operant task, we test if bidirectional manipulations of cue or operant-associated DA neuron activity drive learning as a result of under- or overexpectation of reward value. We target optogenetic manipulations to different components of forced trials, when only one lever is presented, and assess lever biases on choice trials in the absence of photomanipulation. Although lever biases are demonstrated to be flexible and sensitive to changes in expected value, augmentation of cue or operant-associated DA signaling does not significantly alter choice behavior, and blunting DA signaling during any component of the forced trials reduces choice trial responses on the associated lever. These data suggest cue-evoked DA helps maintain cue-value associations but does not encode expected value as to set the benchmark against which received reward is judged.

PMID: 31693885 [PubMed - in process]




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