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PubMed Publications| Keyword search (4,163 papers available) |  |
"Wu C" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | New spectral indices for identifying large plastic accumulations in coastal waters with sentinel-2 imagery | Wu C; Chen Z; Peng C; An C; | 41406508 ENCS |
| 2 | Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22 | McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM; Ryan S; Raphael S; van Faassen H; Zafer A; Zhu Q; Maclean S; Chattopadhyay A; Gurnani K; Gilbert R; Gadoury C; Iqbal U; Fatehi D; Jezierski A; Huang J; Pon RA; Sigrist M; Holt RA; Nelson BH; Atkins H; Kekre N; Yung E; Webb J; Nielsen JS; Weeratna RD; | 38596311 BIOLOGY |
| 3 | Polarization and cell-fate decision facilitated by the adaptor Ste50p in Saccharomyces cerevisiae | Sharmeen N; Law C; Wu C; | 36538537 BIOLOGY |
| 4 | Role of tau protein on the photophysical properties of fluorescent carbon dots | Camilus NS; Lucas S; Wu C; Naccache R; Martic S; | 34971135 CONCORDIA |
| 5 | The adaptor protein Ste50 directly modulates yeast MAPK signaling specificity through differential connections of its RA domain. | Sharmeen N, Sulea T, Whiteway M, Wu C | 30650049 BIOLOGY |
| 6 | Comparison of Electronic and Physicochemical Properties between Imidazolium-Based and Pyridinium-Based Ionic Liquids. | Wu C, De Visscher A, Gates ID | 29889524 ENCS |
| Title: | Role of tau protein on the photophysical properties of fluorescent carbon dots | ||||
| Authors: | Camilus NS, Lucas S, Wu C, Naccache R, Martic S | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34971135/ | ||||
| DOI: | 10.1002/alz.058430 | ||||
| Publication: | |||||
| Keywords: | |||||
| PMID: | 34971135 | Category: | Date Added: | 2021-12-31 | |
| Dept Affiliation: |
CONCORDIA
1 Trent University, Peterborough, ON, Canada. 2 Oakland University, Rochester Hills, MI, USA. 3 Concordia University, Montreal, QC, Canada. |
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Description: |
Background: Globally, a number of individuals who live with Alzheimer's disease (AD), an incurable and debilitating disease, is increasing. Tau protein has a structural role, maintains integrity of microtubules and is one of the underlying causes of the tauopathies [1]. It is unfolded and highly soluble under physiological conditions. However, tau protein undergoes post-translational modifications like phosphorylation and aggregates causing cell death and spreading. In vitro, tau aggregation is typically evaluated using spectroscopic and microscopic methods. Methods: Herein, we propose to evaluate the use of carbon dots, an important type of fluorescent nanoparticles, as potential probes for tau protein aggregation. Dual fluorescent carbon dots were used in combination with tau protein, prior and post aggregation. Aggregation of the longest isoform of tau441 was induced using heparin. The fluorescence spectroscopy was used to analyze photophysical properties of carbon dots as a function of monomeric and aggregated tau. Results: The fluorescence quenching was observed for all protein containing samples, and was dependent on the aging time used for aggregation. The performance of carbon dots was compared to the standard Thioflavin T assay. Conclusion: Data indicate that nanomaterials may be useful platforms for sensing application targeting biomarkers of neurodegenerative diseases. References: [1] a. Andronesi, O. C., Bergen, M. V., Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., & Baldus, M. (2008). Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy. Journal of the American Chemical Society, 130(18), 5922-5928.; b. Jeganathan, S., Hascher, A., Chinnathambi, S., Biernat, J., Mandelkow, E. M., & Mandelkow, E. (2008). Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. Journal of Biological Chemistry, 283(46), 32066-32076. |
