BookR: School of Health Core Facilities Booking
PubMed Publications| Keyword search (4,164 papers available) |  |
"Thomas J" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Visual Features in Stereo-Electroencephalography to Predict Surgical Outcome: A Multicenter Study | Abdallah C; Thomas J; Aron O; Avigdor T; Jaber K; Doležalová I; Mansilla D; Nevalainen P; Parikh P; Singh J; Beniczky S; Kahane P; Minotti L; Chabardes S; Colnat-Coulbois S; Maillard L; Hall J; Dubeau F; Gotman J; Grova C; Frauscher B; | 40519108 SOH |
| 2 | A spatial perturbation framework to validate implantation of the epileptogenic zone | Jaber K; Avigdor T; Mansilla D; Ho A; Thomas J; Abdallah C; Chabardes S; Hall J; Minotti L; Kahane P; Grova C; Gotman J; Frauscher B; | 38897997 SOH |
| 3 | Targeted density electrode placement achieves high concordance with traditional high-density EEG for electrical source imaging in epilepsy | Horrillo-Maysonnial A; Avigdor T; Abdallah C; Mansilla D; Thomas J; von Ellenrieder N; Royer J; Bernhardt B; Grova C; Gotman J; Frauscher B; | 37704552 PERFORM |
| 4 | Erratum to: Methods for evaluating medical tests and biomarkers. | Gopalakrishna G, Langendam M, Scholten R, Bossuyt P, Leeflang M, Noel-Storr A, Thomas J, Marshall I, Wallace B, Whiting P, Davenport C, Leeflang M, GopalaKrishna G, de Salis I, Mallett S, Wolff R, Whiting P, Riley R, Westwood M, Kleinen J, Collins G, Reitsma H, Moons K, Zapf A, Hoyer A, Kramer K, Kuss O, Ensor J, Deeks JJ, Martin EC, Riley RD, Rücker G, Steinhauser S, Schumacher M, Riley R, Ensor J, Snell K, Willis B, Debray T, Moons K, Deeks J, Collins G, di Ruffano LF, Willis B, Davenport C, Mallett S, Ta | 31095132 NA |
| Title: | A spatial perturbation framework to validate implantation of the epileptogenic zone | ||||
| Authors: | Jaber K, Avigdor T, Mansilla D, Ho A, Thomas J, Abdallah C, Chabardes S, Hall J, Minotti L, Kahane P, Grova C, Gotman J, Frauscher B | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/38897997/ | ||||
| DOI: | 10.1038/s41467-024-49470-z | ||||
| Publication: | Nature communications | ||||
| Keywords: | |||||
| PMID: | 38897997 | Category: | Date Added: | 2024-06-20 | |
| Dept Affiliation: |
SOH
1 Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada. 2 Department of Biomedical Engineering, Duke Pratt School of Engineering, Durham, NC, USA. 3 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montréal, QC, Canada. 4 Neurophysiology Unit, Institute of Neurosurgery Dr. Asenjo, Santiago, Chile. 5 Department of Neurology, Duke University Medical Center, Durham, NC, USA. 6 Grenoble Institute Neurosciences, Inserm, U1216, CHU Grenoble Alpes, Université Grenoble Alpes, Grenoble, France. 7 Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada. 8 Multimodal Functional Imaging Lab, School of Health, Department of Physics, Concordia University, Montréal, QC, Canada. 9 Montreal Neurological Institute, McGill University, Montréal, QC, Canada. 10 Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada. birgit.frauscher@duke.edu. 11 Department of Biomedical Engineering, Duke Pratt School of Engineering, Durham, NC, USA. birgit.frauscher@duke.edu. 12 Department of Neurology, Duke University Medical Center, Durham, NC, USA. birgit.frauscher@duke.edu. |
||||
Description: |
Stereo-electroencephalography (SEEG) is the gold standard to delineate surgical targets in focal drug-resistant epilepsy. SEEG uses electrodes placed directly into the brain to identify the seizure-onset zone (SOZ). However, its major constraint is limited brain coverage, potentially leading to misidentification of the 'true' SOZ. Here, we propose a framework to assess adequate SEEG sampling by coupling epileptic biomarkers with their spatial distribution and measuring the system's response to a perturbation of this coupling. We demonstrate that the system's response is strongest in well-sampled patients when virtually removing the measured SOZ. We then introduce the spatial perturbation map, a tool that enables qualitative assessment of the implantation coverage. Probability modelling reveals a higher likelihood of well-implanted SOZs in seizure-free patients or non-seizure free patients with incomplete SOZ resections, compared to non-seizure-free patients with complete resections. This highlights the framework's value in sparing patients from unsuccessful surgeries resulting from poor SEEG coverage. |
