Keyword search (4,164 papers available)

"Thaler L" Authored Publications:

Title Authors PubMed ID
1 DNA methylation in people with Anorexia Nervosa: Epigenome-wide patterns in actively ill, long-term remitted, and healthy-eater women Steiger H; Booij L; Thaler L; St-Hilaire A; Israël M; Casey KF; Oliverio S; Crescenzi O; Lee V; Turecki G; Joober R; Szyf M; Breton É; 35703085
PSYCHOLOGY
2 Predictors of non-completion of a day treatment program for adults with eating disorders Thaler L; Booij L; Burnham N; Kenny S; Oliverio S; Israel M; Steiger H; 34971014
PSYCHOLOGY
3 In-person versus virtual therapy in outpatient eating-disorder treatment: A COVID-19 inspired study Steiger H; Booij L; Crescenzi O; Oliverio S; Singer I; Thaler L; St-Hilaire A; Israel M; 34904742
PSYCHOLOGY
4 Plasma levels of one-carbon metabolism nutrients in women with anorexia nervosa Burdo J; Booij L; Kahan E; Thaler L; Israël M; Agellon LB; Nitschmann E; Wykes L; Steiger H; 32427359
PSYCHOLOGY
5 Methylation of the OXTR gene in women with anorexia nervosa: Relationship to social behavior. Thaler L, Brassard S, Booij L, Kahan E, McGregor K, Labbe A, Israel M, Steiger H 31823473
PSYCHOLOGY
6 A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E 30693739
PSYCHOLOGY

 

Title:A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women
Authors:Steiger H,  Booij L,  Kahan `,  McGregor K,  Thaler L,  Fletcher E,  Labbe A,  Joober R,  Israël M,  Szyf M,  Agellon LB,  Gauvin L,  St-Hilaire A,  Rossi E
Link:https://www.ncbi.nlm.nih.gov/pubmed/30693739?dopt=Abstract
Publication:
Keywords:
PMID:30693739 Category:J Psychiatry Neurosci Date Added:2019-06-03
Dept Affiliation: PSYCHOLOGY
1 From the Eating Disorders Program, Douglas University Institute (Steiger, Kahan, Thaler, Fletcher, Israël, St-Hilaire, Rossi); the Research Centre, Douglas University Institute (Steiger, Kahan, Thaler, Fletcher, Joober, Israël, St-Hilaire, Rossi); the Department of Psychiatry, McGill University (Steiger, Booij, Thaler, Joober, Israël, St-Hilaire); the Department of Psychology, Concordia University (Booij); the Sainte-Justine Hospital Research Centre, University of Montreal (Booij); the Department of Epidemiology, Biostatistics, and Occupational Health, McGill University (McGregor); the Department of Decision Sciences, HEC Montreal (Labbe); the Department of Pharmacology and Therapeutics, McGill University (Szyf); the School of Human Nutrition, McGill University (Agellon); and the Centre de recherche du Centre Hospitalier, de l’Université de Montréal (CRCHUM) (Gauvin), Montreal, Que., Canada.

Description:

A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women

J Psychiatry Neurosci. 2019 05 01;44(3):205-213

Authors: Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E

Abstract

Background: This study explored state-related tendencies in DNA methylation in people with anorexia nervosa.

Methods: We measured genome-wide DNA methylation in 75 women with active anorexia nervosa (active), 31 women showing stable remission of anorexia nervosa (remitted) and 41 women with no eating disorder (NED). We also obtained post-intervention methylation data from 52 of the women from the active group.

Results: Comparisons between members of the active and NED groups showed 58 differentially methylated sites (Q < 0.01) that corresponded to genes relevant to metabolic and nutritional status (lipid and glucose metabolism), psychiatric status (serotonin receptor activity) and immune function. Methylation levels in members of the remitted group differed from those in the active group on 265 probes that also involved sites associated with genes for serotonin and insulin activity, glucose metabolism and immunity. Intriguingly, the direction of methylation effects in remitted participants tended to be opposite to those seen in active participants. The chronicity of Illness correlated (usually inversely, at Q < 0.01) with methylation levels at 64 sites that mapped onto genes regulating glutamate and serotonin activity, insulin function and epigenetic age. In contrast, body mass index increases coincided (at Q < 0.05) with generally increased methylation-level changes at 73 probes associated with lipid and glucose metabolism, immune and inflammatory processes, and olfaction.

Limitations: Sample sizes were modest for this type of inquiry, and findings may have been subject to uncontrolled effects of medication and substance use.

Conclusion: Findings point to the possibility of reversible epigenetic alterations in anorexia nervosa, and suggest that an adequate pathophysiological model would likely need to include psychiatric, metabolic and immune components.

PMID: 30693739 [PubMed - in process]




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