Keyword search (4,163 papers available)

"Tam BT" Authored Publications:

Title Authors PubMed ID
1 Combating childhood overweight and obesity: The role of Olympic Movement and bodily movement Tam BT; Wan K; Santosa S; Cai Z; 39991475
SOH
2 Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation Feola S; Al-Nabelsi L; Tam BT; Near J; Morais JA; Santosa S; 39875595
HKAP
3 Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S; 39045668
SOH
4 Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss Murphy J; Tam BT; Kirkland JL; Tchkonia T; Giorgadze N; Pirtskhalava T; Tsoukas MA; Morais JA; Santosa S; 37194560
PERFORM
5 Sex Affects Regional Variations in Subcutaneous Adipose Tissue T Cells but not Macrophages in Adults with Obesity Murphy J; Delaney KZ; Dam V; Tam BT; Khor N; Tsoukas MA; Morais JA; Santosa S; 33179451
PERFORM
6 Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity. Tam BT, Murphy J, Khor N, Morais JA, Santosa S 32808657
PERFORM
7 Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome. Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM 32218464
HKAP
8 Obesity and ageing: Two sides of the same coin. Tam BT, Morais JA, Santosa S 32020741
PERFORM
9 Ghrelin Axis Reveals the Interacting Influence of Central Obesity and Hypertension. Yu AP, Ugwu FN, Tam BT, Lee PH, Lai CW, Wong CSC, Siu PM 30258404
HKAP

 

Title:Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region
Authors:Murphy JDera AMorais JATsoukas MAKhor NSazonova TAlmeida LGCooke ABDaskalopoulou SSTam BTSantosa S
Link:https://pubmed.ncbi.nlm.nih.gov/39045668/
DOI:10.1002/oby.24059
Publication:Obesity (Silver Spring, Md.)
Keywords:
PMID:39045668 Category: Date Added:2024-07-24
Dept Affiliation: SOH
1 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montréal, Québec, Canada.
2 Metabolism, Obesity, and Nutrition Laboratory, School of Health, Concordia University, Montréal, Québec, Canada.
3 Centre de recherche - Axe maladies chroniques, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Ile de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
4 Division of Geriatric Medicine, Department of Medicine, McGill University, McGill University Health Centre (MUHC) - Montréal General Hospital, Montréal, Québec, Canada.
5 Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Royal Victoria Hospital, MUHC Glen Site, Montréal, Québec, Canada.
6 Division of Experimental Medicine, Department of Medicine, McGill University, MUHC Glen Site, Montréal, Québec, Canada.
7 Cardiovascular Health Across the Lifespan (CHAL) Program, Research Institute of the McGill University Health Centre (MUHC), Montréal, Québec, Canada.
8 Division of Internal Medicine, Department of Medicine, McGill University, Royal Victoria Hospital, MUHC Glen Site, Montréal, Québec, Canada.
9 Department of Sport, Physical Education, and Health, Faculty of Social Sciences, Hong Kong Baptist University, Kowloon Tong, China.

Description:

Objective: We aimed to examine the effect of age of obesity onset, sex, and their interaction on abdominal and femoral subcutaneous adipose tissue (SAT) morphology (degree of adipocyte hyperplasia or hypertrophy).

Methods: In this cross-sectional study, we isolated adipocytes via collagenase digestion from abdominal and femoral SAT biopsies taken from male and female adults with childhood-onset obesity (CO; n = 8 males, n = 16 females) or adult-onset obesity (AO; n = 8 males, n = 13 females). Regional body composition was measured with dual-energy x-ray absorptiometry and a single-slice abdominal computed tomography scan. Mean adipocyte size was measured in abdominal and femoral SAT and was used to quantify morphology in android and gynoid subcutaneous fat, respectively.

Results: Abdominal SAT morphology was more hyperplastic in females with CO than females with AO (p = 0.004) but did not differ between males with CO and males with AO (p = 0.996). Conversely, femoral SAT morphology was more hypertrophic in males and females with CO than those with AO.

Conclusions: Age of obesity onset appears to affect SAT morphology differently in the abdominal and femoral regions of male and female adults. Our findings challenge the notion that SAT is uniformly hyperplastic in CO and hypertrophic in AO.





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