Keyword search (4,164 papers available)

"Su Y" Authored Publications:

Title Authors PubMed ID
1 Assessing Port-related Greenhouse Gas Emissions and Mitigation Pathways Through a Comprehensive Framework Applied to the Vancouver Fraser Port Authority Wang Z; Su Y; Lu Z; An C; 41925888
ENCS
2 Spatiotemporal Evolution and Anomaly Assessment of Wildfire-Induced Air Pollution Across Canada Using Satellite AOD Analysis Su Y; Wang Z; Fu H; Yang A; Chen X; An C; 41520990
ENCS
3 Spatio-temporal distribution of AOD and its response to regional energy consumption and air pollution factors in China Su Y; Chen X; Guo J; Yang A; 41308902
ENCS
4 Infants' Social Evaluation of Helpers and Hinderers: A Large-Scale, Multi-Lab, Coordinated Replication Study Lucca K; Yuen F; Wang Y; Alessandroni N; Allison O; Alvarez M; Axelsson EL; Baumer J; Baumgartner HA; Bertels J; Bhavsar M; Byers-Heinlein K; Capelier-Mourguy A; Chijiiwa H; Chin CS; Christner N; Cirelli LK; Corbit J; Daum MM; Doan T; Dresel M; Exner A; Fei W; Forbes SH; Franchin L; Frank MC; Geraci A; Giraud M; Gornik ME; Wiesmann CG; Grossmann T; Hadley IM; Havron N; Henderson AME; Matzner EH; Immel BA; Jankiewicz G; Jedryczka W; Kanakogi Y; Kominsky JF; Lew-Williams C; Liberman Z; Liu L; Liu Y; Loeffler MT; Martin A; Mayor J; Meng X; Misiak M; Moreau D; Nencheva ML; Oña LS; Otálora Y; Paulus M; Pepe B; Pickron CB; Powell LJ; Proft M; Quinn AA; Rakoczy H; Reschke PJ; Roth-Hanania R; Rothmaler K; Schlegelmilch K; Schlingloff-Nemecz L; Schmuckler MA; Schuwerk T; Seehagen S; Sen HH; Shainy MR; Silvestri V; Soderstrom M; Sommerville J; Song HJ; Sorokowski P; Stutz SE; Su Y; Taborda-Osorio H; Tan AWM; Tatone D; Taylor-Partridge T; Tsang CKA; Urbanek A; Uzefovsky F; Visser I; Wertz AE; Williams M; Wolsey K; Wong TT; Woodward AM; Wu Y; Zeng Z; Zimmer L; Hamlin JK; 39600132
PSYCHOLOGY
5 Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η. O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ 27574558
CHEMBIOCHEM

 

Title:Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η.
Authors:O'Flaherty DKPatra ASu YGuengerich FPEgli MWilds CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/27574558?dopt=Abstract
Publication:
Keywords:
PMID:27574558 Category:Chem Sci Date Added:2019-05-31
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec H4B1R6, Canada.
2 Department of Biochemistry, Vanderbilt Institute of Chemical Biology, and Center for Structural Biology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States.

Description:

Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase ?.

Chem Sci. 2016 Aug 01;7(8):4896-4904

Authors: O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ

Abstract

DNA lesions that elude repair may undergo translesion synthesis catalyzed by Y-family DNA polymerases. O4-Alkylthymidines, persistent adducts that can result from carcinogenic agents, may be encountered by DNA polymerases. The influence of lesion orientation around the C4-O4 bond on processing by human DNA polymerase ? (hPol ?) was studied for oligonucleotides containing O4-methylthymidine, O4-ethylthymidine, and analogs restricting the O4-methylene group in an anti-orientation. Primer extension assays revealed that the O4-alkyl orientation influences hPol ? bypass. Crystal structures of hPol ?•DNA•dNTP ternary complexes with O4-methyl- or O4-ethylthymidine in the template strand showed the nucleobase of the former lodged near the ceiling of the active site, with the syn-O4-methyl group engaged in extensive hydrophobic interactions. This unique arrangement for O4-methylthymidine with hPol ?, inaccessible for the other analogs due to steric/conformational restriction, is consistent with differences observed for nucleotide incorporation and supports the concept that lesion conformation influences extension across DNA damage. Together, these results provide mechanistic insights on the mutagenicity of O4MedT and O4EtdT when acted upon by hPol ?.

PMID: 27574558 [PubMed - as supplied by publisher]





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