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PubMed Publications| Keyword search (4,163 papers available) |  |
"Sigal RJ" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity | Goldfield GS; Cameron JD; Sigal RJ; Kenny GP; Prud' homme D; Ngu M; Alberga AS; Doucette S; Goldfield DB; Tulloch H; Thai H; Simas KR; Walsh J; | 38997217 HKAP |
| 2 | Effects of the HEARTY exercise randomized controlled trial on eating behaviors in adolescents with obesity | Alberga AS; Edache IY; Sigal RJ; von Ranson KM; Russell-Mayhew S; Kenny GP; Doucette S; Prud' homme D; Hadjiyannakis S; Cameron JD; Goldfield GS; | 37034563 HKAP |
| 3 | Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study | Goldfield GS; Walsh J; Sigal RJ; Kenny GP; Hadjiyannakis S; De Lisio M; Ngu M; Prud' homme D; Alberga AS; Doucette S; Goldfield DB; Cameron JD; | 34867148 IMAGING |
| 4 | Understanding low adherence to an exercise program for adolescents with obesity: the HEARTY trial. | Alberga AS, Sigal RJ, Sweet SN, Doucette S, Russell-Mayhew S, Tulloch H, Kenny GP, Prud'homme D, Hadjiyannakis S, Goldfield GS | 31687168 HKAP |
| 5 | Edmonton Obesity Staging System for Pediatrics, quality of life and fitness in adolescents with obesity. | Kakon GA, Hadjiyannakis S, Sigal RJ, Doucette S, Goldfield GS, Kenny GP, Prud'homme D, Buchholz A, Lamb M, Alberga AS | 31687169 HKAP |
| 6 | Corrigendum to "Effects of aerobic training, resistance training, or both on brain-derived neurotrophic factor in adolescents with obesity: The hearty randomized controlled trial" Physiology & Behavior, Volume 191, 1 July 2018, Pages 138-145. | Goldfield GS, Kenny GP, Prud'homme D, Holcik M, Alberga AS, Fahnestock M, Cameron JD, Doucette S, Hadjiyannakis S, Tulloch H, Tremblay MS, Walsh J, Guerin E, Gunnell KE, D'Angiulli A, Sigal RJ | 30428994 PSYCHOLOGY |
| 7 | Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial. | Walsh JJ, D'Angiulli A, Cameron JD, Sigal RJ, Kenny GP, Holcik M, Doucette S, Alberga AS, Prud'homme D, Hadjiyannakis S, Gunnell K, Goldfield GS | 30363954 HKAP |
| 8 | Interindividual variability and individual responses to exercise training in adolescents with obesity. | Walsh JJ, Bonafiglia JT, Goldfield GS, Sigal RJ, Kenny GP, Doucette S, Hadjiyannakis S, Alberga AS, Prud'homme D, Gurd BJ | 31121100 HKAP |
| Title: | The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity | ||||
| Authors: | Goldfield GS, Cameron JD, Sigal RJ, Kenny GP, Prud', homme D, Ngu M, Alberga AS, Doucette S, Goldfield DB, Tulloch H, Thai H, Simas KR, Walsh J | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/38997217/ | ||||
| DOI: | 10.14814/phy2.16140 | ||||
| Publication: | Physiological reports | ||||
| Keywords: | brain derived‐; neurotrophic factor (BDNF); health‐; related quality of life (HRQoL); obesity; polymorphism; youth; | ||||
| PMID: | 38997217 | Category: | Date Added: | 2024-07-13 | |
| Dept Affiliation: |
HKAP
1 Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada. 2 Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada. 3 School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada. 4 Department of Psychology, Carleton University, Ottawa, Ontario, Canada. 5 Department of Pharmacy, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. 6 Department of Medicine, Cardiac Sciences and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. 7 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada. 8 University of Moncton, Moncton, New Brunswick, Canada. 9 Department of Exercise Science, Concordia University, Montreal, Quebec, Canada. 10 Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada. 11 Life Sciences, Queen's University, Kingston, Ontario, Canada. 12 Division of Cardiac Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. 13 Department of Psychology, McGill University, Montreal, Quebec, Canada. 14 Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada. 15 Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. |
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Description: |
The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-related quality of life (HRQoL) remains unknown. This study examined, in youth with obesity, whether carriers of the BDNF Val66met polymorphism Met-alleles (A/A or G/A) differed from noncarriers (G/G) on HRQoL. The participants were 187 adolescents with obesity. Ninety-nine youth were carriers of the homozygous Val/Val (G/G) alleles, and 88 were carriers of the Val/Met (G/A) or Met/Met (A/A) alleles. Blood samples were drawn in the morning after an overnight fast for genotyping. HRQoL was measured using the Pediatric-Quality of Life core version. Compared to carriers of the Val66Met Val (G/G) alleles, carriers of the Met-Alleles reported significantly higher physical -HRQoL (p = 0.02), school-related HRQoL, (p = 0.05), social-related HRQoL (p = 0.05), and total HRQoL (p = 0.03), and a trend for Psychosocial-HRQoL. Research is needed to confirm our findings and determine whether carriers of the BDNF Val66Met homozygous Val (G/G) alleles may be at risk of diminished HRQoL, information that can influence interventions in a high-risk population of inactive youth with obesity. |
