Keyword search (4,163 papers available)

"Rutherford S" Authored Publications:

Title Authors PubMed ID
1 Stress-induced changes in the expression of the clock protein PERIOD1 in the rat limbic forebrain and hypothalamus: role of stress type, time of day, and predictability. Al-Safadi S, Al-Safadi A, Branchaud M, Rutherford S, Dayanandan A, Robinson B, Amir S 25338089
CSBN
2 Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain. Al-Safadi S, Branchaud M, Rutherford S, Amir S 26075608
CSBN
3 Exploring the role of locomotor sensitization in the circadian food entrainment pathway. Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S 28301599
PSYCHOLOGY

 

Title:Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain.
Authors:Al-Safadi S,  Branchaud M,  Rutherford S,  Amir S
Link:https://www.ncbi.nlm.nih.gov/pubmed/26075608?dopt=Abstract
Publication:
Keywords:
PMID:26075608 Category:PLoS One Date Added:2019-05-31
Dept Affiliation: CSBN
1 Department of Biology, Concordia University, SP-375.07, 7141 Sherbrooke Street West, Montréal, Quebéc, H4B 1R6, Canada; Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, SP-244, 7141 Sherbrooke Street West, Montréal, Quebéc, H4B 1R6, Canada.
2 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, SP-244, 7141 Sherbrooke Street West, Montréal, Quebéc, H4B 1R6, Canada.

Description:

Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain.

PLoS One. 2015;10(6):e0130085

Authors: Al-Safadi S, Branchaud M, Rutherford S, Amir S

Abstract

The secretion of glucocorticoids in mammals is under circadian control, but glucocorticoids themselves are also implicated in modulating circadian clock gene expression. We have shown that the expression of the circadian clock protein PER1 in the forebrain is modulated by stress, and that this effect is associated with changes in plasma corticosterone levels, suggesting a possible role for glucocorticoids in the mediation of stress-induced changes in the expression of PER1 in the brain. To study this, we assessed the effects of adrenalectomy and of pretreatment with the glucocorticoid receptor antagonist, mifepristone, on the expression of PER1 in select limbic and hypothalamic regions following acute exposure to a neurogenic stressor, restraint, or a systemic stressor, 2-Deoxy-D-glucose (2DG) in rats. Acute restraint suppressed PER1 expression in the oval nucleus of the bed nucleus of the stria terminalis (BNSTov) and the central nucleus of the amygdala (CEAl), whereas 2DG increased PER1 in both regions. Both stressors increased PER1 expression in the paraventricular (PVN) and dorsomedial (DMH) nuclei of the hypothalamus, and the piriform cortex (Pi). Adrenalectomy and pretreatment with mifepristone reversed the effects of both stressors on PER1 expression in the BNSTov and CEAl, and blocked their effects in the DMH. In contrast, both treatments enhanced the effects of restraint and 2DG on PER1 levels in the PVN. Stress-induced PER1 expression in the Pi was unaffected by either treatment. PER1 expression in the suprachiasmatic nucleus, the master circadian clock, was not altered by either exposure to stress or by the glucocorticoid manipulations. Together, the results demonstrate a key role for glucocorticoid signaling in stress-induced changes in PER1 expression in the brain.

PMID: 26075608 [PubMed - indexed for MEDLINE]




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