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PubMed Publications| Keyword search (4,163 papers available) |  |
"Royer J" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | How vigilance states influence source imaging of physiological brain oscillations: evidence from intracranial EEG | Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B; | 41687693 SOH |
| 2 | Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy | Xie K; Sahlas E; Ngo A; Chen J; Arafat T; Royer J; Zhou Y; Rodríguez-Cruces R; Dascal A; Caldairou B; Fadaie F; Barnett A; Audrain S; Larivière S; Caciagli L; Pana R; Weil AG; Grova C; Frauscher B; Schrader DV; Zhang Z; Concha L; Bernasconi A; Bernasconi N; Bernhardt BC; | 41258102 SOH |
| 3 | Targeted density electrode placement achieves high concordance with traditional high-density EEG for electrical source imaging in epilepsy | Horrillo-Maysonnial A; Avigdor T; Abdallah C; Mansilla D; Thomas J; von Ellenrieder N; Royer J; Bernhardt B; Grova C; Gotman J; Frauscher B; | 37704552 PERFORM |
| 4 | The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging | Paquola C; Royer J; Lewis LB; Lepage C; Glatard T; Wagstyl K; DeKraker J; Toussaint PJ; Valk SL; Collins DL; Khan A; Amunts K; Evans AC; Dickscheid T; Bernhardt BC; | 34431476 IMAGING |
| Title: | Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy | ||||
| Authors: | Xie K, Sahlas E, Ngo A, Chen J, Arafat T, Royer J, Zhou Y, Rodríguez-Cruces R, Dascal A, Caldairou B, Fadaie F, Barnett A, Audrain S, Larivière S, Caciagli L, Pana R, Weil AG, Grova C, Frauscher B, Schrader DV, Zhang Z, Concha L, Bernasconi A, Bernasconi N, Bernhardt BC | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41258102/ | ||||
| DOI: | 10.1038/s41467-025-65042-1 | ||||
| Publication: | Nature communications | ||||
| Keywords: | |||||
| PMID: | 41258102 | Category: | Date Added: | 2025-11-19 | |
| Dept Affiliation: |
SOH
1 McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. ke.xie@mail.mcgill.ca. 2 McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. 3 Sherbrooke Laboratory for Integrative Connectomics, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC, Canada. 4 Department of Neurology, Inselspital, Sleep-Wake-Epilepsy-Center, Bern University Hospital, University of Bern, Bern, Switzerland. 5 Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. 6 Division of Neurosurgery, Department of Surgery, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. 7 Multimodal Functional Imaging Lab, Department of Physics and Concordia School of Health, Concordia University, Montreal, QC, Canada. 8 Multimodal Functional Imaging Lab, Department of Biomedical Engineering, McGill University, Montreal, QC, Canada. 9 Department of Neurology, Department of Biomedical Engineering, Duke University, Durham, NC, USA. 10 British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada. 11 Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China. 12 Institute of Neurobiology, Universidad Nacional Autónoma de Mexico, Queretaro, Mexico. 13 McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. boris.bernhardt@mcgill.ca. |
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Description: |
Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE patients, 298 healthy controls, and 45 disease controls. Patient-specific deviations from typical lifespan trajectories of intrinsic brain function were mapped using normative modeling. Regional functional alterations were heterogeneous but overlapped most in the mesiotemporal cortex. Connectome-based simulations revealed abnormality spread followed structural network architecture, highlighting the hippocampus as well as paralimbic and medial default-mode regions as epicenters. Multimodal integration implicated superficial white-matter microstructural alterations as a key contributor. Supervised models achieved AUCs of 0.77 for distinguishing TLE from disease controls, 0.74 for lateralizing seizure focus, and 0.64 for predicting postsurgical seizure freedom; greater contralateral temporal deviations predicted poorer outcomes. These findings support individualized functional biomarkers for precision presurgical care in focal epilepsy. |
