Keyword search (4,164 papers available)

"Ragert P" Authored Publications:

Title Authors PubMed ID
1 TDCS effects on pointing task learning in young and old adults. Kaminski E, Engelhardt M, Hoff M, Steele C, A Villringer, Ragert P 33564052
HKAP
2 Investigation of the confounding effects of vasculature and metabolism on computational anatomy studies. Tardif CL, Steele CJ, Lampe L, Bazin PL, Ragert P, Villringer A, Gauthier CJ 28159689
PERFORM

 

Title:Investigation of the confounding effects of vasculature and metabolism on computational anatomy studies.
Authors:Tardif CL,  Steele CJ,  Lampe L,  Bazin PL,  Ragert P,  Villringer A,  Gauthier CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/28159689?dopt=Abstract
DOI:10.1016/j.neuroimage.2017.01.025
Publication:NeuroImage
Keywords:Blood volume;  Computational anatomy;  Cortical thickness;  Grey matter volume;  Metabolic bias;  Vascular bias; 
PMID:28159689 Category:Neuroimage Date Added:2019-04-15
Dept Affiliation: PERFORM
1 Douglas Mental Health University Institute, McGill University, Montreal, Canada.
2 Douglas Mental Health University Institute, McGill University, Montreal, Canada; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
3 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
4 University of Leipzig, Department of Sport Science, Leipzig, Germany.
5 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Cognitive Neurology, University Hospital, Leipzig, Germany; Mind & Brain Institute, Berlin School of Mind and Brain, Charité and Humboldt-University, Berlin, Germany.
6 Concordia University, Department of Physics, PERFORM Centre, Montreal, Canada. Electronic address: claudine.gauthier@concordia.ca.

Description:

Investigation of the confounding effects of vasculature and metabolism on computational anatomy studies.

Neuroimage. 2017 04 01;149:233-243

Authors: Tardif CL, Steele CJ, Lampe L, Bazin PL, Ragert P, Villringer A, Gauthier CJ

Abstract

Computational anatomy studies typically use T1-weighted magnetic resonance imaging contrast to look at local differences in cortical thickness or grey matter volume across time or subjects. This type of analysis is a powerful and non-invasive tool to probe anatomical changes associated with neurodevelopment, aging, disease or experience-induced plasticity. However, these comparisons could suffer from biases arising from vascular and metabolic subject- or time-dependent differences. Differences in blood flow and volume could be caused by vasodilation or differences in vascular density, and result in a larger signal contribution of the blood compartment within grey matter voxels. Metabolic changes could lead to differences in dissolved oxygen in brain tissue, leading to T1 shortening. Here, we analyze T1 maps and T1-weighted images acquired during different breathing conditions (ambient air, hypercapnia (increased CO2) and hyperoxia (increased O2)) to evaluate the effect size that can be expected from changes in blood flow, volume and dissolved O2 concentration in computational anatomy studies. Results show that increased blood volume from vasodilation during hypercapnia is associated with an overestimation of cortical thickness (1.85%) and grey matter volume (3.32%), and that both changes in O2 concentration and blood volume lead to changes in the T1 value of tissue. These results should be taken into consideration when interpreting existing morphometry studies and in future study design. Furthermore, this study highlights the overlap in structural and physiological MRI, which are conventionally interpreted as two independent modalities.

PMID: 28159689 [PubMed - indexed for MEDLINE]




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