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PubMed Publications| Keyword search (4,163 papers available) |  |
"Pereira V" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database | Greco BM; Zapata G; Dandage R; Papkov M; Pereira V; Lefebvre F; Bourque G; Parts L; Kuzmin E; | 40580499 BIOLOGY |
| 2 | Single-cell imaging of protein dynamics of paralogs reveals sources of gene retention | Dandage R; Papkov M; Greco BM; Pereira V; Fishman D; Friesen H; Wang K; Styles EB; Kraus O; Grys B; Zapata G; Lefebvre F; Bourque G; Boone C; Andrews BJ; Parts L; Kuzmin E; | 40585364 BIOLOGY |
| 3 | Trans-regulatory variant network contributes to missing heritability | Pereira V; Kuzmin E; | 38216282 BIOLOGY |
| Title: | Single-cell imaging of protein dynamics of paralogs reveals sources of gene retention | ||||
| Authors: | Dandage R, Papkov M, Greco BM, Pereira V, Fishman D, Friesen H, Wang K, Styles EB, Kraus O, Grys B, Zapata G, Lefebvre F, Bourque G, Boone C, Andrews BJ, Parts L, Kuzmin E | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40585364/ | ||||
| DOI: | 10.1016/j.isci.2025.112771 | ||||
| Publication: | iScience | ||||
| Keywords: | Functional aspects of cell biology; Molecular biology; Phylogenetics; | ||||
| PMID: | 40585364 | Category: | Date Added: | 2025-07-01 | |
| Dept Affiliation: |
BIOLOGY
1 Department of Biology, Concordia University, Montreal, QC, Canada. 2 Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, QC, Canada. 3 Institute of Computer Science, University of Tartu, Tartu, Estonia. 4 The Donnelly Centre, University of Toronto, Toronto, ON, Canada. 5 Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. 6 Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada. 7 Canadian Centre for Computational Genomics (C3G), McGill University, Montreal, QC, Canada. 8 Victor Phillip Dahdaleh Institute of Genomic Medicine, Montreal, QC, Canada. 9 Department of Human Genetics, McGill University, Montreal, QC, Canada. 10 Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. 11 Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada. |
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Description: |
Gene duplication is common across the Tree of Life and contributes to genomic robustness. In this study, we examined changes in the subcellular localization and abundance of proteins in response to the deletion of their paralogs originating from the whole-genome duplication event, which is a largely unexplored mechanism of functional divergence. We performed a systematic single-cell imaging analysis of protein dynamics and screened subcellular redistribution of proteins. We find that 20% of proteins exhibit redistribution, of which 1/3 relocalized and 1/2 changed in abundance. Paralogs showed dependency, whereby proteins required their paralog to maintain their endogenous abundance or localization, 2-fold more often than compensation. Network feature analysis suggested the importance of functional redundancy and rewiring of protein and genetic interactions underlying redistribution paralog response. Translation of alternate protein isoform emerged as a compensatory mechanism. This study provides insight into paralog retention and evolutionary forces that shape genomes. |
