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PubMed Publications| Keyword search (4,163 papers available) |  |
"Ouellet-Morin I" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Correction: Polygenic scores of obesity in childhood based on summary statistics from adults versus children | Goulet D; Boivin M; Gravel C; Little J; Ouellet-Morin I; Gouin J; Dubois L; | 41182116 CONCORDIA |
| 2 | Polygenic scores of obesity in childhood based on summary statistics from adults vs. children | Goulet D; Boivin M; Gravel C; Little J; Ouellet-Morin I; Gouin JP; Dubois L; | 40132211 CONCORDIA |
| 3 | Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences | Bouliane M; Boivin M; Kretschmer T; Lafreniere B; Paquin S; Tremblay R; Côté S; Gouin JP; Andlauer TFM; Petitclerc A; Ouellet-Morin I; | 39907790 PSYCHOLOGY |
| 4 | Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort | Scardera S; Geoffroy MC; Langevin R; Perret LC; Collin-Vézina D; Voronin I; Gouin JP; Meng X; Boivin M; Ouellet-Morin I; | 39465601 PSYCHOLOGY |
| 5 | Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis | Mascheretti S; Forni D; Lampis V; Fumagalli L; Paquin S; Andlauer TFM; Wang W; Dionne G; Brendgen MR; Vitaro F; Ouellet-Morin I; Rouleau G; Gouin JP; Côté S; Tremblay RE; Turecki G; Garon-Carrier G; Boivin M; Battaglia M; | 37146008 PSYCHOLOGY |
| 6 | The effects of walking in nature on negative and positive affect in adult psychiatric outpatients with major depressive disorder: A randomized-controlled study | Watkins-Martin K; Bolani D; Richard-Devantoy S; Pennestri MH; Malboeuf-Hurtubise C; Philippe F; Guindon J; Gouin JP; Ouellet-Morin I; Geoffroy MC; | 36058362 PSYCHOLOGY |
| 7 | Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort | Watkins-Martin K; Orri M; Pennestri MH; Castellanos-Ryan N; Larose S; Gouin JP; Ouellet-Morin I; Chadi N; Philippe F; Boivin M; Tremblay RE; Côté S; Geoffroy MC; | 34496901 PSYCHOLOGY |
| 8 | Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood | Morneau-Vaillancourt G; Andlauer TFM; Ouellet-Morin I; Paquin S; Brendgen MR; Vitaro F; Gouin JP; Séguin JR; Gagnon É; Cheesman R; Forget-Dubois N; Rouleau GA; Turecki G; Tremblay RE; Côté SM; Dionne G; Boivin M; | 34085288 PSYCHOLOGY |
| Title: | Polygenic scores of obesity in childhood based on summary statistics from adults vs. children | ||||
| Authors: | Goulet D, Boivin M, Gravel C, Little J, Ouellet-Morin I, Gouin JP, Dubois L | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/40132211/ | ||||
| DOI: | 10.1139/cjpp-2024-0221 | ||||
| Publication: | Canadian journal of physiology and pharmacology | ||||
| Keywords: | |||||
| PMID: | 40132211 | Category: | Date Added: | 2025-03-25 | |
| Dept Affiliation: |
CONCORDIA
1 University of Ottawa, Ottawa, Ontario, Canada; dgoul082@uottawa.ca. 2 Université Laval, Quebec City, Canada; michel.boivin@psy.ulaval.ca. 3 University of Ottawa, Ottawa, Canada. 4 McGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montreal, Canada. 5 University of Ottawa, Department of Mathematics and Statistics, Ottawa, Canada; cgravel@uottawa.ca. 6 University of Ottawa, Epidemiology & Community Medicine, Ottawa, Ontario, Canada. 7 Canada Research Chair in Human Genome Epidemiology, Ottawa, Ontario, Canada; jlittle@uottawa.ca. 8 Université de Montréal, Montreal, Canada; isabelle.ouellet-morin@umontreal.ca. 9 Université Concordia, Département de psychologie, Montreal, Canada; JP.Gouin@concordia.ca. 10 University of Ottawa, Ottawa, Canada; ldubois@uottawa.ca. |
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Description: |
The lack of polygenic scores (PGSs) developed for body-mass index (BMI) in children may be problematic because the genetic architecture characterizing BMI changes throughout life. This study aims to describe the genetic susceptibility to obesity in children and to compare two PGSs based on data from adults and children and their association with BMI and discrimination of obesity. The study sample comprises 717 participants aged 4 to 13. Adult- and child-based PGS were evaluated by examining 1) mean BMI across polygenic score risk categories, 2) the capacity to identify obesity with logistic regression and 3) the linear association with BMI z-scores using linear regression. Increases in one standardized unit of adult-based PGS were related to a stronger increase in BMI z-score (ß=0.24-0.39) than PGS derived in children (ß=0.21-0.30). The association between obesity and the child score was higher (OR = 1.75-2.33) than for the adult score (OR = 1.74-2.06) for the age group 4-7 years. The inverse was observed for the age group 8-13 years (ORchild 1.56-1.79 vs. ORadult 1.78-2.54). Both adult- and child-based PGS show strong associations with BMI and risk of obesity, with the adult-based score standing out from 8 years old. |
