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PubMed Publications| Keyword search (4,164 papers available) |  |
"Nikzad S" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The effect of Wharton's jelly-derived stem cells seeded/boron-loaded acellular scaffolds on the healing of full-thickness burn wounds in the rat model | Nikzad S; Same S; Safiri S; Dolati S; Roushangar Zineh B; Meshgi S; Roshangar L; Sahin F; | 38364284 BIOLOGY |
| 2 | 17β-Estradiol-Loaded Exosomes for Targeted Drug Delivery in Osteoporosis: A Comparative Study of Two Loading Methods | Gholami Farashah MS; Javadi M; Soleimani Rad J; Shakouri SK; Asnaashari S; Dastmalchi S; Nikzad S; Roshangar L; | 38022800 BIOLOGY |
| 3 | Alleviative Effects of Adipose Tissue-derived Stem Cells and α-NETA on Metabolic, Biochemical, and Endocrine Parameters in a Letrozole-induced Rat Model of PCOS | Nejabati HR; Nikzad S; Roshangar L; | 37584355 BIOLOGY |
| 4 | Kaempferol: A Dietary Flavonol in Alleviating Obesity | Nejabati HR; Nikzad S; Roshangar L; | 37537778 BIOLOGY |
| 5 | Therapeutic Potential of Mesenchymal Stem Cells in PCOS | Nejabati HR; Nikzad S; Roshangar L; | 37198984 BIOLOGY |
| Title: | Therapeutic Potential of Mesenchymal Stem Cells in PCOS | ||||
| Authors: | Nejabati HR, Nikzad S, Roshangar L | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/37198984/ | ||||
| DOI: | 10.2174/1574888X18666230517123256 | ||||
| Publication: | Current stem cell research & therapy | ||||
| Keywords: | Polycystic ovary syndrome; exosomes; mesenchymal stem cells; ovarian reserve; reproduction; secretome; | ||||
| PMID: | 37198984 | Category: | Date Added: | 2023-05-18 | |
| Dept Affiliation: | BIOLOGY | ||||
Description: |
Polycystic ovary syndrome (PCOS) is a major reproductive endocrine disorder affecting different facets of a woman's life, comprising reproduction, metabolism, and mental health. Recently, several research groups have brought attention to the therapeutic capacity of mesenchymal stem cells (MSCs) for the treatment of female reproductive disorders. It is highlighted that the treatment with bone marrow mesenchymal stem cells (BMMSCs) considerably diminishes the levels of some inflammatory markers as well as essential genes for ovarian production of androgens, which are considerably higher in theca cells of PCOS women than in those of healthy cases. In addition, studies show that BMMSCs improve in vitro maturation (IVM) of germinal vesicles (GVs) and the number of antral follicles while lessening the number of primary and preantral follicles in mice with PCOS compared to healthy controls. Regarding adipose-derived mesenchymal stem cells (AdMSCs), these cells restore the ovarian structure, enhance the number of oocytes and corpora luteum, and diminish the number of aberrant cystic follicles in PCOS rats. Some research also indicates that umbilical cord mesenchymal stem cells (UC-MSCs) alleviate the inflammation of granulosa cells in women with PCOS. Therefore, due to the limited research on MSC therapy in PCOS, in this review, we summarize the current knowledge on the therapeutic potential of three types of MSCs: BMMSCs, AdMSCs, UC-MSCs and their secretome in the treatment of PCOS. |
