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Cycles of freeze-thaw (FT) are among the key landscape processes in cold regions. Under current global warming, understanding the alterations in FT characteristics is of a great importance for advising land management strategies in northern latitudes. Using a generic statistical approach, we address the impacts of compound changes in air temperature and snow depth on FT responses across Québec, a Canadian province ~ 2.5 times larger than France. Our findings show significant and complex responses of landscape FT to compound changes in temperature and snow depth. We note a vivid spatial divide between northern and southern regions and point to the asymmetric and nonlinear nature of the FT response. In general, the response of FT characteristics is amplified under compound warming compared to cooling conditions. In addition, FT responses include nonlinearity, meaning that compounding changes in temperature and snow depth have more severe impacts compared to the cumulative response of each individually. These asymmetric and nonlinear responses have important implications for the future environment and socio-economic management in a thawing Québec and highlight the complexity of landscape responses to climatic changes in cold regions.