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PubMed Publications| Keyword search (4,163 papers available) |  |
"Liu-Ambrose T" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment | Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T; | 41929984 HKAP |
| 2 | Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial | Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC; | 41795685 HKAP |
| 3 | The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial | Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH; | 41694460 SOH |
| 4 | Intra-individual variability in cognitive performance predicts falls in older adults with chronic stroke | Dimri V; Davis JC; Boa Sorte Silva NC; Balbim GM; Eng JJ; Liu-Ambrose T; | 41474479 HKAP |
| 5 | Dementia Care Research and Psychosocial Factors | Mancor E; Montero-Odasso M; Bherer L; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Li K; | 41448628 CONCORDIA |
| 6 | Clinical Manifestations | Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L; | 41447475 CONCORDIA |
| 7 | Developing Topics | Silva NCBS; Stein RG; Gu Y; Hsu CL; Tam RC; Salluzzi M; McCreary CR; Alkeridy WA; Lam K; MacKay AL; Kolind S; Cossette B; Griffith LE; Hogan DB; McMillan JM; Raina P; Smith EE; Liu-Ambrose T; | 41434542 CONCORDIA |
| 8 | Public Health | Silva NCBS; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy WA; Kramer AF; Liu-Ambrose T; | 41435075 CONCORDIA |
| 9 | Public Health | Pieruccini-Faria F; Son S; Liu-Ambrose T; Burhan AM; Almeida QJ; Middleton LE; Li K; Fraser S; Bherer L; Montero-Odasso M; | 41435121 CONCORDIA |
| 10 | Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial | Pieruccini-Faria F; Son S; Zou G; Almeida QJ; Middleton LE; Bray NW; Lussier M; Shoemaker JK; Speechley M; Liu-Ambrose T; Burhan AM; Camicioli R; Li KZH; Fraser S; Berryman N; Bherer L; Montero-Odasso M; | 40966614 SOH |
| 11 | 24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment | Balbim GM; Boa Sorte Silva NC; Falck RS; Kramer AF; Voss MW; Liu-Ambrose T; | 40693459 HKAP |
| 12 | Physical activity may protect myelin via modulation of high-density lipoprotein | Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T; | 39989020 HKAP |
| 13 | Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial | Montero-Odasso M; Zou G; Speechley M; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li KZH; Fraser S; Pieruccini-Faria F; Berryman N; Lussier M; Shoemaker JK; Son S; Bherer L; | 37471089 PERFORM |
| 14 | Guidelines for Gait Assessments in the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Cullen S, Montero-Odasso M, Bherer L, Almeida Q, Fraser S, Muir-Hunter S, Li K, Liu-Ambrose T, McGibbon CA, McIlroy W, Middleton LE, Sarquis-Adamson Y, Beauchet O, McFadyen BJ, Morais JA, Camicioli R, Canadian Gait and Cognition Network | 29977431 ENCS |
| 15 | SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment. | Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini-Faria F, Shoemaker K, Speechley M, Vasudev A, Zou GY, Berryman N, Lussier M, Vanderhaeghe L, Bherer L | 29661156 PERFORM |
| 16 | Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J, Canadian Gait and Cognition Network | 30101279 PERFORM |
| 17 | Brain gray matter volume associations with gait speed and related structural covariance networks in cognitively healthy individuals and in patients with mild cognitive impairment: A cross-sectional study. | Beauchet O, Montembeault M, Barden JM, Szturm T, Bherer L, Liu-Ambrose T, Chester VL, Li K, Helbostad JL, Allali G, Canadian Gait Consortium | 31075383 PSYCHOLOGY |
| 18 | A review of the effects of physical activity and exercise on cognitive and brain functions in older adults. | Bherer L, Erickson KI, Liu-Ambrose T | 24102028 PERFORM |
| 19 | Physical exercise and brain functions in older adults. | Bherer L, Erickson KI, Liu-Ambrose T | 24163767 PERFORM |
| 20 | Anti-Dementia Drugs, Gait Performance and Mental Imagery of Gait: A Non-Randomized Open-Label Trial. | Beauchet O, Barden J, Liu-Ambrose T, Chester VL, Annweiler C, Szturm T, Grenier S, Léonard G, Bherer L, Allali G, Canadian Gait Consortium | 27568453 PERFORM |
| 21 | Association Between Falls and Brain Subvolumes: Results from a Cross-Sectional Analysis in Healthy Older Adults. | Beauchet O, Launay CP, Barden J, Liu-Ambrose T, Chester VL, Szturm T, Grenier S, Léonard G, Bherer L, Annweiler C, Helbostad JL, Verghese J, Allali G, Biomathics and Canadian Gait Consortium | 27785698 PERFORM |
| Title: | Public Health | ||||
| Authors: | Pieruccini-Faria F, Son S, Liu-Ambrose T, Burhan AM, Almeida QJ, Middleton LE, Li K, Fraser S, Bherer L, Montero-Odasso M | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/41435121/ | ||||
| DOI: | 10.1002/alz70860_103664 | ||||
| Publication: | Alzheimer s & dementia : the journal of the Alzheimer s Association | ||||
| Keywords: | |||||
| PMID: | 41435121 | Category: | Date Added: | 2025-12-23 | |
| Dept Affiliation: |
CONCORDIA
1 Gait and Brain Laboratory, Parkwood Institute, London, ON, Canada. 2 Gait & Brain Lab; Lawson Research Institute; Schulich School of Medicine& Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada. 3 Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. 4 Parkwood Institute, London, ON, Canada. 5 Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 6 Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. 7 University of British Columbia, Vancouver, BC, Canada. 8 Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. 9 University of Toronto, Toronto, ON, Canada. 10 Care Space Health, Waterloo, ON, Canada. 11 Schlegel-UW Research Institute for Aging, Waterloo, ON, Canada. 12 University of Waterloo, Waterloo, ON, Canada. 13 Concordia University, Montreal, QC, Canada. 14 University of Ottawa, Ottawa, ON, Canada. 15 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. 16 University of Montreal, Montreal, QC, Canada. 17 Schulich School of Medicine & Dentistry, Division of Geriatric Medicine, Western University, London, ON, Canada. |
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Description: |
Background: Mild Cognitive Impairment (MCI) may be associated with the presence of the apolipoprotein E4 allele (APOE4), a genetic factor linked to accelerated cognitive decline. The SYNERGIC trial demonstrated that physical exercise (PE) involving aerobic and resistance training improves global cognition in individuals with MCI, with significantly enhanced benefits of cognitive training but not vitamin D. The role of APOE4 status in responsiveness to these interventions remains unclear. Method: Of 175 participants in the SYNERGIC trial, 80 underwent APOE4 genotyping. This study analyzed 67 participants (mean age: 73.8 years; 43.2% women) who completed a 6-month multidomain intervention across four arms: (1) PE + Cognitive training (Neuropeak®) + Vitamin D; (2) PE + Cognitive training; (3) PE + Vitamin D; and (4) PE alone. Changes in global cognition (ADAS-Cog-13) were compared between APOE4-positive and APOE4-negative individuals using ANOVA. Result: APOE4-positive participants showed attenuated global cognitive improvements from multidomain interventions compared to APOE4-negative participants (mean difference = -2.08, 95% CI: -4.18 to 0.11; p = 0.052; d = -0.56). A significant group effect (p = 0.03) revealed that the PE + Vitamin D arm worsened global cognition over time compared to all other arms, with significant decline relative to the arm receiving all three interventions (p = 0.02). Sensitivity analysis excluding arms with vitamin D confirmed the attenuated effect of APOE4-positive status on global cognition (mean difference = -2.99, 95% CI: -6.10 to 0.11; p = 0.05; d = -0.78). Conclusion: Individuals with MCI and APOE4-positive status exhibit reduced responsiveness to multidomain interventions for global cognition, likely due to underlying genetic neurodegeneration. |
