Keyword search (4,163 papers available)

"Li P" Authored Publications:

Title Authors PubMed ID
1 Associations between brain and cognitive resilience, tau load and extent in Alzheimer's disease Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; Zheng Y; Aumont E; Wang YT; Arias JF; Real APB; Jia WL; Hopewell R; Hsiao C; Soucy JP; Vitali P; Pascoal TA; Rosa-Neto P; 41512332
PERFORM
2 Alzheimer s Imaging Consortium Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; Zheng Y; Aumont E; Wang YT; Arias JF; Real APB; Jia WL; Hopewell R; Hsiao C; Soucy JP; Vitali P; Pascoal TA; Rosa-Neto P; 41433447
PERFORM
3 Trends in missed paediatric preventive primary care visits during the COVID-19 pandemic using routinely collected electronic medical records in Ontario, Canada (2015-2022) Bayoumi I; Mcfadden K; Valkanas H; Tu K; Kalia S; Chen T; Christie CD; Rourke J; Rourke L; Greiver M; Leduc D; Li P; 41290264
CONCORDIA
4 Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol Bherer L; Vrinceanu T; Dupuy EG; Gayda M; Vincent T; Magnan PO; Mohammadi H; Gauthier C; Gagnon C; Duchesne S; Erickson KI; Gagnon D; Lesage F; Lupien S; Poirier J; Dubé MP; Thorin É; Juneau M; Breton J; Belleville S; Ferland G; Gaudreau-Majeau F; Blanchette CA; Vitali P; Nigam A; 40625372
PSYCHOLOGY
5 Adaptive finite-time synchronized control of multi-robotic fiber placement system with model uncertainties and disturbances Zhang R; Wang Y; Xie W; Li P; Tan H; Jiang Y; 40461302
ENCS
6 Dynamic and Reprocessable Fluorinated Poly(hindered urea) Network Materials Containing Ionic Liquids to Enhance Triboelectric Performance Nellepalli P; Kim MP; Park J; Noh SM; Ye Z; Jung HW; Ko H; Oh JK; 35385641
CHEMBIOCHEM
7 Dynamic Covalent Polyurethane Network Materials: Synthesis and Self-healability Nellepalli P; Patel T; Oh JK; 34418209
CHEMBIOCHEM
8 Macromolecularly Engineered Thermoreversible Heterogeneous Self-Healable Networks Encapsulating Reactive Multidentate Block Copolymer-Stabilized Carbon Nanotubes Zhang G; Patel T; Nellepalli P; Bhagat S; Hase H; Jazani AM; Salzmann I; Ye Z; Oh JK; 33988899
CHEMBIOCHEM
9 Self-Healable Reprocessable Triboelectric Nanogenerators Fabricated with Vitrimeric Poly(hindered Urea) Networks. Patel T, Kim MP, Park J, Lee TH, Nellepalli P, Noh SM, Jung HW, Ko H, Oh JK 32840992
CHEMBIOCHEM
10 Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children. Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, Hiremath S, Feldman RD, Tobe SW, Campbell TS, Bacon SL, Nerenberg KA, Dresser GK, Fournier A, Burgess E, Lindsay P, Rabkin SW, Prebtani APH, Grover S, Honos G, Alfonsi JE, Arcand J, Audibert F, Benoit G, Bittman J, Bolli P, Côté AM, Dionne J, Don-Wauchope A, Edwards C, Firoz T, Gabor JY, Gilbert RE, Grégoire JC, Gryn SE, Gupta M, Hannah-Shmouni F, Hegele RA, Herman RJ, H 32389335
HKAP
11 Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension. Leung AA, Nerenberg K, Daskalopoulou SS, McBrien K, Zarnke KB, Dasgupta K, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Tobe SW, Ruzicka M, Burns KD, Vallée M, Prasad GV, Lebel M, Feldman RD, Selby P, Pipe A, Schiffrin EL, McFarlane PA, Oh P, Hegele RA, Khara M, Wilson TW, Penner SB, Burgess E, Herman RJ, Bacon SL, Rabkin SW, Gilbert RE, Campbell TS, Grover S, Honos G, Lindsay P, Hill MD, Coutts SB, Gubitz G, Campbell NR, Moe GW, Howlett JG, Boulanger JM, Prebtani A, Laroc 27118291
HKAP
12 Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults. Leung AA, Daskalopoulou SS, Dasgupta K, McBrien K, Butalia S, Zarnke KB, Nerenberg K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Tran KC, Tobe SW, Ruzicka M, Burns KD, Vallée M, Prasad GVR, Gryn SE, Feldman RD, Selby P, Pipe A, Schiffrin EL, McFarlane PA, Oh P, Hegele RA, Khara M, Wilson TW, Penner SB, Burgess E, Sivapalan P, Herman RJ, Bacon SL, Rabkin SW, Gilbert RE, Campbell TS, Grover S, Honos G, Lindsay P, Hill MD, Coutts SB, Gubitz G, Campbell 28449828
HKAP
13 Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children. Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Padwal RS, Tran KC, Grover S, Rabkin SW, Moe GW, Howlett JG, Lindsay P, Hill MD, Sharma M, Field T, Wein TH, Shoamanesh A, Dresser GK, Hamet P, Herman RJ, Burgess E, Gryn SE, Grégoire JC, Lewanczuk R, Poirier L, Campbell TS, Feldman RD, Lavoie KL, Tsuyuki RT, Honos G, Prebtani APH, Kline G, Schiffrin EL, Don-Wauchope A, Tobe SW, Gilbert RE, 29731013
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Title:Associations between brain and cognitive resilience, tau load and extent in Alzheimer's disease
Authors:Mitchell SW,  Chan T,  Trudel L,  Hosseini SA,  Macedo AC,  Gonçalves MP,  Rahmouni N,  Hall BJ,  Socualaya KMQ,  Therriault J,  Servaes S,  Bezgin G,  Zheng Y,  Aumont E,  Wang YT,  Arias JF,  Real APB,  Jia WL,  Hopewell R,  Hsiao C,  Soucy JP,  Vitali P,  Pascoal TA,  Rosa-Neto P
Link:pubmed.ncbi.nlm.nih.gov/41512332/
DOI:10.1002/alz70856_107705
Publication:Alzheimer s & dementia : the journal of the Alzheimer s Association
Keywords:
PMID:41512332 Category: Date Added:2026-01-09
Dept Affiliation: PERFORM
1 Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montréal, QC, Canada.2 McGill University, Montreal, QC, Canada.3 Montreal Neurological Institute, Montreal, QC, Canada.4 McGill University Research Centre for Studies in Aging, Montreal, QC, Canada.5 The McGill University Research Centre for Studies in Aging, Montreal, QC, Canada.6 Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, QC, Canada.7 Translational Neuroimaging Laboratory, Montréal, QC, Canada.8 6630 Sherbrooke West, app. 1605, Montréal, QC, H4B 1N7, Montréal, QC, Canada.9 McGill University, Montréal, QC, Canada.10 LR12SP11 Sahloul University Hospital, Sousse, Tunisia.11 Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.12 McGill Centre for Studies in Aging, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.13 Montreal Neurological Institute, Montréal, QC, Canada.14 Université du Québec à Montréal, Montréal, QC, Canada.15 Translational Neuroimaging Laboratory / Montreal Neurological Institute, Montreal, QC, Canada.16 Jenny de Andrade Faria Institute - Reference Center for the Elderly, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil, Belo Horizonte, Minas Gerais, Brazil.17 Sciences Applied to Adult Health Postgraduate Program, Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.18 Department of Geriatrics, McGill University, Montreal, QC, Canada.19 Hospital das Clínicas da UFMG, University Hospital, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.20 USP, São Paulo, São Paulo, Brazil.21 Cog-Aging Research Group, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.22 Jewish General Hospital, Montreal, QC, Canada.23 McGill University Centre for Studies in Aging, Montreal, QC, Canada.24 Division of Geriatric Medicine, McGill University, Montreal, QC, Canada.25 Goldman Herzl Family Practice Centre, Montreal, QC, Canada.26 Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.27 Department of Family Medicine, McGill University, Montreal, QC, Canada.28 Douglas Mental Health University Institute, Montreal, QC, Canada.29 PERFORM Centre - Concordia University, Montréal, QC, Canada.30 PERFORM Centre, Concordia University, Montreal, QC, Canada.31 Université de Montréal, Montréal, QC, Canada.32 Montreal Neurological Institute, McGill University, Montréal, QC, Canada.33 University of Montreal hospital centre, Montreal, QC, Canada.34 McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.35 Montreal Neurological Institute, McGill University, Montreal, QC, Canada.36 Translational Neuroimaging, Montréal, QC, Canada.37 Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada.38 CIUSSS du Nord-de-l'Île-de-Montréal, Montreal, QC, Canada.39 University of Pittsburgh, Pittsburgh, PA, USA.40 Translational Neuroimaging Lab, Verdun, QC, Canada.41 McGill University Research Centre for Studies in Aging, Verdun, QC, Canada.42 Department of Psychiatry and Neurology, Pittsburgh, PA, USA.43 Douglas Hospital Research Centre, Verdun, QC, Canada.44 University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.45 Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.46 Centre for Studies on Prevention of Alzheimer's Disease (StoP-AD Centr

Description:

Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer's disease (AD). Tau pathology can be characterized in terms of spatial extent of tauopathy (SEOT) or load using standardized uptake value ratio (SUVR). The aim was to compare SEOT and SUVR in their association with BR and CR. To replicate findings from Ossenkoppele et al. (2020) using MK-6240 PET imaging and evaluate demographic, genetic, and imaging factors associated with BR and CR. The objective of this study is to assess the value of SEOT metrics in resilience models and compare their predictive power to standardized uptake value ratio (SUVR) and to evaluate cross sectional interactions between tau pathology, cognitive resilience, and cognitive decline.

Method: We assessed 126 amyloid-ß-positive participants TRIAD cohort with tau-PET using [<sup>18</sup>F]MK6240 and cognitive assessments (MMSE). SEOT was quantified as the proportion of voxels considered as abnormal relative to young controls. We used Participants recruited from TRIAD cohort, including individuals with mild cognitive impairment (MCI) or AD, positive amyloid-ß biomarkers, MK-6240 PET imaging data.

Result: Higher Whole Cortex MK SUVR is associated with lower MMSE scores, showing increased tau pathology correlates with cognitive decline. MCI patients maintain higher MMSE scores despite some tau accumulation, while AD patients show greater variability and decline. The negative trend suggests tau deposition contributes to cognitive impairment, but other factors may also play a role. 2. Whole Cortex MK SUVR vs. MMSE the negative correlation between Whole Cortex SEOT and MMSE appears stronger, with a more pronounced decline in cognitive function (MMSE scores) as SEOT increases, suggesting SEOT may be a more sensitive marker of disease progression in AD patients.

Conclusion: Whole Cortex SEOT exhibits a stronger negative correlation with MMSE compared to Whole Cortex MK-6240 SUVR, indicating that SEOT may serve as a more sensitive marker of cognitive decline in Alzheimer's disease and mild cognitive impairment. Further research is needed to validate SEOT's potential as a diagnostic or prognostic biomarker in neurodegenerative conditions.




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