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PubMed Publications| Keyword search (4,164 papers available) |  |
"Lavinia A Carabet" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Mechanism of the Nitric Oxide Dioxygenase Reaction of Mycobacterium tuberculosis Hemoglobin N | Lavinia A Carabet | 28835102 CERMM |
| Title: | Mechanism of the Nitric Oxide Dioxygenase Reaction of Mycobacterium tuberculosis Hemoglobin N | ||||
| Authors: | Lavinia A Carabet | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/28835102/ | ||||
| DOI: | 10.1021/acs.jpcb.7b06494 | ||||
| Publication: | The journal of physical chemistry. B | ||||
| Keywords: | |||||
| PMID: | 28835102 | Category: | J Phys Chem B | Date Added: | 2019-05-31 |
| Dept Affiliation: |
CERMM
1 Department of Chemistry and Biochemistry and Centre for Research in Molecular Modeling (CERMM), Concordia University , Montréal, Québec, Canada H4B 1R6. |
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Description: |
Many globins convert ^(•)NO to innocuous NO(3)^(-) through their nitric oxide dioxygenase (NOD) activity. Mycobacterium tuberculosis fights the oxidative and nitrosative stress imposed by its host (the toxic effects of O(2)^(•-) and ^(•)NO species and their OONO^(-) and ^(•)NO(2) derivatives) through the action of truncated hemoglobin N (trHbN), which catalyzes the NOD reaction with one of the highest rates among globins. The general NOD mechanism comprises the following steps: binding of O(2)... |
