Keyword search (4,163 papers available)

"Lafferty CK" Authored Publications:

Title Authors PubMed ID
1 All-optical approaches to studying psychiatric disease Lafferty CK; Christinck TD; Britt JP; 34314828
CSBN
2 Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior. Lafferty CK, Britt JP 32269514
CSBN
3 Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking. Lafferty CK, Yang AK, Mendoza JA, Britt JP 32187545
CSBN
4 Cannabis Exposure Enhances Subcortical Control of Nucleus Accumbens Activity. Lafferty CK; Britt JP; 32164914
CSBN
5 Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability. Yang AK, Mendoza JA, Lafferty CK, Lacroix F, Britt JP 31699294
CSBN
6 Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value. Mendoza JA, Lafferty CK, Yang AK, Britt JP 31693885
CSBN
7 Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption. Reed SJ, Lafferty CK, Mendoza JA, Yang AK, Davidson TJ, Grosenick L, Deisseroth K, Britt JP 30146308
PSYCHOLOGY

 

Title:Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior.
Authors:Lafferty CK,  Britt JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/32269514?dopt=Abstract
DOI:10.3389/fncir.2020.00010
Publication:Frontiers in neural circuits
Keywords:ArchT;  nucleus accumbens;  optogenetics;  photoinhibition;  reward-seeking; 
PMID:32269514 Category:Front Neural Circuits Date Added:2020-04-10
Dept Affiliation: CSBN
1 Department of Psychology, McGill University, Montreal, QC, Canada.
2 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.

Description:

Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior.

Front Neural Circuits. 2020;14:10

Authors: Lafferty CK, Britt JP

Abstract

Archaerhodopsin (ArchT)-mediated photoinhibition of axon terminals is commonly used to test the involvement of specific long-range neural projections in behavior. Although sustained activation of this opsin in axon terminals has the unintended consequence of enhancing spontaneous vesicle release, it is unclear whether this desynchronized signaling is consequential for ArchT's behavioral effects. Here, we compare axon terminal and cell body photoinhibition of nucleus accumbens (NAc) afferents to test the utility of these approaches for uncovering pathway-specific contributions of neural circuits to behavior. First, in brain slice recordings we confirmed that ArchT photoinhibition of glutamatergic axons reduces evoked synaptic currents and increases spontaneous transmitter release. A further consequence was increased interneuron activity, which served to broadly suppress glutamate input via presynaptic GABAB receptors. In vivo, axon terminal photoinhibition increased feeding and reward-seeking behavior irrespective of the afferent pathway targeted. These behavioral effects are comparable to those obtained with broad inhibition of NAc neurons. In contrast, cell body inhibition of excitatory NAc afferents revealed a pathway-specific contribution of thalamic input to feeding behavior and amygdala input to reward-seeking under extinction conditions. These findings underscore the off-target behavioral consequences of ArchT-mediated axon terminal inhibition while highlighting cell body inhibition as a valuable alternative for pathway-specific optogenetic silencing.

PMID: 32269514 [PubMed - in process]




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