Keyword search (4,163 papers available)

"Krishnan A" Authored Publications:

Title Authors PubMed ID
1 Different behavioral measures of conditioned magazine activity can tell different stories about brain function Volz S; Loewinger G; Marquez I; Fevola S; Kang M; Reverte I; Krishnan A; Gardner MPH; Iordanova MD; Esber GR; 41922165
CSBN
2 G protein-coupled estrogen receptor-1 enhances excitatory synaptic responses in the entorhinal cortex Batallán Burrowes AA; Sundarakrishnan A; Bouhour C; Chapman CA; 34399010
PSYCHOLOGY
3 Overestimation of Postpartum Depression Prevalence Based on a 5-item Version of the EPDS: Systematic Review and Individual Participant Data Meta-analysis Thombs BD; Levis B; Lyubenova A; Neupane D; Negeri Z; Wu Y; Sun Y; He C; Krishnan A; Vigod SN; Bhandari PM; Imran M; Rice DB; Azar M; Chiovitti MJ; Saadat N; Riehm KE; Boruff JT; Cuijpers P; Gilbody S; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Barnes J; Beck CT; Bindt C; Figueiredo B; Helle N; Howard LM; Kohlhoff J; Kozinszky Z; Leonardou AA; Radoš SN; Quispel C; Rochat TJ; Stein A; Stewart RC; Tadinac M; Tandon SD; Tendais I; Töreki A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Benedetti A; 33104415
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4 Depression prevalence based on the Edinburgh Postnatal Depression Scale compared to Structured Clinical Interview for DSM DIsorders classification: Systematic review and individual participant data meta-analysis Lyubenova A; Neupane D; Levis B; Wu Y; Sun Y; He C; Krishnan A; Bhandari PM; Negeri Z; Imran M; Rice DB; Azar M; Chiovitti MJ; Saadat N; Riehm KE; Boruff JT; Ioannidis JPA; Cuijpers P; Gilbody S; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Vigod SN; Aceti F; Barnes J; Bavle AD; Beck CT; Bindt C; Boyce PM; Bunevicius A; Chaudron LH; Favez N; Figueiredo B; Garcia-Esteve L; Giardinelli L; Helle N; Howard LM; Kohlhoff J; Kusminskas L; Kozinszky Z; Lelli L; Leonardou AA; Meuti V; Radoš SN; García PN; Pawlby SJ; Quispel C; Robertson-Blackmore E; Rochat TJ; Sharp DJ; Siu BWM; Stein A; Stewart RC; Tadinac M; Tandon SD; Tendais I; Töreki A; Torres-Giménez A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Benedetti A; Thombs BD; 33089942
CONCORDIA
5 Protocol for a partially nested randomised controlled trial to evaluate the effectiveness of the scleroderma patient-centered intervention network COVID-19 home-isolation activities together (SPIN-CHAT) program to reduce anxiety among at-risk scleroderma patients. Thombs BD, Kwakkenbos L, Carrier ME, Bourgeault A, Tao L, Harb S, Gagarine M, Rice D, Bustamante L, Ellis K, Duchek D, Wu Y, Bhandari PM, Neupane D, Carboni-Jiménez A, Henry RS, Krishnan A, Sun Y, Levis B, He C, Turner KA, Benedetti A, Culos-Reed N, El-Baalbaki G, Hebblethwaite S, Bartlett SJ, Dyas L, Patten S, Varga J, Scleroderma Patient-centered Intervention Network (SPIN) COVID-19 Patient Advisory Team, SPIN Investigators 32521358
PSYCHOLOGY
6 Patient Health Questionnaire-9 scores do not accurately estimate depression prevalence: individual participant data meta-analysis Levis B; Benedetti A; Ioannidis JPA; Sun Y; Negeri Z; He C; Wu Y; Krishnan A; Bhandari PM; Neupane D; Imran M; Rice DB; Riehm KE; Saadat N; Azar M; Boruff J; Cuijpers P; Gilbody S; Kloda LA; McMillan D; Patten SB; Shrier I; Ziegelstein RC; Alamri SH; Amtmann D; Ayalon L; Baradaran HR; Beraldi A; Bernstein CN; Bhana A; Bombardier CH; Carter G; Chagas MH; Chibanda D; Clover K; Conwell Y; Diez-Quevedo C; Fann JR; Fischer FH; Gholizadeh L; Gibson LJ; Green EP; Greeno CG; Hall BJ; Haroz EE; Ismail K; Jetté N; Khamseh ME; Kwan Y; Lara MA; Liu SI; Loureiro SR; Löwe B; Marrie RA; Marsh L; McGuire A; Muramatsu K; Navarrete L; Osório FL; Petersen I; Picardi A; Pugh SL; Quinn TJ; Rooney AG; Shinn EH; Sidebottom A; Spangenberg L; Tan PLL; Taylor-Rowan M; Turner A; van Weert HC; Vöhringer PA; Wagner LI; White J; Winkley K; Thombs BD; 32105798
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7 Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale - Depression subscale scores: An individual participant data meta-analysis of 73 primary studies Wu Y; Levis B; Sun Y; Krishnan A; He C; Riehm KE; Rice DB; Azar M; Yan XW; Neupane D; Bhandari PM; Imran M; Chiovitti MJ; Saadat N; Boruff JT; Cuijpers P; Gilbody S; McMillan D; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Henry M; Ismail Z; Loiselle CG; Mitchell ND; Tonelli M; Al-Adawi S; Beraldi A; Braeken APBM; Büel-Drabe N; Bunevicius A; Carter G; Chen CK; Cheung G; Clover K; Conroy RM; Cukor D; da Rocha E Silva CE; Dabscheck E; Daray FM; Douven E; Downing MG; Feinstein A; Ferentinos PP; Fischer FH; Flint AJ; Fujimori M; Gallagher P; Gandy M; Goebel S; Grassi L; Härter M; Jenewein J; Jetté N; Julião M; Kim JM; Kim SW; Kjærgaard M; Köhler S; Loosman WL; Löwe B; Martin-Santos R; Massardo L; Matsuoka Y; Mehnert A; Michopoulos I; Misery L; Navines R; O' Donnell ML; Öztürk A; Peceliuniene J; Pintor L; Ponsford JL; Quinn TJ; Reme SE; Reuter K; Rooney AG; Sánchez-González R; Schwarzbold ML; Senturk Cankorur V; Shaaban J; Sharpe L; Sharpe M; Simard S; Singer S; Stafford L; Stone J; Sultan S; Teixeira AL; Tiringer I; Turner A; Walker J; Walterfang M; Wang LJ; White J; Wong DK; Benedetti A; Thombs BD; 31911325
LIBRARY
8 Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta-analysis Levis B; McMillan D; Sun Y; He C; Rice DB; Krishnan A; Wu Y; Azar M; Sanchez TA; Chiovitti MJ; Bhandari PM; Neupane D; Saadat N; Riehm KE; Imran M; Boruff JT; Cuijpers P; Gilbody S; Ioannidis JPA; Kloda LA; Patten SB; Shrier I; Ziegelstein RC; Comeau L; Mitchell ND; Tonelli M; Vigod SN; Aceti F; Alvarado R; Alvarado-Esquivel C; Bakare MO; Barnes J; Beck CT; Bindt C; Boyce PM; Bunevicius A; Couto TCE; Chaudron LH; Correa H; de Figueiredo FP; Eapen V; Fernandes M; Figueiredo B; Fisher JRW; Garcia-Esteve L; Giardinelli L; Helle N; Howard LM; Khalifa DS; Kohlhoff J; Kusminskas L; Kozinszky Z; Lelli L; Leonardou AA; Lewis BA; Maes M; Meuti V; Nakic Radoš S; Navarro García P; Nishi D; Okitundu Luwa E-Andjafono D; Robertson-Blackmore E; Rochat TJ; Rowe HJ; Siu BWM; Skalkidou A; Stein A; Stewart RC; Su KP; Sundström-Poromaa I; Tadinac M; Tandon SD; Tendais I; Thiagayson P; Töreki A; Torres-Giménez A; Tran TD; Trevillion K; Turner K; Vega-Dienstmaier JM; Wynter K; Yonkers KA; Benedetti A; Thombs BD; 31568624
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Title:Different behavioral measures of conditioned magazine activity can tell different stories about brain function
Authors:Volz SLoewinger GMarquez IFevola SKang MReverte IKrishnan AGardner MPHIordanova MDEsber GR
Link:https://pubmed.ncbi.nlm.nih.gov/41922165/
DOI:10.1523/ENEURO.0560-24.2026
Publication:eNeuro
Keywords:
PMID:41922165 Category: Date Added:2026-04-02
Dept Affiliation: CSBN
1 Brooklyn College, City University of New York, Department of Psychology, 2900 Bedford Ave, Brooklyn, NY, 11210.
2 Machine Learning Team, National Institute of Mental Health, NIH, Bethesda, MD.
3 Department of Medical and Life Sciences & Department of Psychology, La Ciénaga University Center, University of Guadalajara, Ocotlán, Mexico.
4 The Graduate Center, City University of New York, 365 5th Ave, New York, NY, 10016.
5 Sapienza University of Rome, Dept. of Physiology and Pharmacology, Piazzale Aldo Moro 5, 00185, Roma, Italia.
6 Concordia University, Department of Psychology, CSBN/GRNC, 7141 Sherbrooke St., W. Montreal H4B 1R6.

Description:

Elucidating the neural substrates of Pavlovian reward learning requires reliable behavioral readouts. In conditioned magazine approach studies, rodents express reward expectancy by approaching the food magazine during cues that predict reward. This behavior is typically quantified using one of three measures: number of head entries, percentage of time in the magazine, or latency to respond. Yet these measures often diverge within the same discrimination task, making reliance on a single metric problematic. At the individual level, some animals express discrimination learning most clearly in one measure while showing little or no learning in the others, and animals may even switch their preferred measure across training. Reporting only one measure therefore risks underestimating the ability of a subset of animals. At the group level, sampling error can produce apparent differences across replications of the same design, limiting replicability. Moreover, brain manipulations can alter response topography, such that choosing one measure over another may lead to conflicting interpretations of neural function. To address this issue, we recommend reporting all raw behavioral measures and supplementing them with a dimensionality-reduction approach such as principal component analysis (PCA). Across multiple discrimination tasks in rats from both sexes, we show that subject-specific first principal component (PC1) scores provide a composite index that more consistently reflects discrimination learning than any single raw measure. This approach enhances statistical power, improves reproducibility, and helps distinguish true learning deficits from changes in response topography. However, its broader application will require continued validation and careful consideration of its inherent methodological trade-offs.Significance Statement Accurately characterizing Pavlovian reward learning requires reliable measurement of individual behavioral responses. In conditioned magazine approach studies, behavior is typically quantified by a single measure-such as head entries, time at the magazine, or response latency-but these measures often diverge. Reliance on one metric can underestimate discrimination ability, compromise reproducibility, and distort interpretations of neural manipulations. We show that applying principal component analysis (PCA) to integrate multiple response measures yields a robust discrimination index that better reflects individual performance. This approach increases effect sizes, strengthens replicability, and reduces misinterpretation, providing scientific, economic, and ethical benefits for research on cue-reward learning.





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