PERFORM Publications

Keyword search (4,164 papers available)

Title		Authors	PubMed ID
1	EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy	Afnan J; Cai Z; Lina JM; Abdallah C; Delaire E; Avigdor T; Ros V; Hedrich T; von Ellenrieder N; Kobayashi E; Frauscher B; Gotman J; Grova C;	38994740 SOH
2	Clinical Yield of Electromagnetic Source Imaging and Hemodynamic Responses in Epilepsy: Validation With Intracerebral Data	Abdallah C; Hedrich T; Koupparis A; Afnan J; Hall JA; Gotman J; Dubeau F; von Ellenrieder N; Frauscher B; Kobayashi E; Grova C;	35473762 PERFORM
3	How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism	Pellegrino G; Hedrich T; Sziklas V; Lina JM; Grova C; Kobayashi E;	34002916 PERFORM
4	Deconvolution of hemodynamic responses along the cortical surface using personalized functional near infrared spectroscopy	Machado A; Cai Z; Vincent T; Pellegrino G; Lina JM; Kobayashi E; Grova C;	33727581 PERFORM
5	Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.	DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E	33401137 PERFORM
6	Effects of Independent Component Analysis on Magnetoencephalography Source Localization in Pre-surgical Frontal Lobe Epilepsy Patients	Pellegrino G, Xu M, Alkuwaiti A, Porras-Bettancourt M, Abbas G, Lina JM, Grova C, Kobayashi E,	32582009 PERFORM
7	Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.	Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E	32386115 PERFORM
8	Magnetoencephalography resting state connectivity patterns as indicatives of surgical outcome in epilepsy patients.	Aydin Ü, Pellegrino G, Bin Ka'b Ali O, Abdallah C, Dubeau F, Lina JM, Kobayashi E, Grova C	32191632 PERFORM
9	Inferior Longitudinal Fasciculus' Role in Visual Processing and Language Comprehension: A Combined MEG-DTI Study.	Shin J, Rowley J, Chowdhury R, Jolicoeur P, Klein D, Grova C, Rosa-Neto P, Kobayashi E	31507359 PERFORM
10	Localization Accuracy of Distributed Inverse Solutions for Electric and Magnetic Source Imaging of Interictal Epileptic Discharges in Patients with Focal Epilepsy.	Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E	25609211 PERFORM
11	MEG-EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy.	Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C	26016950 PERFORM
12	Detection and Magnetic Source Imaging of Fast Oscillations (40-160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients.	von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E	26830767 PERFORM
13	Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy.	Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E	26931511 PERFORM
14	Source localization of the seizure onset zone from ictal EEG/MEG data.	Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C	27059157 PERFORM
15	Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.	Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C	29024165 PERFORM
16	Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.	Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C	29164737 PERFORM
17	Optimal positioning of optodes on the scalp for personalized functional near-infrared spectroscopy investigations.	Machado A, Cai Z, Pellegrino G, Marcotte O, Vincent T, Lina JM, Kobayashi E, Grova C	30107210 PERFORM
18	Complex patterns of spatially extended generators of epileptic activity: Comparison of source localization methods cMEM and 4-ExSo-MUSIC on high resolution EEG and MEG data.	Chowdhury RA, Merlet I, Birot G, Kobayashi E, Nica A, Biraben A, Wendling F, Lina JM, Albera L, Grova C	27561712 PERFORM
19	Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging.	DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E	27578494 PERFORM
20	Comparison of the spatial resolution of source imaging techniques in high-density EEG and MEG.	Hedrich T, Pellegrino G, Kobayashi E, Lina JM, Grova C	28619655 PERFORM

Title:	Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.
Authors:	DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E
Link:	https://www.ncbi.nlm.nih.gov/pubmed/33401137
DOI:	10.1016/j.nicl.2020.102552
Publication:	NeuroImage. Clinical
Keywords:	Epilepsy; FCD; Network; PET; mGluR5;
PMID:	33401137	Category:	Neuroimage Clin	Date Added:	2021-01-06
Dept Affiliation:	PERFORM 1 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada. Electronic address: jonathan.dubois@biogen.com. 2 Translational Neuroimaging Laboratory, McGill Center for Studies in Aging, Douglas Mental Health University Institute, McGill University, Montreal, Canada. 3 Division of Nuclear Medicine and Molecular Imaging, Johns Hopkins University, Baltimore, United States. 4 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada. 5 Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States. 6 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada; Department of Pathology, McGill University, Montreal, Canada. 7 PET Unit, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada; Bio-Imaging Group, PERFORM Centre, Concordia University, Montreal, Canada. 8 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada; Translational Neuroimaging Laboratory, McGill Center for Studies in Aging, Douglas Mental Health University Institute, McGill University, Montreal, Canada; PET Unit, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada. 9 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada. Electronic address: eliane.kobayashi@mcgill.ca.

Description:

Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.

Neuroimage Clin. 2020 Dec 29; 29:102552

Authors: DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E

Abstract

To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [11C]ABP688 PET binding potentials (BPND), which allows for quantification of mGluR5 availability. Undirected graphs were constructed for the entire cortex in 17 FCD patients and 33 healthy controls using inter-regional similarity of [11C]ABP688 BPND. We assessed group differences in network integration between healthy controls and the ipsilateral and contralateral hemispheres of FCD patients. Compared to healthy controls, FCD patients showed reduced network efficiency and reduced small-world connectivity. The mGluR5 network of FCD patients was also less resilient to targeted removal of high centrality nodes, suggesting a less integrated network organization. In highly efficient hub nodes of FCD patients, we observed a significant negative correlation between local efficiency and duration of epilepsy only in the contralateral hemisphere, suggesting that some nodes may be more vulnerable to persistent epileptic activity. Our study provides the first in vivo evidence for a widespread reduction in cortical mGluR5 network integration in FCD patients. In addition, we find that ongoing epileptic activity may alter chemoarchitectural brain organization resulting in reduced efficiency in distant regions that are essential for network integration.

PMID: 33401137 [PubMed - as supplied by publisher]

BookR: School of Health Core Facilities Booking

"Kobayashi E" Authored Publications:

Search Publications

No results