PERFORM Publications

Keyword search (4,163 papers available)

Title		Authors	PubMed ID
1	Web-based processing of physiological noise in fMRI: addition of the PhysIO toolbox to CBRAIN	Valevicius D; Beck N; Kasper L; Boroday S; Bayer J; Rioux P; Caron B; Adalat R; Evans AC; Khalili-Mahani N;	37841811 ENCS
2	The association between information and communication technologies, loneliness and social connectedness: A scoping review	Petersen B; Khalili-Mahani N; Murphy C; Sawchuk K; Phillips N; Li KZH; Hebblethwaite S;	37034933 PSYCHOLOGY
3	Double-Bind of Recruitment of Older Adults Into Studies of Successful Aging via Assistive Information and Communication Technologies: Mapping Review	Khalili-Mahani N; Sawchuk K;	36563033 CONCORDIA
4	Toward a digital citizen lab for capturing data about alternative ways of self-managing chronic pain: An attitudinal user study	Khalili-Mahani N; Woods S; Holowka EM; Pahayahay A; Roy M;	36188996 PERFORM
5	A Simulation Toolkit for Testing the Sensitivity and Accuracy of Corticometry Pipelines	OmidYeganeh M; Khalili-Mahani N; Bermudez P; Ross A; Lepage C; Vincent RD; Jeon S; Lewis LB; Das S; Zijdenbos AP; Rioux P; Adalat R; Van Eede MC; Evans AC;	34381348 PERFORM
6	What Media Helps, What Media Hurts: A Mixed Methods Survey Study of Coping with COVID-19 Using the Media Repertoire Framework and the Appraisal Theory of Stress	Pahayahay A; Khalili-Mahani N;	32701459 PERFORM
7	Reflective and Reflexive Stress Responses of Older Adults to Three Gaming Experiences In Relation to Their Cognitive Abilities: Mixed Methods Crossover Study.	Khalili-Mahani N, Assadi A, Li K, Mirgholami M, Rivard ME, Benali H, Sawchuk K, De Schutter B	32213474 PERFORM
8	Cyberinfrastructure for Open Science at the Montreal Neurological Institute.	Das S, Glatard T, Rogers C, Saigle J, Paiva S, MacIntyre L, Safi-Harab M, Rousseau ME, Stirling J, Khalili-Mahani N, MacFarlane D, Kostopoulos P, Rioux P, Madjar C, Lecours-Boucher X, Vanamala S, Adalat R, Mohaddes Z, Fonov VS, Milot S, Leppert I, Degroot C, Durcan TM, Campbell T, Moreau J, Dagher A, Collins DL, Karamchandani J, Bar-Or A, Fon EA, Hoge R, Baillet S, Rouleau G, Evans AC	28111547 IMAGING
9	Affective Game Planning for Health Applications: Quantitative Extension of Gerontoludic Design Based on the Appraisal Theory of Stress and Coping.	Khalili-Mahani N, De Schutter B	31172966 PERFORM
10	Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.	Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM	28145075 PERFORM
11	To Each Stress Its Own Screen: A Cross-Sectional Survey of the Patterns of Stress and Various Screen Uses in Relation to Self-Admitted Screen Addiction	Khalili-Mahani N; Smyrnova A; Kakinami L;	30938685 PERFORM

Title:	Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.
Authors:	Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28145075?dopt=Abstract
DOI:	10.1002/hbm.23516
Publication:	Human brain mapping
Keywords:	PK/PD modeling; arterial spin labeling; biomarkers; brain chemistry; drug; functional connectivity; pharma-fMRI; pharmacological neuroimaging; resting state fMRI; translational research;
PMID:	28145075	Category:	Hum Brain Mapp	Date Added:	2019-04-15
Dept Affiliation:	PERFORM 1 McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Canada. 2 PERFORM Centre, Concordia University, Montreal, Canada. 3 Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands. 4 Institute of Psychology and Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands. 5 Oxford Centre for Functional MRI of the Brain, Oxford University, Oxford, United Kingdom. 6 Biospective Inc, Montreal, Quebec, Canada. 7 McLean Hospital, Belmont, Massachusetts. 8 Harvard Medical School, Boston, Massachusetts. 9 Center for Pain and the Brain, Harvard Medical School & Boston Children's Hospital, Boston, Massachusetts. 10 Department of Anesthesiology, Leiden University Medical Centre, Leiden, The Netherlands. 11 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada. 12 Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom. 13 Centre for Human Drug Research, Leiden University Medical Centre, Leiden, The Netherlands.

Description:

Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.

Hum Brain Mapp. 2017 04;38(4):2276-2325

Authors: Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM

Abstract

A decade of research and development in resting-state functional MRI (RSfMRI) has opened new translational and clinical research frontiers. This review aims to bridge between technical and clinical researchers who seek reliable neuroimaging biomarkers for studying drug interactions with the brain. About 85 pharma-RSfMRI studies using BOLD signal (75% of all) or arterial spin labeling (ASL) were surveyed to investigate the acute effects of psychoactive drugs. Experimental designs and objectives include drug fingerprinting dose-response evaluation, biomarker validation and calibration, and translational studies. Common biomarkers in these studies include functional connectivity, graph metrics, cerebral blood flow and the amplitude and spectrum of BOLD fluctuations. Overall, RSfMRI-derived biomarkers seem to be sensitive to spatiotemporal dynamics of drug interactions with the brain. However, drugs cause both central and peripheral effects, thus exacerbate difficulties related to biological confounds, structured noise from motion and physiological confounds, as well as modeling and inference testing. Currently, these issues are not well explored, and heterogeneities in experimental design, data acquisition and preprocessing make comparative or meta-analysis of existing reports impossible. A unifying collaborative framework for data-sharing and data-mining is thus necessary for investigating the commonalities and differences in biomarker sensitivity and specificity, and establishing guidelines. Multimodal datasets including sham-placebo or active control sessions and repeated measurements of various psychometric, physiological, metabolic and neuroimaging phenotypes are essential for pharmacokinetic/pharmacodynamic modeling and interpretation of the findings. We provide a list of basic minimum and advanced options that can be considered in design and analyses of future pharma-RSfMRI studies. Hum Brain Mapp 38:2276-2325, 2017. © 2017 Wiley Periodicals, Inc.

PMID: 28145075 [PubMed - indexed for MEDLINE]

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