Keyword search (4,163 papers available)

"Jazani AM" Authored Publications:

Title Authors PubMed ID
1 Design, Synthesis, and Acid-Responsive Disassembly of Shell-Sheddable Block Copolymer Labeled with Benzaldehyde Acetal Junction Andrade-Gagnon B; Casillas-Popova SN; Jazani AM; Oh JK; 38499007
CHEMBIOCHEM
2 Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide Choi M; Jazani AM; Oh JK; Noh SM; 35683912
CHEMBIOCHEM
3 Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK; 34050688
CHEMBIOCHEM
4 Macromolecularly Engineered Thermoreversible Heterogeneous Self-Healable Networks Encapsulating Reactive Multidentate Block Copolymer-Stabilized Carbon Nanotubes Zhang G; Patel T; Nellepalli P; Bhagat S; Hase H; Jazani AM; Salzmann I; Ye Z; Oh JK; 33988899
CHEMBIOCHEM
5 Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery. Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG 33455300
CHEMBIOCHEM
6 Facile Strategies to Synthesize Dual Location Dual Acidic pH/Reduction-Responsive Degradable Block Copolymers Bearing Acetal/Disulfide Block Junctions and Disulfide Pendants. Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK 31459031
CHEMBIOCHEM
7 PLA-Based Triblock Copolymer Micelles Exhibiting Dual Acidic pH/Reduction Responses at Dual Core and Core/Corona Interface Locations. Bawa KK, Jazani AM, Shetty C, Oh JK 30286258
CHEMBIOCHEM

 

Title:Facile Strategies to Synthesize Dual Location Dual Acidic pH/Reduction-Responsive Degradable Block Copolymers Bearing Acetal/Disulfide Block Junctions and Disulfide Pendants.
Authors:Jazani AM,  Arezi N,  Maruya-Li K,  Jung S,  Oh JK
Link:https://www.ncbi.nlm.nih.gov/pubmed/31459031?dopt=Abstract
DOI:10.1021/acsomega.8b01310
Publication:ACS omega
Keywords:
PMID:31459031 Category:ACS Omega Date Added:2019-08-29
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke St. W., Montreal, Quebec, Canada H4B 1R6.

Description:

Facile Strategies to Synthesize Dual Location Dual Acidic pH/Reduction-Responsive Degradable Block Copolymers Bearing Acetal/Disulfide Block Junctions and Disulfide Pendants.

ACS Omega. 2018 Aug 31;3(8):8980-8991

Authors: Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK

Abstract

We report new dual acidic pH/reduction-responsive degradable amphiphilic block copolymers featured with dual acidic pH-labile acetal linkage and a reductively-cleavable disulfide bond at the hydrophilic/hydrophobic block junction as well as pendant disulfide bonds in the hydrophobic block. Centered on the use of a macroinitiator approach, three strategies utilize the combination of atom transfer radical polymerization and reversible addition fragmentation chain transfer polymerization in a sequential or concurrent mechanism, along with facile coupling reactions. Combined structural analysis with dual-stimuli-responsive degradation investigation allows better understanding of the architectures and orthogonalities of the formed block copolymers as a diblock or a triblock copolymer. Our study presents the development of effective synthetic strategies to well-defined multifunctional amphiphilic block copolymers that exhibit dual-stimuli-responsive degradation at dual location (called the DL-DSRD strategy), thus potentially promising as nanoassemblies for effective drug delivery.

PMID: 31459031 [PubMed]




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