Keyword search (4,164 papers available)

"Jaworska N" Authored Publications:

Title Authors PubMed ID
1 A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M; 39725679
CSBN
2 Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion D' Amour-Horvat V; Cox SML; Dagher A; Kolivakis T; Jaworska N; Leyton M; 34463411
CSBN
3 mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use. Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M 32413893
CSBN
4 Extra-striatal D2/3 receptor availability in youth at risk for addiction. Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M 32259831
CSBN
5 Pre-treatment EEG signal variability is associated with treatment success in depression. Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB 29159049
CSBN
6 Effect of GAD1 genotype status on auditory attention and acute nicotine administration in healthy volunteers. Hadjis E, Hyde M, Choueiry J, Jaworska N, Nelson R, de la Salle S, Smith D, Aidelbaum R, Knott V 30488987
CSBN
7 Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans. Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M 30607444
CSBN
8 Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors. Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M 30627817
CSBN

 

Title:Pre-treatment EEG signal variability is associated with treatment success in depression.
Authors:Jaworska N,  Wang H,  Smith DM,  Blier P,  Knott V,  Protzner AB
Link:https://www.ncbi.nlm.nih.gov/pubmed/29159049?dopt=Abstract
Publication:
Keywords:
PMID:29159049 Category:Neuroimage Clin Date Added:2019-05-31
Dept Affiliation: CSBN
1 Institute of Mental Health Research, Affiliated With the University of Ottawa, ON, Canada.
2 Department of Psychology, University of Calgary, AB, Canada.
3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
4 Department of Psychology, University of Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, AB, Canada. Electronic address: protzner@ucalgary.ca.

Description:

Pre-treatment EEG signal variability is associated with treatment success in depression.

Neuroimage Clin. 2018;17:368-377

Authors: Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB

Abstract

Background: Previous work suggests that major depressive disorder (MDD) is associated with disturbances in global connectivity among brain regions, as well as local connectivity within regions. However, the relative importance of these global versus local changes for successful antidepressant treatment is unknown. We used multiscale entropy (MSE), a measure of brain signal variability, to examine how the propensity for local (fine scale MSE) versus global (coarse scale MSE) neural processing measured prior to antidepressant treatment is related to subsequent treatment response.

Methods: We collected resting-state EEG activity during eyes-open and closed conditions from unmedicated individuals with MDD prior to antidepressant pharmacotherapy (N = 36) as well as from non-depressed controls (N = 36). Treatment response was assessed after 12 weeks of treatment using the Montgomery-Åsberg Depression Rating Scale (MADRS), at which time participants with MDD were characterized as either responders (= 50% MADRS decrease) or non-responders. MSE was calculated from baseline EEG, and compared between controls, future treatment responders and non-responders. Putative interactions with the well-documented age effect on signal variability (increased reliance on local neural communication with increasing age, indexed by greater finer-scale variability) were assessed.

Results: Only in responders, we found that reduced MSE at fine temporal scales (especially fronto-centrally) and increased MSE diffusely at coarser temporal scales was related to the magnitude of the antidepressant response. In controls and MDD non-responders, but not MDD responders, there was an increase in MSE with age at fine temporal scales and a decrease in MSE with age at coarse temporal scales.

Conclusion: Our results suggest that an increased propensity toward global processing, indexed by greater MSE at coarser timescales, at baseline appears to facilitate eventual antidepressant treatment response.

PMID: 29159049 [PubMed - indexed for MEDLINE]




BookR developed by Sriram Narayanan
for the Concordia University School of Health
Copyright © 2011-2026
Cookie settings
Concordia University