PERFORM Publications

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Title		Authors	PubMed ID
1	An active bifunctional natural dye for stable all-solid-state organic batteries	Yu Q; Hu Y; Deng S; Shakouri M; Chen J; Martins V; Nie HY; Huang Y; Zhao Y; Zaghib K; Sham TK; Li X;	40993135 PHYSICS
2	Comparison of photocatalysis and photolysis of 2,2,4,4-tetrabromodiphenyl ether (BDE-47): Operational parameters, kinetic studies, and data validation using three modern machine learning models	Motamedi M; Yerushalmi L; Haghighat F; Chen Z; Zhuang Y;	36907486 ENCS
3	Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.	Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG	33455300 CHEMBIOCHEM
4	Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.	Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG	31820915 CHEMBIOCHEM
5	Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length.	Huang Y, Yim OS, Lai PS, Yu R, Chew SH, Gwee X, Nyunt MSZ, Gao Q, Ng TP, Ebstein RP, Gouin JP	30708136 PSYCHOLOGY

Title:	Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.
Authors:	Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG
Link:	https://www.ncbi.nlm.nih.gov/pubmed/31820915
DOI:	10.1021/acsami.9b17101
Publication:	ACS applied materials & interfaces
Keywords:	directed self-assembly; drug delivery; microfluidics; nanoparticles; stimuli-responsive block copolymers;
PMID:	31820915	Category:	ACS Appl Mater Interfaces	Date Added:	2020-09-24
Dept Affiliation:	CHEMBIOCHEM 1 Department of Chemistry , University of Victoria , PO Box 1700 Stn CSC, Victoria , BC V8W 2Y2 Canada. 2 Department of Chemistry and Biochemistry , Concordia University , 7141 Sherbrooke St. West , Montreal , Quebec H4B 1R6 , Canada.

Description:

Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.

ACS Appl Mater Interfaces. 2020 Jan 08; 12(1):177-190

Authors: Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG

Abstract

Microfluidic flow-directed self-assembly of biological stimuli-responsive block copolymers is demonstrated with dual-location cleavable linkages at the junction between hydrophilic and hydrophobic blocks and on pendant group within the hydrophobic blocks. On-chip self-assembly within a two-phase microfluidic reactor forms various "DualM" polymer nanoparticles (PNPs), including cylinders and multicompartment vesicles, with sizes and morphologies that are tunable with manufacturing flow rate. Complex kinetically trapped intermediates between shear-dependent states provide the most detailed mechanism to date of microfluidic PNP formation in the presence of flow-variable high shear. Glutathione (GSH)-triggered changes in PNP size and internal structure depend strongly on the initial flow-directed size and internal structure. Upon incubation in GSH, flow-directed PNPs with smaller average sizes showed a faster hydrodynamic size increase (attributed to junction cleavage) and those with higher excess Gibbs free energy showed faster inner compartment growth (attributed to pendant cleavage). These results demonstrate that the combination of chemical control of the location of biologically responsive linkages with microfluidic shear processing offers promising routes for tunable "smart" polymeric nanomedicines.

PMID: 31820915 [PubMed - indexed for MEDLINE]

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