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PubMed Publications| Keyword search (4,163 papers available) |  |
"Hernandez R RA" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions | Hernandez R RA; Burchell-Reyes K; Braga APCA; Lopez JK; Forgione P; | 35424611 CHEMBIOCHEM |
| Title: | Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions | ||||
| Authors: | Hernandez R RA, Burchell-Reyes K, Braga APCA, Lopez JK, Forgione P | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/35424611/ | ||||
| DOI: | 10.1039/d1ra08443g | ||||
| Publication: | RSC advances | ||||
| Keywords: | |||||
| PMID: | 35424611 | Category: | Date Added: | 2022-04-15 | |
| Dept Affiliation: |
CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University 7141 rue Sherbrooke O. Montréal QC Canada H4B 1R6 pat.forgione@concordia.ca. 2 Centre for Green Chemistry and Catalysis, McGill University 801 rue Sherbrooke O. Montréal QC Canada H3A 0B8. |
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Description: |
Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a recyclable Cu/Al2O3 nanocomposite catalyst. Furthermore, the proposed conditions are reproducible to a 1.0-gram scale without further milling time variations. |
