Keyword search (4,163 papers available)

"Dakik P" Authored Publications:

Title Authors PubMed ID
1 Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast. Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard É, Titorenko VI 32577164
BIOLOGY
2 Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast. Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakhsh S, Maalaoui H, Simard É, Titorenko VI 31645900
BIOLOGY
3 Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae. Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI 28930594
BIOLOGY
4 Some Metabolites Act as Second Messengers in Yeast Chronological Aging. Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI 29543708
BIOLOGY
5 Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die. Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI 29636840
BIOLOGY
6 Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay. Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI 30719227
BIOLOGY
7 Quiescence Entry, Maintenance, and Exit in Adult Stem Cells. Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI 31052375
BIOLOGY
8 Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla. Dakik P, Medkour Y, Mohammad K, Titorenko VI 31057428
BIOLOGY

 

Title:Some Metabolites Act as Second Messengers in Yeast Chronological Aging.
Authors:Mohammad K,  Dakik P,  Medkour Y,  McAuley M,  Mitrofanova D,  Titorenko VI
Link:https://www.ncbi.nlm.nih.gov/pubmed/29543708?dopt=Abstract
DOI:10.3390/ijms19030860
Publication:International journal of molecular sciences
Keywords:cell signaling;  chronological aging;  interorganellar communications;  mechanisms of longevity regulation;  metabolism;  mitochondria;  proteostasis;  regulated cell death;  second messengers;  yeast; 
PMID:29543708 Category:Int J Mol Sci Date Added:2019-06-07
Dept Affiliation: BIOLOGY
1 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. karamat.mohammad@concordia.ca.
2 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. pameladakik@gmail.com.
3 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. writetoyounes@gmail.com.
4 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. melissa.mcauley@concordia.ca.
5 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. mitrofanova_darya@hotmail.com.
6 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. vladimir.titorenko@concordia.ca.

Description:

Some Metabolites Act as Second Messengers in Yeast Chronological Aging.

Int J Mol Sci. 2018 Mar 15;19(3):

Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Abstract

The concentrations of some key metabolic intermediates play essential roles in regulating the longevity of the chronologically aging yeast Saccharomyces cerevisiae. These key metabolites are detected by certain ligand-specific protein sensors that respond to concentration changes of the key metabolites by altering the efficiencies of longevity-defining cellular processes. The concentrations of the key metabolites that affect yeast chronological aging are controlled spatially and temporally. Here, we analyze mechanisms through which the spatiotemporal dynamics of changes in the concentrations of the key metabolites influence yeast chronological lifespan. Our analysis indicates that a distinct set of metabolites can act as second messengers that define the pace of yeast chronological aging. Molecules that can operate both as intermediates of yeast metabolism and as second messengers of yeast chronological aging include reduced nicotinamide adenine dinucleotide phosphate (NADPH), glycerol, trehalose, hydrogen peroxide, amino acids, sphingolipids, spermidine, hydrogen sulfide, acetic acid, ethanol, free fatty acids, and diacylglycerol. We discuss several properties that these second messengers of yeast chronological aging have in common with second messengers of signal transduction. We outline how these second messengers of yeast chronological aging elicit changes in cell functionality and viability in response to changes in the nutrient, energy, stress, and proliferation status of the cell.

PMID: 29543708 [PubMed - indexed for MEDLINE]




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